Hepatitis Associated with Disseminated Lupus Erythematosus

Appelbaum, Jerry J.; Job, Henry; Kern, Fred

doi:10.1016/s0016-5085(61)80048-6

Cited by 17 publications

(1 citation statement)

References 10 publications

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“…In some instances, separation of true lupus with coincidental viral hepatitis from chronic ac tive hepatitis with LE phenomena is difficult (96)(97)(98)(99)(100). This has led some to believe that the hepatitis is merely a phase of lupus (99).…”

Section: Perpetuating Mechanismsmentioning

confidence: 99%

Chronic Hepatitis

F¹,

Klion²

1968

Annu. Rev. Med.

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Section: Perpetuating Mechanismsmentioning

confidence: 99%

Chronic Hepatitis

F¹,

Klion²

1968

Annu. Rev. Med.

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Serologic Abnormalities in Systemic Lupus Erythematosus Associated with Viral Hepatitis and Tuberculosis

Salisbury¹,

Plötz²,

Holland³

et al. 1973

Arthritis & Rheumatism

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A 38-year-old Turkish woman with the clinical diagnosis of systemic lupus erythematosus but with negative LE cell tests developed a positive LE cell test and anti-DNA and anti-RNA antibodies coincident to manifestations of serum hepatitis. Tuberculosis, present at the same time, may have been an additional factor.It has often been suggested that systemic lupus erythematosus (SLE) and other autoimmune diseases are the result of altered immunity to naturally occurring viral infections. There are increased titers of antibodies to several groups of human viral pathogens in patients with SLE (1-3), and tubuloreticular structures, possibly related to virus infection (4), are found in the kidneys (5), skin (6), liver (7) and circulating leukocytes (8) from patients with SLE. The infection of NZB/ NZW mice with some viruses accelerates the course of their lupus-like illness (O), and the anti-RNA antibodies from patients with SLE

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Concentration of serum bile acids as an index of hepatic damage in systemic lupus erythematosus

et al. 1984

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The aim of this work is to evaluate the concentration of serum bile acids (SBA) as an index of impaired liver function in systemic lupus erythematosus (SLE) patients versus usual laboratory tests of hepato-biliary system diseases. In patients with SLE the mean fasting SBA concentration was 9.6 +/- 1.4 mumol/L; in normal subjects the concentration was 2.9 +/- 0.6 mumol/L (P less than 0.01). In patients with SLE, mean gamma-glutamyl transpeptidase (GGTP) concentration was 31.5 +/- 5.9 mU/ml versus 10.05 +/- 1.1 mU/ml in controls (P less than 0.01). The bromsulphalein (BSP) excretion test, 45 minutes after injection, was 6.8 +/- 1% in SLE patients versus 2.8 +/- 0.4% in controls (P less than 0.02). No significant difference was found between these two groups of subjects with respect to leucine aminopeptidase (LAP), alkaline phosphatase (AlPh), glutamic-oxalacetic transaminase (SGOT), glutamic-pyruvic transaminase (SGPT), bilirubin serum rates. SBA rate was abnormal in 50% of the SLE patients; GGTP rate and the BSP excretion test were abnormal in 38% and 27% respectively. Our findings show the presence of an actual liver impairment in SLE patients, significantly demonstrated by fasting SBA concentration, GGTP rate and BSP excretion test. Other liver function tests are less useful in evaluating hepatic damage in SLE.

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Hepatitis Associated with Disseminated Lupus Erythematosus

Cited by 17 publications

References 10 publications

Chronic Hepatitis

Chronic Hepatitis

Serologic Abnormalities in Systemic Lupus Erythematosus Associated with Viral Hepatitis and Tuberculosis

Concentration of serum bile acids as an index of hepatic damage in systemic lupus erythematosus

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