Hepatitis B and Renal Disease

Chan, Tak Mao

doi:10.1007/s11901-010-0042-6

Cited by 55 publications

(36 citation statements)

References 48 publications

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“…Unexpectedly, we observed hypermethylation of the P1 region in normal kidney tissue (Fig. b), and it is known that chronic hepatitis B virus/hepatitis C virus are both associated with glomerular disease . So, it is possible that the methylated P1 DNA detected in urine could be partially coming from the kidney, even though we only used LMW urine DNA as the substrate.…”

Section: Discussionmentioning

confidence: 74%

Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis

Jain

Xie

Boldbaatar

et al. 2014

Hepatology Research

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Aim Aberrant methylation of the promoter, P2, and the first exon, E1, regions of the tumor suppressor gene RASSF1A, have been associated with hepatocellular carcinoma (HCC), albeit with poor specificity. This study analyzed the methylation profiles of P1, P2 and E1 regions of the gene to identify the region of which methylation most specifically corresponds to HCC and to evaluate the potential of this methylated region as a biomarker in urine for HCC screening. Methods Bisulfite DNA sequencing and quantitative methylation-specific polymerase chain reaction assays were performed to compare methylation of the 56 CpG sites in regions P1, P2 and E1 in DNA isolated from normal, hepatitic, cirrhotic, adjacent non-HCC, and HCC liver tissue and urine samples for the characterization of hypermethylation of the RASSF1A gene as a biomarker for HCC screening. Results In tissue, comparing HCC (n = 120) with cirrhosis and hepatitis together (n = 70), methylation of P1 had an area under the receiver operating characteristics curve (AUROC) of 0.90, whereas methylation of E1 and P2 had AUROC of 0.84 and 0.72, respectively. At 90% sensitivity, specificity for P1 methylation was 72.9% versus 38.6% for E1 and 27.1% for P2. Methylated P1 DNA was detected in urine in association with cirrhosis and HCC. It had a sensitivity of 81.8% for α-fetoprotein negative HCC. Conclusion Among the three regions analyzed, methylation of P1 is the most specific for HCC and holds great promise as a DNA marker in urine for screening of cirrhosis and HCC.

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Section: Discussionmentioning

confidence: 74%

Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis

Jain

Xie

Boldbaatar

et al. 2014

Hepatology Research

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“…For this, there are some potential explanations. First, in hepatitis B patients, the host's immune response to HBV is active (12,13), and plays a major role in the pathogenesis of both hepatitis B and HBV-associated nephropathy (6,7,12,13). Deposition of immune complex of HBV antigenantibody is universal in HBV-associated nephropathy.…”

Section: Discussionmentioning

confidence: 99%

“…Deposition of immune complex of HBV antigenantibody is universal in HBV-associated nephropathy. It leads to both glomerular and interstitial tubular damage, clinically presenting as macroalbuminuria and decline in renal function (6,7). Second, HBV replication in hepatitis B patients (12,13) may promote apoptosis of renal tubular cells and subsequently contributes to renal function deterioration (29).…”

Section: Discussionmentioning

confidence: 99%

“…Worldwide, .350 million people are chronic HBV carriers (5). Apart from liver involvement, HBV infection can lead to HBV-associated nephropathy (6,7), yet population-based or case-control studies have not shown the expected association between HBV infection and reduced renal function, CKD, or proteinuria (8)(9)(10)(11). However, a case-control study revealed that urine albumin excretion in children with hepatitis B was significantly higher than in inactive HBV carriers and non-HBV carriers (12).…”

Section: Introductionmentioning

confidence: 99%

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Association of Reduced Renal Function with Hepatitis B Virus Infection and Elevated Alanine Aminotransferase

Cai

Fan

Mou

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Clinically, hepatitis B virus (HBV) infection is observed to be associated with nephropathy. However, previous population-based studies failed to show an association between HBV infection and CKD. Therefore, this cross-sectional study was designed to further explore this association.Design, setting, participants, & measurements A representative sample of 6854 Chinese adults aged 30-75 years was tested for levels of serum hepatitis B surface antigen, alanine aminotransferase (ALT), creatinine, urinary albumin/creatinine ratio, and potential CKD risk factors.Results Neither HBV infection nor elevated ALT (ALT+; $ sex-specific 90th percentile of ALT levels of noninfected persons) was significantly associated with reduced estimated GFR (eGFR , 60 ml/min per 1.73 m 2 ). Compared with noninfected persons, HBV-infected persons with ALT+, but not those with ALT2 (P=0.26), were more likely to have reduced eGFR (odds ratio, 4.07; 95% confidence interval, 1.18-14.0; P=0.03). Further analysis with a general linear model revealed a significant difference in eGFR (mean 6 SEM) between HBV-infected and noninfected persons (87.860.8 versus 90.260.4 ml/min per 1.73 m 2 ; P=0.002). This difference was mainly derived from that between HBV-infected persons with ALT+ and noninfected persons, with an average difference in eGFR of 24.5 (95% confidence interval, 20.9 to 28.1; P=0.01). HBV infection and ALT+, alone or in combination, were not significantly associated with albuminuria or CKD.Conclusions HBV infection with elevated ALT, rather than HBV infection alone, was associated with reduced renal function.

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“…Several forms of renal disease secondary to hepatitis B infection have been identified including membranous glomerulonephritis, mesangioproliferative glomerulonephritis, as well as IgA nephropathy and focal segmental glomerulosclerosis (FSGS) [89]. Hepatitis B has also been linked with polyarteritis nodosa (PAN).…”

Section: Patterns Of Hepatitis B Virus Immunologically Mediated Renalmentioning

confidence: 99%

Infectious Diseases and the Kidney in Children

Stevens¹,

Herberg²,

Levin³

2014

Pediatric Nephrology

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Hepatitis B and Renal Disease

Cited by 55 publications

References 48 publications

Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis

Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis

Association of Reduced Renal Function with Hepatitis B Virus Infection and Elevated Alanine Aminotransferase

Infectious Diseases and the Kidney in Children

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