Hepatitis B and C prevalence among heroin addicts in methadone maintenance treatment (MMT) and not in MMT in Pereira, Colombia

Sepúlveda-Arias, Juan Carlos; Isaza, Carlos; Vélez, Juan Pablo

doi:10.3855/jidc.4525

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…There are few studies on hepatitis C in Colombia 32 , and this investigation identified a significant number of injection drugs users who share and reuse injection equipment, similarly to what was observed in other cities of Colombia in 2010 [33][34][35] ; widely documented and discussed factors in other countries, though for Colombia, represent the first step toward intervention strategies 36 . Co-infections of HIV and HCV have been reported among drug users in different countries.…”

Section: Discusionsupporting

confidence: 62%

Uso de heroína inyectada y el riesgo de hepatitis C en tres ciudades de Colombia

Fernández

Segura-Cardona

Montoya-Vélez

et al. 2017

Rev. bras. epidemiol.

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ABSTRACT:Introduction: Hepatitis C is one of the most neglected diseases by governments internationally. Objective: Identify the prevalence of hepatitis C and associated injection drug users in three cities of factors Colombia. Methods: Cross-sectional study of 668 injecting drug users recruited through respondent-driven sampling, inquired about demographic characteristics and risk behaviors. Laboratory testing was used on filter paper and cases of hepatitis C viral load tests with RNA were confirmed. Hepatitis C prevalence and associated factors was estimated with Chi-square test statistics and reasons for crude and adjusted prevalence were calculated using logistic regression. Results: The prevalence of hepatitis C was 17.5% and were found as factors that increase the prevalence of hepatitis: having HIV, injecting another person carrying the virus dose used was sharing a syringe, injected with a syringe and consume marijuana. As a factor that reduces the prevalence, purchase syringes in drug stores or other stores. Conclusion: This research evidence established consumption of drugs by injection , and the presence of hepatitis C in social networks of IDUs and highlights the importance of developing interventions for harm reduction and prevention of hepatitis C in this population these three cities.

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Section: Discusionsupporting

confidence: 62%

Uso de heroína inyectada y el riesgo de hepatitis C en tres ciudades de Colombia

Fernández

Segura-Cardona

Montoya-Vélez

et al. 2017

Rev. bras. epidemiol.

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“…En Colombia, se ha determinado la prevalencia de la enfermedad en algunos grupos de riesgo, y se ha observado un incremento de los casos en quienes recibieron transfusiones antes de 1994 (6,7), en pacientes con enfermedad renal crónica terminal (8), en adictos al uso de drogas por vía parenteral (9,10), entre el personal sanitario (11,12) y en población indígena (12,13). Sin embargo, la persistente búsqueda de personas infectadas en los grupos de riesgo tradicionales no ha permitido detectar otros factores potencialmente implicados en el contagio.…”

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“…Por otra parte, la prevalencia de la hepatitis C en algunas poblaciones de riesgo no ha sido uniforme en las diferentes zonas del país (9,10,12,13), lo cual implica que los factores asociados a la infección pueden variar en función de diferencias geográficas y culturales.…”

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Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control study

