Hepatitis B and the dental surgeon

Electron and Immunoelectron Microscopic Procedures for Diagnosis of Viral Infections

“…The use of the electron microscope in smallpox diagnosis was first indicated, in 1948, by van Rooyen and Scott and by Nagler and Rake; it is probably in the differential diagnosis of chicken pox and smallpox* that the electron microscope is best known in diagnostic virol- ogy. Thus electron microscopy now provides the method of choice in the rapid detection of poxviruses and herpesviruses (Peters et al, 1962;Almeida et al, 1962;Smith and Melnick, 1962;Nagington, 1964;Cruickshank et al, 1966;Macrae et al, 1969;Bland et al, 1970;Gibbs et al, 1970), although for specific identification it is still necessary to compliment morphological detection with virus isolation and identification procedures (Long, 1970).…”

“…The first use of the electron microscope as a diagnostic instrument in virology was reported by Nagler and Rake (1948) and van Rooyen and Scott (1948), who demonstrated that virus particles could be identified in clinical specimens from patients affected with smallpox, vaccinia, and varicella. Virologists were slow to adopt this approach, and it was more than a decade before the electron microscope was finally being used in the differential diagnosis of smallpox and chicken pox (Peters et al, 1962;Nagington, 1964;Cruickshank et al, 1966).…”