Hepatitis B reactivation in an Irish dialysis unit, 2005

Thornton, Lelia; Fitzpatrick, Fidelma; D, De La Harpe; Brennan, Aline; Murphy, Niamh; Connell, Jeff; Humphreys, Hilary; Smyth, Elizabeth; Walshe, J. Joseph; Crean, Margaret

doi:10.2807/esm.12.04.00700-en

Cited by 5 publications

(5 citation statements)

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“…The majority of patients in the Irish cohort had unknown HBV vaccination status (62.7%), 13.4% were fully vaccinated, 4.6% partially vaccinated and 15.7% unvaccinated, and 76.6% had a titre <10 mIU/ml. 4 We found similar findings to these observations with large number of unvaccinated, non-immune, or patients with unknown immune status. This was due to the lack of a uniform policy of HBV vaccination and immunity testing in our unit.…”

Section: Case Reportsupporting

confidence: 88%

Hepatitis B virus reactivation in a large haemodialysis unit: Virological and infection control issues

Bhattacharya

Ijaz²,

Ratnaraja

et al. 2009

Journal of Clinical Virology

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Section: Case Reportsupporting

confidence: 88%

Hepatitis B virus reactivation in a large haemodialysis unit: Virological and infection control issues

Bhattacharya

Ijaz²,

Ratnaraja

et al. 2009

Journal of Clinical Virology

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“…1 In the absence of specific Irish dialysis guidelines at this time, most Irish units, including this center, followed UK guidelines; that is, HBV surface antigen (HBsAg) testing was performed prior to dialysis and then monthly, ideally, but at least every 3 months. 2 The majority of units did not test for HBV core antibody (anti-HBc).…”

Section: Problems In the Interpretation Of Serological Results Of Hepmentioning

confidence: 99%

Problems in the Interpretation of Serological Results of Hepatitis B Testing During an Incident of Hepatitis B Virus Reactivation in a Dialysis Unit

Fitzpatrick

Crean

Kaminski

et al. 2007

Infect Control Hosp Epidemiol

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“…7 Our unit was a hepatitis B-free unit when this event occurred. The incident highlighted that at the time there were a variety of strategies for HBV vaccination and testing in place and the tracking of the vaccination schedule was incomplete for many patients.…”

Section: Methodsmentioning

confidence: 99%

“…6 Following a case of reactivation of HBV infection in a patient undergoing hemodialysis in our institution, a program of HBV serological testing and a two-vaccine protocol of HBV vaccination was instituted for all those at potential risk. 7 Herein, we report on its outcome and the potential factors influencing seroconversion.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Study of Hepatitis B Vaccination – A Comparison of Responders versus Nonresponders

et al. 2011

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Herein we present one of the largest single-center reports of the response of hemodialysis patients to a two-vaccine hepatitis B virus vaccination protocol in a European dialysis population. A hepatitis B recombinant DNA vaccine, HBvaxPRO ® , was given at a dose of 40 μg intramuscularly using a four-dose schedule at 0, 1, 2, and 12 months. Responses were (1) a titer >100 mIU/mL = patient immune, (2) a titer level 10-99 mIU/mL = give a booster dose and recheck level 2 months later, and (3) 0 ≤ 10 mIU/mL = repeat vaccination course using a different vaccine, Engerix-B ® . We compared responder groups in terms of titer levels for each vaccine and variables including age, gender, serum albumin, parathyroid hormone (PTH), calcium, phosphate, hemoglobin, years on dialysis, and type of dialysis access. Of the 176 patients who received the first vaccine course, 71 patients achieved immunity, that is, 40% uptake for the first vaccine. Of the 105 who failed, 72 received the second vaccine with 46 responders, that is, 64% uptake for the second vaccine. Overall, 143 of the 176 patients who entered the vaccination program completed the protocol with 117 achieving immunity, representing an 82% success rate. The only variable overall to show significance in achieving seroconversion was serum albumin (p = 0.03). Using a two-vaccine protocol, hepatitis B vaccination response was high in our population of end-stage renal disease patients.

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Hepatitis B reactivation in an Irish dialysis unit, 2005

Cited by 5 publications

References 0 publications

Hepatitis B virus reactivation in a large haemodialysis unit: Virological and infection control issues

Hepatitis B virus reactivation in a large haemodialysis unit: Virological and infection control issues

Problems in the Interpretation of Serological Results of Hepatitis B Testing During an Incident of Hepatitis B Virus Reactivation in a Dialysis Unit

A Prospective Study of Hepatitis B Vaccination – A Comparison of Responders versus Nonresponders

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