Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers

Kitab, Bouchra; Feydi, Abdellah Essaid El; Afifi, R.; Derdabi, Omar; Cherradi, Younes; Benazzouz, M.; Rebbani, Khadija; Brahim, Ikram; Alj, Hanane Salih; Zoulim, Fabien; Trépo, Christian; Chemin, Isabelle; Ezzikouri, Sayeh

doi:10.1016/j.jinf.2011.05.007

Cited by 45 publications

(60 citation statements)

References 46 publications

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“…This is consistent with others who reported predominance of D genotype in the studies performed in Arab countries that included females only [13][14][15][16][17][18][19][20][21].…”

Section: Disccussionsupporting

confidence: 92%

“…In Mosul, Iraq, Shafiq [12] [2013] reported that genotype D is the predominant genotype in HBV acute and chronic infections. In addition, another study found that D genotype is the predominant among Mosul blood donors [11].In Arab countries the predominant genotype was D in Saudi Arabia [13], United Arab Emirates [14], Yemen [15], Lebanon [16], Jordan [17], Egypt [25], Libya [18] Mauritania [19], Morocco [20], and Syria [21].…”

Section: Disccussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular and Immunological Study of Hepatitis B virus infection in Samara City, Iraq.

Abdulrazaq¹,

AL-Azaawie²

2017

Cihan Univ.-Erbil Sci. J.

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“…This is consistent with others who reported predominance of D genotype in the studies performed in Arab countries that included females only [13][14][15][16][17][18][19][20][21].…”

Section: Disccussionsupporting

confidence: 92%

Section: Disccussionmentioning

confidence: 99%

Molecular and Immunological Study of Hepatitis B virus infection in Samara City, Iraq.

Abdulrazaq¹,

AL-Azaawie²

2017

Cihan Univ.-Erbil Sci. J.

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show abstract

“…D is the most common genotype among the different settings throughout the previously mentioned Arab states [37][38][39][40][41][42][43][44][45][46].…”

Section: Genotypesmentioning

confidence: 99%

Hepatitis B and C virus infections among pregnant women in Arab and African countries

Gasim

Murad

Adam

2013

J Infect Dev Ctries

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Introduction: The epidemiology of viral hepatitis during pregnancy is of paramount importance for health planners and program managers. Data on viral hepatitis during pregnancy are not readily available in many African and Arab countries. Both regions have their own unique geography, and comprise over 59 states with crossover and interaction of different cultures. Methodology: A systematic electronic search of the published literature was conducted and data on epidemiology and risk factors of maternal hepatitis B virus (HBV) infection and hepatitis C (HCV) infection in Arab and African countries were extracted from relevant studies. Results: The serology of hepatitis viruses varies greatly among these countries, with different viral genotype patterns. Such a variation in prevalence could be explained by the different risk factors involved. Sexual contact, perinatal infection, blood and its derivatives, hemodialysis, intravenous and percutaneous drug use, and occupational, habitual, and social behavior have been identified as risk factors for hepatitis transmission in various settings in these countries. Conclusions: Infection from hepatitis B and C viruses imposes major socioeconomic and even political burdens on such young and dynamic societies. Thus strategies and clear policies of intervention are required to combat the consequences of hepatitis B and C at both the regional and national levels.

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“…Overall, 40 isolates belonged to subgenotypes D7 (40.4%) and 1 to subgenotype D2 (1%). Subgenotype D7 was recently described and found prevalent in Tunisia and in Morocco [16,20], suggesting to be the most predominant in the Maghreb. This hypothesis is reinforced by the results of our study.…”

Section: Discussionmentioning

confidence: 99%

Naturally Occurring Surface Antigen Variants of Hepatitis B Virus in Tunisian Patients

Chaouch¹,

Taffon²,

Villano³

et al. 2016

Intervirology

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In Tunisia, the prevalence of naturally occurring surface (S) gene variants of hepatitis B virus (HBV) has not been determined. In the present study, the prevalence of these variants was examined in terms of the clinical and viral state in a series of 99 Tunisian patients with HBV infection. The S genes were amplified and directly sequenced. Genotype D was predominant (98%), 40.4% isolates belonged to subgenotypes D7 and 1 to subgenotype D2. The most common subtype was ayw2 (95.9%). In total, 60.6% of the studied strains harbored S mutations. Several novel mutation patterns were detected. Interestingly, the presence of S mutations was significantly correlated with the D7 subgenotype, low HBV DNA and advancing age (≥35 years), and tended to be higher in liver cirrhosis than in chronic infection. The global prevalence of the major hydrophilic region variants was 12.1%, with substitution S143L/T as the most frequent (4%). Only 33.9% of S substitutions produced amino acid changes in the polymerase gene. In conclusion, a high prevalence of naturally occurring HBsAg variants was observed among Tunisian HBV carriers. Natural viral variability in a geographical region and duration of infection are among the major factors associated with the occurrence of S mutations.

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Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers

Cited by 45 publications

References 46 publications

Molecular and Immunological Study of Hepatitis B virus infection in Samara City, Iraq.

Molecular and Immunological Study of Hepatitis B virus infection in Samara City, Iraq.

Hepatitis B and C virus infections among pregnant women in Arab and African countries

Naturally Occurring Surface Antigen Variants of Hepatitis B Virus in Tunisian Patients

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