Hepatitis B e Antigen in Volunteer and Paid Blood Donors

Tabor, Edward; Goldfield, Martin; Black, Henry C.; Gerety, Robert J.

doi:10.1046/j.1537-2995.1980.20280169960.x

Cited by 16 publications

(3 citation statements)

References 26 publications

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“…'V2 The evolution to volunteer rather than paid donor programs has lessened the risk of hepatitis B. 3 With the advent of more efficient methods of iron chelation with deferoxamine, the incidence of iron overload has dirnini~hed.~-~ Sensitization to minor blood group antigens remains a significant problem. The proportion of patients sensitized to blood group antigens after at least one transfusion has been reported to range from 4 to 36 and is 33 percent in our center.…”

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confidence: 99%

Experience with donors matched for minor blood group antigens in patients with sickle cell anemia who are receiving chronic transfusion therapy

Ambruso¹,

Githens²,

et al. 1987

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Clinically significant alloimmunization to red cell antigens occurred in 28 percent of transfused patients in a sickle cell clinic. Therefore, a prospective study was undertaken to determine whether matching donors carefully for 17 blood group antigens would diminish the risk of further alloimmunization in patients on a chronic transfusion program. Alloantibodies had developed previously in 8 of the 12 patients. After chronic transfusion with selected donors, four new antibodies developed in three patients. Three antibodies were due to errors in phenotyping or matching, and one was due to an antigen that was not tested for in the protocol. The incidence of developing antibodies per unit transfused was diminished tenfold when selected donors were used. Autoantibodies developed in five patients (42%), but these did not seriously interfere with the transfusion therapy. It was concluded that matching for red cell antigens may diminish the incidence of alloimmunization in patients with sickle cell anemia requiring transfusion.

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confidence: 99%

Experience with donors matched for minor blood group antigens in patients with sickle cell anemia who are receiving chronic transfusion therapy

Ambruso¹,

Githens²,

et al. 1987

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“…Serum HBV markers are about 10 times more frequent in commercial than in volunteer blood donors [6,7]; this has been related to their low SEL. Our results show that an inverse relation between HBV and SEL also exists in healthy regular and volunteer blood donors born and living in an area of low HBV endemicity.…”

Section: Resultsmentioning

confidence: 99%

An Epidemiological and Clinical Study of Transaminase Levels and Hepatitis B Antibodies in 1,100 Blood Donors

Driss¹,

Boboc²,

Zarski³

et al. 1989

Vox Sanguinis

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In order to provide epidemiological and clinical information on surrogate testing of blood donations, the respective prevalences of serum hepatitis B virus (HBV) markers and elevated transaminase levels were studied in 1,100 blood donors according to their geographic origin and socioeconomic level. The frequency of serum HBV markers varied as a function of HBV endemicity in the country of origin; however, it was inversely correlated (p<0.05) to the socioeconomic level of the donors, even in those originating from countries of low HBV endemicity. There was no association between serum HBV markers and the increased transaminase level which was observed in 48 (4.3%) donors. Twenty-five of these accepted further clinical evaluation. A diagnosis appeared probable in 12 of the 25; alcohol in 5; drugs in 6; non-A, non-B hepatitis in 1. Seven of the remaining 13 subjects were more than 25% above ideal body weight. Transaminase activities determined at the time of clinical assessment were normal in 14. In addition, serum HBV DNA was found in 5 of 247 donors, even in the absence of any usual HBV marker and/or hypertransaminasemia. This could account for the few cases of B and B-like posttransfusion hepatitis which are known to still occur despite careful HBsAg screening of blood donors.

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“…One serum sample obtained from chimpanzee #16 at week 139 was also positive for both HBeAg and anti-HBe (data not shown). The simultaneous detection of HBeAg and anti-HBe has been reported using AGD 1261 and RIA [27] ;when detected by AGD these were shown to be HBeAg/l and anti-HBe/2 [26]. The clearance of HBeAg and the subsequent appearance of anti-HBe has been described in humans [28] and chimpanzees [27] with HBV infections.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis b e antigen and antibody: detection by radioimmunoassay in chimpanzees during experimental hepatitis b

Tabor¹,

Frösner²,

Deinhardt³

et al. 1980

Journal of Medical Virology

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Hepatitis B e antigen (HBeAg) and its antibody (anti-HBe) were evaluated using a sensitive radioimmunoassay (RIA) in weekly serum samples obtained from nine chimpanzees experimentally infected with hepatitis B virus (HBV). In two chimpanzees with HBV infection with detectable hepatitis B surface antigen (HBsAG) for less than five weeks, and in one chimpanzee with documented HBV infection with no detectable HBsAg, HBeAg was not detected; in all three, anti-HBe became detectable early in the infection. In six chimpanzees in which HGsAg was detected for 16 weeks or longer, HBeAg was detected early in the infection; in five, anti-HBe became detectable and HBeAg undetectable prior to the clearance of HBsAg. The sixth remained HGsAg-positive and HBeAg-positive for more than two years and never developed anti-HBe. These results confirmed the sensitivity of this RIA and its value in predicting the course of HBV infections.

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Hepatitis B e Antigen in Volunteer and Paid Blood Donors

Cited by 16 publications

References 26 publications

Experience with donors matched for minor blood group antigens in patients with sickle cell anemia who are receiving chronic transfusion therapy

Experience with donors matched for minor blood group antigens in patients with sickle cell anemia who are receiving chronic transfusion therapy

An Epidemiological and Clinical Study of Transaminase Levels and Hepatitis B Antibodies in 1,100 Blood Donors

Hepatitis b e antigen and antibody: detection by radioimmunoassay in chimpanzees during experimental hepatitis b

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