Abstract:BackgroundA study of the current situation and characteristics of hepatitis B virus (HBV) infection among Chinese pregnant women is meaningful to provide baseline information for future research and policy making, with an aim to eliminate HBV in China.ObjectivesTo provide the epidemiological status of HBV infection among pregnant women in China.MethodsPubMed, EMbase, The Cochrane Library, and three Chinese databases were searched. Cohort studies and cross-sectional studies on HBV prevalence in Chinese pregnant… Show more
“…There have been more reports of HBsAg seroprevalence in women than in men, driven by large serosurveys among pregnant women. Recently, a meta-analysis of 4 million women (compared with 121 million women included in our sex-specific analyses) across China estimated HBV seroprevalence at 7% in pregnant women during the period between 2016 and 2021, 30 which is somewhat higher than our estimate that decreased from about 5% to 4% during this period. Our estimate for female HBsAg prevalence during this period was influenced by a single large report of 90 million pregnant women, that reported a persistent decrease in HBsAg seroprevalence (7.3% to 5.4%) between 2015 and 2020.…”
ObjectiveChina concentrates a large part of the global burden of HBV infection, playing a pivotal role in achieving the WHO 2030 global hepatitis elimination target.MethodsWe searched for studies reporting HBV surface antigen (HBsAg) seroprevalence in five databases until January 2023. Eligible data were pooled using a generalised linear mixed model with random effects to obtain summary HBsAg seroprevalence. Linear regression was used to estimate annual percentage change (APC) and HBsAg prevalence in 2021.Results3740 studies, including 231 million subjects, were meta-analysed. HBsAg seroprevalence for the general population decreased from 9.6% (95% CI 8.4 to 10.9%) in 1973–1984 to 3.0% (95% CI 2.1 to 3.9%) in 2021 (APC=−3.77; p<0.0001). Decreases were more pronounced in children <5 years (APC=−7.72; p<0.0001) and 5–18 years (−7.58; p<0.0001), than in people aged 19–59 years (−2.44; p<0.0001), whereas HBsAg seroprevalence increased in persons ≥60 years (2.84; p=0.0007). Significant decreases were observed in all six major Chinese regions, in both men (APC=−3.90; p<0.0001) and women (−1.82; p<0.0001) and in high-risk populations. An estimated 43.3 million (95% uncertainty interval 30.7–55.9) persons remained infected with HBV in China in 2021 (3.0%), with notable heterogeneity by region (<1.5% in North China to>6% in Taiwan and Hong Kong) and age (0.3%, 1.0%, 4.7% and 5.6% for <5 years, 5–18 years, 19–59 years and≥60 years, respectively).ConclusionsChina has experienced remarkable decreases in HBV infection over the last four decades, but variations in HBsAg prevalence persist in subpopulations. Ongoing prevention of HBV transmission is needed to meet HBV elimination targets by 2030.Trial registration numberPROSPERO (CRD42021284217)
“…There have been more reports of HBsAg seroprevalence in women than in men, driven by large serosurveys among pregnant women. Recently, a meta-analysis of 4 million women (compared with 121 million women included in our sex-specific analyses) across China estimated HBV seroprevalence at 7% in pregnant women during the period between 2016 and 2021, 30 which is somewhat higher than our estimate that decreased from about 5% to 4% during this period. Our estimate for female HBsAg prevalence during this period was influenced by a single large report of 90 million pregnant women, that reported a persistent decrease in HBsAg seroprevalence (7.3% to 5.4%) between 2015 and 2020.…”
ObjectiveChina concentrates a large part of the global burden of HBV infection, playing a pivotal role in achieving the WHO 2030 global hepatitis elimination target.MethodsWe searched for studies reporting HBV surface antigen (HBsAg) seroprevalence in five databases until January 2023. Eligible data were pooled using a generalised linear mixed model with random effects to obtain summary HBsAg seroprevalence. Linear regression was used to estimate annual percentage change (APC) and HBsAg prevalence in 2021.Results3740 studies, including 231 million subjects, were meta-analysed. HBsAg seroprevalence for the general population decreased from 9.6% (95% CI 8.4 to 10.9%) in 1973–1984 to 3.0% (95% CI 2.1 to 3.9%) in 2021 (APC=−3.77; p<0.0001). Decreases were more pronounced in children <5 years (APC=−7.72; p<0.0001) and 5–18 years (−7.58; p<0.0001), than in people aged 19–59 years (−2.44; p<0.0001), whereas HBsAg seroprevalence increased in persons ≥60 years (2.84; p=0.0007). Significant decreases were observed in all six major Chinese