Hepatitis B immunity in adolescents and necessity for boost vaccination: 23 years after nationwide hepatitis B virus vaccination program in Taiwan

Lu, Ja-Yu; Cheng, Chi-Chia; Chou, Shieu-Ming; Hor, Chang-Bor; Yang, Yichen; Wang, Hsiang-Ling

doi:10.1016/j.vaccine.2009.08.007

Cited by 35 publications

(29 citation statements)

References 41 publications

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“…The younger the patient is, the longer the immunosuppression lasts [30]. Therefore, measles, mumps and VZV immunoglobulin may be relevant in young ALL patients who are suffering from severe neutropenia and lymphopenia at diagnosis to achieve short lived protection until being vaccinated at the end of treatment.…”

Section: Discussionmentioning

confidence: 99%

Measles, Mumps, Varicella Zoster, Diphtheria and Hepatitis B Surface Antibody Status in Pediatric Acute Leukemic Patients

El-Din¹,

Loutfy²,

Rahman³

2012

J Blood Disord Transfus

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Section: Discussionmentioning

confidence: 99%

Measles, Mumps, Varicella Zoster, Diphtheria and Hepatitis B Surface Antibody Status in Pediatric Acute Leukemic Patients

El-Din¹,

Loutfy²,

Rahman³

2012

J Blood Disord Transfus

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“…Thus, despite the loss of antibody many vaccinated individuals maintain active immune memory and show a strong anamnestic response following a booster dose of vaccine (the so-called boostability) given up to 20-25 y. [8][9][10][11][12] However other studies, mainly conducted in Asiatic countries, indicate that immune memory starts to wane during the second decade after vaccination still arising the question whether there is a need of a booster dose to maintain long-term immunity. 13,14 The aim of this study was to assess the duration of anti-HBs antibody and immune memory in a cohort of teenagers vaccinated as infants and in a cohort of young adults vaccinated as adolescents, 18-19 y earlier.…”

Section: Introductionmentioning

confidence: 99%

Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy

Romanò

Galli

Tagliacarne

et al. 2017

Human Vaccines & Immunotherapeutics

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This study was aimed at assessing the anti-HBs persistence and immune memory 18-19 y after vaccination against hepatitis B in healthy individuals primed as infants or adolescents. We enrolled 405 teenagers (Group A) vaccinated as infants, and 409 young adults (Group B) vaccinated as adolescents. All vaccinees were tested for anti-HBs and anti-HBc antibodies; those found anti-HBc positive were further tested for HBsAg and HBV DNA. Eight individuals belonging to Group B were positive for anti-HBc alone, and were excluded from analysis. Individuals with anti-HBs concentration 10 mIU/ml were considered protected while those with anti-HBs concentration <10 mIU/ml were offered a booster dose and re-tested 2 weeks later. Overall, 67.9% individuals showed anti-HBs concentrations 10 mIU/ml (48.9% in Group A vs 87.0% in Group B, p < 0.001). The antibody geometric mean concentration (GMC) was higher in Group B than in Group A (102.5 mIU/ml vs 6.9 mIU/ml; p < 0.001). When boosted, 94.2% of vaccinees with anti-HBs <10 mIU/ml belonging to Group A and 94.7% to Group B showed an anamnestic response. Post-booster GMCs were similar in both groups (477.9 mIU/ml for Group A vs 710.0 mIU/ml for Group B, p D n.s.). Strong immunological memory persists for at least 18-19 y after immunization of infants or adolescents with a primary course of vaccination. Thus, booster doses are not needed at this time, but additional follow up is required to assess the long-life longevity of protection.

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“…One report has revealed that students vaccinated at preschool age present higher anti-HBs positive rates than those vaccinated at birth, which implies that the production and persistence of anti-HBs may be dependent on the time of vaccination, such that the optimal vaccination time for HBV vaccine in children may be re-evaluated 24 . The HBsAg seroprevalence is still higher in adolescents than in children 25 , what implies that there were some individuals whose anti-HBs decreased from their childhood to adolescent period and became susceptible to HBV infection 24 . One report also revealed that the persistence of higher anti-HBs levels was associated with vaccination at older age 26 .…”

Section: Discussionmentioning

confidence: 99%

Anti-HBs levels among children and adolescents with complete immunization schedule against hepatitis B virus. A cross-sectional study in Blumenau, State of Santa Catarina, Brazil, 2007-2008

Livramento

Córdova

Scaraveli

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Vaccination is the main tool for preventing hepatitis B virus (HBV) infection; however, following the completion of the vaccination series, the concentrations of anti-HBs can decline over the years and reach levels less than 10mIU/mL. The persistence of protection in these individuals is still unknown. The present study aimed to determine the anti-HBs antibody levels among children and adolescents who had received a complete vaccination course for hepatitis B. Methods: Antibodies against HBV surface antigen (anti-HBs) were tested in 371 individuals aged 10 to 15 years-old. Results: Volunteers who showed undetectable quantities of anti-HBs accounted for 10.2% of the population studied and 39.9% presented antibody titers of less than 10mIU/mL. Anti-HBs ≥ 10mIU/mL were verified in 49.9%. Conclusions: These results corroborate other studies indicating levels of anti-HBs below 10mIU/mL in vaccinated individuals. Additional studies are required to assess whether this indicates susceptibility to HBV infection and the need and age for booster doses.

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Hepatitis B immunity in adolescents and necessity for boost vaccination: 23 years after nationwide hepatitis B virus vaccination program in Taiwan

Cited by 35 publications

References 41 publications

Measles, Mumps, Varicella Zoster, Diphtheria and Hepatitis B Surface Antibody Status in Pediatric Acute Leukemic Patients

Measles, Mumps, Varicella Zoster, Diphtheria and Hepatitis B Surface Antibody Status in Pediatric Acute Leukemic Patients

Persistence of immunity 18–19 years after vaccination against hepatitis B in 2 cohorts of vaccinees primed as infants or as adolescents in Italy

Anti-HBs levels among children and adolescents with complete immunization schedule against hepatitis B virus. A cross-sectional study in Blumenau, State of Santa Catarina, Brazil, 2007-2008

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