Hepatitis B surface antigen and antibody positivity among women of childbearing age after three decades of universal vaccination in South Korea

Hur, Yun Jung; Choe, Sug–Bong; Choe, Young June; Paek, Jinyoung

doi:10.1016/j.ijid.2020.11.147

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…In highly endemic countries, transmission is mainly perinatal, from a carrier mother to her newborn. 23 Hur et al 24 illustrated that the HBsAg positivity was 3.5% (n = 5050) and the anti-HB positivity was 75.3% (n = 109,907) among 145,993 women of childbearing age (20–49) during 2001–2018 in South Korea. The national prevalence of new, chronic HB diagnoses among women of childbearing age in US decreased significantly from .83% in 2011 to .19% in 2017.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of chronic HB among Korean American women of childbearing age in Queens, NY, was estimated to be .49% (3 out of 604) during the period of our study. We assumed that our estimate of .49% was in between .19% 25 and 3.5% 24 because some proportion of childbearing aged Korean American women were born in US and some immigrated from South Korea. This assumption needs to be elucidated in future study.…”

Section: Discussionmentioning

confidence: 99%

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Age-specific seroprotection after Hepatitis B virus vaccination among Korean American pediatric population in Queens, New York

Min

Kim

2022

Human Vaccines & Immunotherapeutics

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Hepatitis B Virus (HBV) infection is a major health issue among Asian Americans. The prevalence of chronic Hepatitis B infection in New York City is estimated to be 2.7% compared with .3% in the overall United States. The efficacy and long-term immunity of HBV vaccination in the Korean American pediatric population in Queens, NY, are not well explored. This study aimed to 1) determine the age-specific prevalence of anti-HBs seropositivity in the Korean American pediatric population and 2) assess biologic/demographic factors influencing immunologic response to HBV vaccine. We performed a retrospective chart review of patients registered to a pediatric health clinic located in Queens, NY, from October 2014 to October 2020. Out of 604 medical records of patients aged ≤18 years who received a completed series of HBV vaccines during infancy, we analyzed 91 medical records where HBV serology test (HBsAg and anti-HBs) results were available. Three out of 91 subjects were born to HBsAg-positive mothers. Eight out of 91 subjects were born in South Korea. Overall, 54.9% of subjects were anti-HBs-seropositive. The seropositive rate in the 15 to 18-years-old-age group (14.3%) was significantly lower than that in other age groups: < 1 year (100%) (p = .015), 1–4 years (52.6%) (p = .033), 5–9 years (63.3%) (p = .0034), and 10–14 years (64%) (p = .0063). The mean duration since vaccination in seropositive subjects was 96.5 ± 53.9 months, and that in seronegative subjects was 121.7 ± 64.2 months (p < .047). Gender, BMI, and foreign birth were not significant risk factors affecting the nonseroprotective status. The role of routine screening of anti-HB titers and booster vaccination in this endemic community needs to be further explored.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Age-specific seroprotection after Hepatitis B virus vaccination among Korean American pediatric population in Queens, New York

Min

Kim

2022

Human Vaccines & Immunotherapeutics

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“…In 2019, South Korea (Republic of Korea) achieved HepB3 coverage of 98%, and HepB-birth dose coverage of 92% [6]. In South Korea (Republic of Korea), the prevalence of HBsAg in child-bearing-aged females (20-49 years) is 1.7-3.7% in recent years [65,66]. In pregnant females, the HBsAg prevalence is 3.32% in 2012 [67].…”

Section: Central Asia (Afghanistan Kazakhstan Kyrgyzstan Tajikistan T...mentioning

confidence: 99%

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

et al. 2022

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Hepatitis B virus (HBV) infection still remains a major public health issue in the Asia-Pacific region. Most of the burden of HBV-related disease results from infections acquired in infancy through perinatal or early childhood exposure to HBV in Asia-Pacific. Hepatitis B during pregnancy presents unique management issues for both the mother and fetus. These APASL guidelines provide a comprehensive review and recommendations based on available evidence in the literature, for the management of females with HBV infection through every stage of pregnancy and postpartum. These also address the concerns, management challenges, and required follow-up of children born to hepatitis B-positive mothers.

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“…By conventional de nitions, this result alone does not indicate the development of clinically signi cant active hepatitis but can be considered an alarming indicator that warrants monitoring for the development of active hepatitis. In the context of immunosuppression following HSCT, viral reactivation in pre-existing infections is a common setting in patients with HBsAg-RS, and the risk factors for this are well understood [5][6][7]. However, there seems to be a lack of consensus on the management of the broader spectrum of situations that can lead to HBsAg-RS, including de novo infections and other causes [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Surface Antigen Reverse Seroconversion after Hematopoietic Stem Cell Transplantation According to Baseline Serological Markers and Vaccination Status: A Single-Center Database Analysis

Kang,

Ko,

Lee

et al. 2024

Preprint

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Purpose Hepatitis B is a major prognostic factor after hematopoietic stem cell transplantation (HSCT). Currently, there is a lack of consensus on the management of the broader spectrum of situations that can lead to reverse seroconversion of hepatitis B surface antigen (HBsAg-RS). Here, we focused on HBsAg-RS, a warning sign of active hepatitis development, and sought to obtain exploratory information on patient and treatment factors associated with it. Methods We conducted a single-center retrospective study using clinical data extracted from the electronic medical records of Seoul St. Mary’s Hospital, Korea. Patients who underwent HSCT between January 2013 and December 2018 and were hepatitis B surface antigen (HBsAg)-negative before HSCT were included. The associations of HBsAg-RS with demographic information, baseline hepatitis B serologic markers, and vaccination status were statistically analyzed. Results This study included 1,344 patients, of whom 83.3% tested positive for hepatitis B surface antibody (HBsAb) at the time of HSCT. HBsAg-RS occurred in 2.2% of HBsAb-negative patients and 3.0% of HBsAb-positive patients, indicating no significant difference in reactivation rates by HBsAb status. However, testing positive for the hepatitis B core antibody (HBcAb) was significantly associated with hepatitis B virus reactivation (HBsAg-RS rate, 8.0%). Vaccination rates were highest in patients who were negative for both HBsAb and HBcAb, and they had a transient protective effect. Conclusion The adequate patient population analyzed allowed us to identify an association between baseline HBcAb positivity and the development of HBsAg-RS. The need for prospective studies on appropriate vaccination methods to prevent HBsAg-RS is suggested.

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Hepatitis B surface antigen and antibody positivity among women of childbearing age after three decades of universal vaccination in South Korea

Cited by 4 publications

References 33 publications

Age-specific seroprotection after Hepatitis B virus vaccination among Korean American pediatric population in Queens, New York

Age-specific seroprotection after Hepatitis B virus vaccination among Korean American pediatric population in Queens, New York

Asian Pacific association for the study of liver (APASL) guidelines: hepatitis B virus in pregnancy

Hepatitis B Surface Antigen Reverse Seroconversion after Hematopoietic Stem Cell Transplantation According to Baseline Serological Markers and Vaccination Status: A Single-Center Database Analysis

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