regions, in both men (APC=−3.90; p<0.0001) and women (−1.82; p<0.0001) and in high-risk populations. An estimated 43.3 million (95% uncertainty interval 30.7–55.9) persons remained infected with HBV in China in 2021 (3.0%), with notable heterogeneity by region (<1.5% in North China to>6% in Taiwan and Hong Kong) and age (0.3%, 1.0%, 4.7% and 5.6% for <5 years, 5–18 years, 19–59 years and≥60 years, respectively).ConclusionsChina has experienced remarkable decreases in HBV infection over the last four decades, but variations in HBsAg prevalence persist in subpopulations. Ongoing prevention of HBV transmission is needed to meet HBV elimination targets by 2030.Trial registration numberPROSPERO (CRD42021284217)
“…When stressed, testicular tissue produces more ROS, which can stimulate the NF-B signaling pathway (nuclear factor kappa-light-chain-enhancer of activated B cells). The TNF-α expression can then be increased because of this pathway (Li et al, 2022;Zigam et al, 2023).…”
Background: Fertility in male animals is an important issue in veterinary medicine. Exposure to severe crowding and fattening may affect the fertility of these animals. Objectives: This study compares the effect of oxidative stress caused by overcrowding or obesity on testicular tissue in male albino mice. Methods: A total of 30 male mice were divided into 3 groups. The first was a control group. The second group was subjected to crowding by cramming 20 mice in a small cage. The third group was fattened by eating a high-fat diet. Morphometric cells and histological measurements of the seminiferous tubule diameter, epithelium thickness, and Sertoli and Leydig cell counts were taken. Results: The crowding group testes showed the presence of necrosis and degeneration of spermatocytes, Sertoli, and Leydig cells. The obese group’s spermatocytes, Sertoli, and Leydig cells had shown severe necrosis, degeneration, and giant cell invasion. Histomorphometric measurements of seminiferous tubule diameter, epithelium-thickness, and Sertoli and Leydig cell counts revealed a considerable reduction in the obese group compared to the other groups. Furthermore, in the crowding and fattening groups, measurements of oxidative stress indicators revealed a decrease in glutathione value in the obese group compared to the control, whereas malondialdehyde rose in the overcrowded and obese groups compared to the control. The results of the immunohistochemical expressions for tumor necrosis factor-α (TNF-α) in the testes of mice revealed weak TNF-α positive expression in the control group, moderate expression in the crowding group, and strong expression in the obesity group. Conclusion: The study suggests that both obesity and crowding can impair testicular function, with obesity having the most significant impact. More research into the mechanisms underlying these effects, as well as potential interventions to improve testicular function in obese or overcrowded animals, is required.
“…Speci cally, genotype B is predominant in Southern China, while genotype C prevails in Northern provinces [17,18]. The incidence of mother-to-child transmission in patients infected with HBV genotypes B and C is higher compared to other genotypes [19]. Genotype C is associated with early progression to liver cancer [20,21].…”
Background: Hepatitis B is one of the public health priorities worldwide, especially in the Southwest China. Our study aimed to investigate the relationship between genotypes and drug resistance mutations among HBV patients in Southwest China, with the objective of providing guidance for clinical antiviral treatment.
Methods: A total of 4266 chronic hepatitis B (CHB) patients treated in the Qianjiang Hospital of Chongqing University were included in our study from 2014 to 2020. Both genotypes and drug-resistant mutations of CHB patients were determined by polymerase chain reaction (PCR).
Results: Genotype B and genotype C were the main HBV genotypes in our study. We found 54 mutation patterns, including 9 single-site mutations and 45 multiple-site mutations, accounting for 57.64% and 42.36%, respectively. RT204 (485/1936) was the most common single-site mutation type, and RT180+RT204 (482/1936) was the most common multiple-site mutation type. 1372 CHB patients were resistant to LAM+LDT, and 342 CHB patients were resistant to ADV. There was only 1 CHB patient who exhibited resistance to LAM+LDT+ADV+ETV, with a specific mutation pattern of RT181+RT184+RT204.
Conclusion: Our study demonstrated trends in genetic mutations and drug resistance in CHB patients to enable timely adjustment of antiviral treatment strategies.
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