Hepatitis B, C and Delta virus infections in Albanian patients with chronic liver disease: evaluation of possible changes during the last 10 years

Kondili, Loreta A.; Cuko, Liri; Chionne, Paola; Candido, Angela; Madonna, Elisabetta; Dentico, P; Resuli, Bashkim; Taliani, Gloria; Brunetto, Maurizia Rossana; Rapicetta, Maria

doi:10.1097/meg.0b013e328330d410

Cited by 11 publications

(5 citation statements)

References 15 publications

(25 reference statements)

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“…In a previous study conducted on 18 patients with chronic liver diseases in Tirana using a line probe genotyping assay, HCV-1b was identified in 11 cases (61%), then HCV-2a/2c and HCV-3a were identified in five and two patients, respectively. 5 This distribution of HCV genotypes is similar to that observed here. In addition, the predominance of HCV-1b has been reported in other southeastern European countries, including Greece, Serbia, Montenegro, Slovenia, Croatia, and Bosnia and Herzegovina.…”

Section: Discussionsupporting

confidence: 88%

“…The prevalence of HCV antibodies was found to be 0.07% in blood donors, 2.3% and 0.3% in Albanian emigrant populations in Greece and southern Italy, respectively, and 14% and 11% in 1995 and 2005, respectively, for patients with viral and/or alcoholic liver disease at the University Hospital of Tirana, the capital city. [3][4][5] To our knowledge, HCV molecular epidemiology has been assessed only once in Albania, using a line probe genotyping assay. We determined HCV genotype prevalence in Albanian patients by sequencing.…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis C virus genotypes in Tirana, Albania

Haldeda

Baume

Tamalet

et al. 2014

International Journal of Infectious Diseases

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Hepatitis C virus (HCV) infection is a worldwide concern. Knowledge of the HCV genotype is clinically important because it predicts the rate of response to therapy and guides the treatment duration. Moreover, it allows molecular epidemiology to be performed. To our knowledge, the prevalence of HCV genotypes has been assessed only once in Albania, using a line probe genotyping assay. We determined HCV genotypes by population sequencing of HCV-infected patients in Tirana, Albania. HCV genotype and sequence analyses were performed for serum samples collected from January 2011 through May 2012 from 61 HCV-seropositive patients using population sequencing of the NS3 protease gene and alternatively the NS5b gene and the 5' untranslated region (UTR). HCV RNA was retrieved from the blood samples of 50 patients. The HCV NS3 protease gene was sequenced for 28 patients and NS5b and/or 5'UTR fragments were sequenced for an additional 22 patients. The predominant genotype was 1b in 25 patients (50%), followed by genotypes 2c, 4a, 3a, and 1a in 18%, 14%, 8%, and 6% of cases, respectively. Best matches for these HCV RNAs in GenBank were obtained in different countries worldwide. One NS3 protease naturally harbored an amino acid conferring minor drug resistance to newly available HCV protease inhibitors. In conclusion, HCV-1b was predominant in the present Albanian population, as in southeastern Europe.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Hepatitis C virus genotypes in Tirana, Albania

Haldeda

Baume

Tamalet

et al. 2014

International Journal of Infectious Diseases

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“…With the introduction of HBV vaccination, systematic screening of blood and blood products and of pregnant women, socioeconomic improvements, and the increased awareness of the general public on sexually transmissible agents, the prevalence of HDV has been reduced dramatically in some parts of the World such as Italy, Spain, Taiwan and Turkey. Thus, some authorities predict that HDV might be cleared from the Globe [13,15,17]. However, HDV remains present across the globe [18,19] with new infection in some continents increasing as a consequence of migration of infected individuals [13,20].…”

Section: Epidemiologymentioning

confidence: 99%

Hepatitis D Virus: An Overview for Dentists

Mahboobi

Porter

Rizzetto

et al. 2019

JAMMR

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Hepatitis D is considered to be the most severe form of viral hepatitis. This virus requires hepatitis B for its life cycle and it is estimated that at least 5% of hepatitis B virus infected patients are also infected with hepatitis D, counting for 15 million infections worldwide most optimistically. Hepatitis D has a similar transmission pattern to hepatitis B and hepatitis C viruses. However, there is less information about the virus of hepatitis D than about the other agents of viral hepatitis. In particular, there is total lack of information on hepatitis D in the setting of dental diseases and management. To our knowledge, there are only few reports on hepatitis D of dental health care workers (DHCW), the association of hepatitis D with oral conditions and on the role of oral fluid in transmission of hepatitis D. The present report reviews current knowledge of hepatitis D for dentists and dental personnel. Therefore, epidemiology, transmission modes, sign and symptoms, diagnostic methods and treatment options of hepatitis D are discussed under relevant subheadings.

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“…The initial conditions for the formation of liver cir-rhosis in Albanian residents are the high prevalence of hepatitis B virus in the 1990s [3,4]. In 2005, the role of viral hepatitis as a cause of chronic liver disease slightly decreased compared to 1995, but the number of alcoholic liver diseases increased significantly, from 35 % in 1995 to 57 % in 2005 [5].…”

Section: Introductionmentioning

confidence: 99%

Decompensated liver cirrhosis: assessment of complications and mortality in hospitalised patients

Cuko,

Sadiku,

Hysenj

et al. 2024

GASTRO

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Background. Liver cirrhosis is a severe, progressively fatal disease if untreated. Hospitalised patients face high mortality rates, and current methods for assessing prognosis vary widely. The research aims to investigate complications and predictors of mortality in patients admitted for decompensated cirrhosis to a tertiary care centre in Tirana, Albania. Materials and methods. The retrospective study included 212 patients aged (58.67 ± 10.09) years: 174 (82.1 %) men, 38 (17.9 %) women. The Child-Turcotte-Pugh, MELD, MELD-Na, MELD 3.0, iMELD, MESO, and UKELD scales were used to assess the severity of the condition and risk stratification of patients. The number of patients with a fatal outcome was 43 (20.3 %). Results. Among participants with different etiological factors of liver cirrhosis, the mortality rate did not differ significantly (p = 0.873). The presence of hepatic encephalopathy (0.43; p = 0.001), acute-on-chronic liver failure (r = 0.47; p = 0.001) and hepatorenal syndrome (r = 0.49; p = 0.001), and, to a lesser extent, ascites (r = 0.18; p = 0.006) and spontaneous bacterial peritonitis (r = 0.23; p = 0.041) was a marker of unfavourable prognosis of hospitalisation. Also, the risk of death increased in the presence of leukaemia (hazard ratio = 4.21 (1.65; 10.74); p = 0.003). Conclusions. The MELD 3.0 and MELD-Na scores, calculated based on laboratory values obtained within 48–72 hours of hospitalisation, were found to be the prognostically significant (p < 0.05)

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Hepatitis B, C and Delta virus infections in Albanian patients with chronic liver disease: evaluation of possible changes during the last 10 years

Cited by 11 publications

References 15 publications

Hepatitis C virus genotypes in Tirana, Albania

Hepatitis C virus genotypes in Tirana, Albania

Hepatitis D Virus: An Overview for Dentists

Decompensated liver cirrhosis: assessment of complications and mortality in hospitalised patients

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