Hepatitis autoinmune desencadenada tras el consumo de bayas de Goji

Franco, M.A. Díaz; Monmany, J.; Domingo, Peré; Turbau, Miquel

doi:10.1016/j.medcli.2012.02.009

Cited by 5 publications

(2 citation statements)

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“…Anthraquinones, the chemical components of aloe, are reputed toxic that lead to the production of oxygen-derived free radicals that eventually induce apoptosis (Kågedal et al 1999). Goji berry, the fruit of Lycium barbarum L., has been recently involved in hepatitis too (Franco et al 2012;Arroyo-Martinez et al 2011). Finally, many reports of suspected liver injuries from noni (Morinda citrifolia L.) are reported (Waldman et al 2013;Yu et al 2011;Stadlbauer et al 2008;López-Cepero Andrada et al 2007;Yuce et al 2006;Stadlbauer et al 2005;Millonig et al 2005), even if hepatotoxicity of noni juice remains speculative (Mrzljak et al 2013;West and Deng 2011).…”

Section: Discussionmentioning

confidence: 99%

Hepatotoxicity of green tea: an update

2015

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Green tea (GT), obtained from the leaves of Camellia sinensis (L.) Kuntze (Fam. Theaceae), is largely used for its potential health benefits such as reduction in risk of cardiovascular diseases and weight loss. Nevertheless, it is suspected to induce liver damage. Present work reviews the hepatic adverse reactions associated with GT-based herbal supplements, published by the end of 2008 to March 2015. A systematic research was carried out on PubMed, MedlinePlus, Scopus and Google Scholar databases, without any language restriction. Moreover, some accessible databases on pharmacovigilance or phytovigilance were consulted. The causality assessment was performed using the CIOMS/RUCAM score. Nineteen cases of hepatotoxicity related to the consumption of herbal products containing GT were identified. The hepatic reactions involved mostly women (16/19); the kind of liver damage was generally classified as hepatocellular (16/19). The causality assessment between consumption of herbal preparation and hepatic reaction resulted as probable in eight cases and as possible in eleven cases. In seven cases, patients used preparations containing only GT, while twelve reactions involved patients who took multicomponent preparations (MC). The reactions induced by GT had a generally long latency (179.1 ± 58.95 days), and the outcome was always resolution, with recovery time of 64.6 ± 17.78 days. On the contrary, liver injury associated with MC had a shorter latency (44.7 ± 13.85 days) and was more serious in four cases that required liver transplantation and, when resolution occurred, the recovery time was longer (118.9 ± 38.79). MC preparations contained numerous other components, many of which are suspected to induce liver damage, so it is difficult to ascribe the toxicity to one specific component, e.g., GT. Present data confirm a certain safety concern with GT, even if the number of hepatic reactions reported is low considering the great extent of use of this supplement. The mechanism of GT hepatotoxicity remains unclear, but factors related to the patient are becoming predominant. A major safety concern exists when GT is associated with other ingredients that can interact between them and with GT, enhancing the risk of liver damage. Patients should be discouraged from using herbal or dietary supplements containing complex mixtures and should be encouraged to use herbal and dietary supplement possibly under supervision of healthcare professionals.

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Section: Discussionmentioning

confidence: 99%

Hepatotoxicity of green tea: an update

2015

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“… 2 - 4 There are also rare case reports linking consumption of particular food products to the development of AIH. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

Toxin-Induced Autoimmune Hepatitis Caused by Raw Cashew Nuts

Crismale

Stueck

Bansal

2016

ACG Case Reports Journal

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A 64-year-old man with no past medical history presented with abnormally elevated liver enzymes 1 year after developing a diffuse rash thought to be related to eating large quantities of raw cashew nuts. Liver biopsy was performed, which revealed features concerning for drug- or toxin-induced autoimmune hepatitis. The patient began treatment with azathioprine and prednisone, and liver enzymes normalized. We describe a unique case of a toxin-induced autoimmune hepatitis precipitated not by a drug or dietary supplement but by a food product.

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Euforia-induced acute hepatitis in a patient with scleroderma

et al. 2012

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Euforia, a supplement containing a variety of natural ingredients, is widely used as an antioxidant and anti-inflammatory formula. It is not approved by the US Food and Drug Administration and its side effects are unknown. We report a 45-year-old woman with limited systemic sclerosis who presented with jaundice and marked elevation of serum transaminases. One month before, she started taking Euforia juice. A liver biopsy disclosed submassive hepatocellular necrosis with histopathological changes consistent with toxic hepatitis. The patient's symptoms resolved with cessation of Euforia. Six months later, she persisted with abnormal liver function tests, but these resolved 18 months after discontinuation of Euforia. The mechanism by which Euforia causes liver injury is unknown. Some ingredients contained in this supplement (green tea, Aloe vera, noni and goji) are linked to hepatic injury. To our knowledge, this is the first report of hepatotoxicity associated with Euforia.

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Hepatitis autoinmune desencadenada tras el consumo de bayas de Goji

Cited by 5 publications

References 5 publications

Hepatotoxicity of green tea: an update

Hepatotoxicity of green tea: an update

Toxin-Induced Autoimmune Hepatitis Caused by Raw Cashew Nuts

Euforia-induced acute hepatitis in a patient with scleroderma

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