Hepatitis B Maternal Screening, Infant Vaccination, and Infant Prophylaxis Practices in North Carolina

Pierce, Richard L.; Smith, Sheree; Rowe-West, Beth; Sterritt, Barbara

doi:10.1001/archpedi.153.6.619

Cited by 17 publications

(9 citation statements)

References 17 publications

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“…In the study by Yusuf et al, 13 9 of 12 exposed infants were vaccinated and 8 of 12 received HBIG (timing unspecified). In the study by Pierce et al, 10 7 of 9 were vaccinated within 24 hours (HBIG administration not reported). Administration of HepB to infants who were born to women with unknown HBsAg status was higher in this study than in that reported by Yusuf et al (22%).…”

Section: Discussionmentioning

confidence: 96%

“…Infants who were born to women with inconsistencies in documented HBsAg status were less likely to receive prophylaxis, which has been reported previously. 10 The strongest predictor of newborn HepB receipt was having a written hospital policy for HepB administration at birth, highlighting the importance of such policies. Newborn HepB coverage was higher in this study (69%) than that reported in the 2007 National Immunization Survey (NIS) where 53.2% of newborns were vaccinated by the third day of life.…”

Section: Discussionmentioning

confidence: 99%

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Gaps in Hospital Policies and Practices to Prevent Perinatal Transmission of Hepatitis B Virus

Willis

Wortley²,

Wang

et al. 2010

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT:In the United States, an estimated 1.4 million people have chronic HBV infection, causing 2000 to 4000 deaths annually. Newborn HepB administration is a key intervention to prevent perinatal HBV transmission and morbidity and mortality caused by chronic HBV infection. WHAT THIS STUDY ADDS:This study examined how well national recommendations for perinatal HBV prevention advocated by the CDC and the ACIP are implemented by hospitals. It also reveals considerable gaps in hospital policies and practices that need to be addressed. abstract OBJECTIVE: The objective of this study was to examine hospital policies and practices to prevent perinatal transmission of hepatitis B virus (HBV) in the United States and to and identify gaps. METHODS: In March 2006, a nationally representative sample of 242 delivery hospitals in the 50 states, District of Columbia, and Puerto Rico (with at least 100 annual births) were surveyed about hospital perinatal hepatitis B prevention policies and asked to review paired maternal-infant medical records for 25 consecutive live births. Main outcome measures were hospital policies related to the prevention of perinatal transmission of hepatitis B and the proportion of infants who received recommended care. RESULTS: A total of 190 of 242 hospitals responded to the survey and completed medical record reviews for 4762 mothers and 4786 infants. The proportion of hospitals that reported each of the 6 policies examined ranged from 63.0% to 80.6%. Among infants who were born to the 18 hepatitis B surface antigen (HBsAg)-positive women with documented prenatal test results, 62.1% received both hepatitis B vaccine and hepatitis B immunoglobulin within 12 hours, but 13.7% were unvaccinated and 19.7% did not receive hepatitis B immunoglobulin before hospital discharge. Among infants who were born to the 320 women with unknown HBsAg status, only 52.4% were vaccinated within 12 hours of birth and 20.1% were unvaccinated before discharge. Among infants who were born to HBsAg-negative mothers, 69.1% received the hepatitis B vaccine before hospital discharge. The strongest predictor of vaccine administration was having a written hospital policy for newborn hepatitis B vaccination. CONCLUSIONS: These findings indicate that significant gaps persist in hospital policies and practices to prevent perinatal HBV transmission in the United States. Efforts to avoid medical errors through appropriate implementation and monitoring of hospital practices are needed to eliminate perinatal HBV transmission.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Gaps in Hospital Policies and Practices to Prevent Perinatal Transmission of Hepatitis B Virus

Willis

Wortley²,

Wang

et al. 2010

Pediatrics

View full text Add to dashboard Cite

show abstract

“…The rate is, however, much higher than that reported from developed countries. A sero‐prevalence rate of 0.2% was reported among pregnant women in North Carolina, United States of America (13), whilst a sero‐prevalence of 1.6% was recently reported from the King Fahd Hospital, Saudi‐Arabia (14). The rate is also higher than those reported from recent studies in other parts of Nigeria.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for hepatitis B virus infection among pregnant women in Lagos, Nigeria

Rabiu

Akinola

Adewunmi

et al. 2010

Acta Obstet Gynecol Scand

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“…In Greece, the carrier rate in pregnant women varies between 2.8 and 3.0% [25]. In the US, the prevalence of HBs Ag among pregnant women [26][27][28] showed differences according to race or ethnicity: white (0.1-0.6%), African American (0.1-0.7%), Hispanic (0.4%), Asian (4.6-8.8%). The prevalences were comparable in Asian populations living in US and in France, but African women living in France have had higher HBs Ag prevalences than African American women (4.61-7.48%).…”

Section: Influence Of the Ethnic Originmentioning

confidence: 99%

Sreening of pregnant women for hepatitis B markers in a French Provincial University Hospital (Limoges) during 15 years

et al. 2004

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During the 15 years from January 1984 to December 1998 the Limoges University Hospital screened 22,859 pregnant patients for hepatitis B surface antigen (HBs Ag) and identified 149 positives. The overall prevalence (0.65%) was intermediate between prevalences observed among women of French origin (0.29%), French West Indies islands (5.68%) and of foreign origin particulary South East Asian origin (7.14%) and Sub Saharan African origin (6.52%). Hepatitis B Virus (HBV) replication markers was detected with relative low frequence (HBe Ag: 14.4%; HBV-DNA: 13.7-20%) among HBs Ag positive mothers. Markers of delta hepatitis virus was found among 10.5% of the HBs Ag carrier pregnant women. During the 15 years study period variations of the global prevalence were not statistically significant. Universal prenatal screening and infant immunisation could greatly contribute to the control of HBV infection if the polemic about the hepatitis B vaccination recently propagated in France will not have a negative effect on the acceptance and national programme of vaccination.

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Hepatitis B Maternal Screening, Infant Vaccination, and Infant Prophylaxis Practices in North Carolina

Cited by 17 publications

References 17 publications

Gaps in Hospital Policies and Practices to Prevent Perinatal Transmission of Hepatitis B Virus

Gaps in Hospital Policies and Practices to Prevent Perinatal Transmission of Hepatitis B Virus

Risk factors for hepatitis B virus infection among pregnant women in Lagos, Nigeria

Sreening of pregnant women for hepatitis B markers in a French Provincial University Hospital (Limoges) during 15 years

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