Yepes

Lince

Caez³

et al. 2016

biomedica

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Contribución de los autores:Ismael de Jesús Yepes: coordinación del protocolo de investigación y análisis de la información Todos los autores participaron en el diseño del protocolo, la selección de pacientes y la redacción del manuscrito.Factores de riesgo para la infección por el virus de la hepatitis C en la Costa Caribe colombiana: un estudio de casos y controles Introducción. Se estima que, aproximadamente, 6,8 a 8,9 millones de personas están infectadas por el virus de la hepatitis C en Latinoamérica, de las cuales menos del 1 % llega a recibir tratamiento antiviral. En los estudios llevados a cabo hasta ahora en Colombia, se ha propuesto determinar la prevalencia de la enfermedad en algunos grupos de riesgo, y no se ha hecho el análisis de otros factores potencialmente implicados en el contagio. Objetivos. Determinar los factores de riesgo tradicionalmente analizados y otros no estudiados antes para la hepatitis C crónica en la Costa Caribe colombiana. Materiales y métodos. Se hizo un estudio de casos y controles (1:3) emparejados por empresa promotora de salud y edad (± 10 años), en el primer nivel de atención de hepatología y gastroenterología. A todos los pacientes positivos en la prueba ELISA se les hizo una prueba confirmatoria de carga viral. En el análisis de regresión logística multivariable se determinaron los factores predictores independientes de infección. Resultados. La transfusión sanguínea (odds ratio, OR=159,2; IC 95% 35,4-715; p<0,001) y el antecedente de hospitalización antes de 1994 (OR=4,7; IC 95% 1,3-17,1; p=0,018) se determinaron como los dos únicos factores independientes predictores de infección. Conclusión. Es necesario comprobar la reproducibilidad de estos resultados y hacer estudios de costo-efectividad antes de recomendar su utilización en el diseño de nuevas estrategias de cribado.Palabras clave: hepatitis C; factores de riesgo; estudios de casos; transfusión sanguínea; región del Caribe; Colombia. doi: http://dx.doi.org/10.7705/biomedica.v36i4.3105 Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control studyIntroduction: An estimated 6.8-8.9 million people are infected with hepatitis C virus in Latin America, of which less than 1% receives antiviral treatment. Studies so far in Colombia have attempted to determine the prevalence of the disease in some risk groups, thus preventing the identification of other factors potentially involved in the spread of the infection. Objectives: To identify traditional and non-traditional risk factors for chronic hepatitis C in the Colombian Caribbean coast. Materials and methods: This was a case-control study (1:3) matched by health care provider and age (± 10 years) conducted at the primary care level of gastroenterology and hepatology outpatient services. All patients with a positive ELISA underwent a confirmatory viral load test. A multivariate logistic regression analysis identified the independent predictors of infection. Results: Blood transfusion (OR=159.2; 95% CI: 35.4-715; p<0.001) and history...

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“…However, some MMT patients are still at risk of craving heroin; these patients may relapse to heroin abuse, which may adversely affect their HRQoL [38,39]. Third, patients with syringe sharing are at high risk of HIV, HCV, or hepatitis B virus (HBV) infection that can lead to acquired immunodeficiency virus, chronic hepatitis C, or chronic hepatitis B, respectively, which would also deteriorate the HRQoL [34,40,41]. Therefore, the side effects of methadone should be carefully considered and addressed during long-term MMT.…”

Section: Discussionmentioning

confidence: 99%

Bidirectional relationships between retention and health-related quality of life in Chinese mainland patients receiving methadone maintenance treatment

Zhou

Wang

et al. 2017

PLoS ONE

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This study aimed to explore the bidirectional relationships between retention and health-related quality of life (HRQoL) in patients from mainland China receiving methadone maintenance treatment (MMT). This prospective cohort study recruited 1,212 eligible MMT patients from the two largest MMT clinics (one privately and another publicly funded) in Xi’an. This study started in March 2012 with a 2-year follow-up until March 2014. Retention was assessed by repeated terminations, past treatment duration, premature terminations, and follow-up treatment duration. HRQoL was evaluated using the Chinese (simple) short-form 36 health survey version 2 (SF-36v2) and the quality of life scale for drug addicts (QOL-DAv2.0). Linear and Cox regression analyses were used to explore relationships between retention and HRQoL. A general linear model was used to further examine the global effect of past treatment duration on HRQoL. Multivariate analyses showed that repeated terminations had no significant impact on HRQoL scores in MMT patients; however, past treatment time (year) influenced the SF-36v2PCS (P = 0.004): treatment for ≥4 years showed a lower SF-36v2PCS score (regression coefficient: -2.39; 95% confidence interval [CI]: -3.80, -0.97; P = 0.001) than treatment for <1 year. In addition, patients with an SF-36v2PCS score > 49 (hazard ratio: 0.83; 95% CI: 0.69, 0.98; P = 0.03) were 17% less likely to terminate MMT than those with scores of ≤49. In conclusion, retention and HRQoL tended to have a bidirectional relationship, which should be considered in the development of retention and health-management programs for patients with MMT.

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Hepatitis B and C prevalence among heroin addicts in methadone maintenance treatment (MMT) and not in MMT in Pereira, Colombia

Abstract: This item has no abstract. Follow the links below to access the full text.

Cited by 9 publications

References 10 publications

Uso de heroína inyectada y el riesgo de hepatitis C en tres ciudades de Colombia

Uso de heroína inyectada y el riesgo de hepatitis C en tres ciudades de Colombia

Risk factors for hepatitis C virus infection in the Colombian Caribbean coast: A case-control study

Bidirectional relationships between retention and health-related quality of life in Chinese mainland patients receiving methadone maintenance treatment

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