Hepatitis A virus infection in hepatitis C Brazilian patients

Devalle, Sylvie; Paula, Vanessa Salete de; Oliveira, J. M.; Niel, Christian; Gaspar, Ana

doi:10.1016/s0163-4453(03)00061-6

Cited by 20 publications

(21 citation statements)

References 23 publications

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“…In this report we observed the co-circulation of subgenotypes IA and IB. In previous studies both genotypes have been detected in samples collected in Rio de Janeiro (15,27), confirming that both genotypes are present in this region. Similarly, in an outbreak in Spain, genotypes IA and IB were found in clinical samples at a proportion of 50% each.…”

Section: Discussionsupporting

confidence: 73%

Genetic variability of hepatitis A virus isolates in Rio de Janeiro: implications for the vaccination of school children

Villar

Lampe

Meyer

et al. 2004

Braz J Med Biol Res

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The epidemiology of hepatitis A virus (HAV) infection is shifting from high to intermediate endemicity in Brazil, resulting in increased numbers of susceptible individuals and a greater potential for the emergence of outbreaks. Universal vaccination against HAV has been recommended for children, but updated sero-epidemiological data are necessary to analyze the level of natural immunity and to identify candidates for preventive measures. In addition, more molecular studies are necessary to characterize the genotypes involved in HAV infections and outbreaks. Sera from 299 school children (5-15 years old) and 25 school staff members, collected during an outbreak of HAV at a rural public school in June 2000, were tested for IgM and total anti-HAV antibodies (ELISA). Viral RNA was amplified by RT-PCR from anti-HAV IgM-positive sera and from 19 fecal samples. Direct nucleotide sequencing of the VP1/2A region was carried out on 18 PCR-positive samples. Acute HAV infection was detected by anti-HAV IgM in 93/299 children and in 3/25 adult staff members. The prevalence of total anti-HAV antibodies in IgM-negative children under 5 years of age was only 10.5%. HAV-RNA was detected in 46% IgM-positive serum samples and in 16% stool samples. Sequence analysis showed that half the isolates belonged to subgenotype IA and the other half to IB. On the basis of these data, mass vaccination against HAV is recommended without prevaccination screening, especially for children before they enter school, since nearly 90% of the children under 5 years were susceptible. Molecular characterization indicated the endemic circulation of specific HAV strains belonging to subgenotypes IA and IB.

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Section: Discussionsupporting

confidence: 73%

Genetic variability of hepatitis A virus isolates in Rio de Janeiro: implications for the vaccination of school children

Villar

Lampe

Meyer

et al. 2004

Braz J Med Biol Res

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“…18 However, these results are higher than those observed in patients with HCV infection (mean age of 44.8 years), in the city of Rio de Janeiro (86%), leading authors of this other study to recommend implementation of hepatitis A vaccination for this population. 19 Thus, despite the observed changes in the HA epidemiology from high to intermediate endemicity in the Southeastern Brazil, the high seroprevalence of anti-HAV antibodies in adult patients with LC observed in the present study shows that routine HA vaccination could not be implemented for this patients. In addition, the serological test for total anti-HAV detection by ELISA method is five times cheaper than complete vaccination against hepatitis A [R$ 35.00 (US$ 19.4) versus R$ 180.00 (US$ 100), respectively], and, for these reasons, the screening for HAV antibody before vaccination could be recommended for adult patients with chronic liver disease due to its higher cost-effectiveness.…”

Section: Discussioncontrasting

confidence: 68%

Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?

Oliveira¹,

Comácio²,

Santos³

2011

Braz J Infect Dis

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BACKGROUND: Patients with chronic liver disease have a higher risk of fulminant hepatitis when infected with hepatitis A virus, and vaccination of these patients against such infection is recommended. In Brazil, mainly in the South and Southeast regions, the epidemiology of hepatitis A (HA) has shifted from high to intermediate endemicity, which would have implication on policy of HA vaccination for these populations. OBJECTIVE: To verify the prevalence of HA immunity in adult patients with liver cirrhosis (LC), in Uberlândia MG, a city of Southeastern Brazil. METHODS: Between December 2005 and December 2006, 106 patients with LC were consecutively evaluated. In addition, 75 individuals without LC or alcoholism were evaluated (control group - CG). RESULTS: Total anti-HAV (ELISA methods) was positive in 104 (98.1%) patients with LC (82 men, 24 women; mean age, 53.3 ± 11.9 years) and in 74 (98.7%) individuals of the CG (55 men, 20 women; mean age, 47 ± 11.6 years), p > 0.05. CONCLUSIONS: For patients with chronic liver disease, in the geographic regions and age groups evaluated, routine vaccination against hepatitis A is not recommended. Moreover, the serum determination of total anti-HAV, used to assess immunity, is five times cheaper than vaccination against hepatitis A and, for this reason, should precede vaccination

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“…This demonstrates that a genotype I infection has an endemic character in Brazil, although it is the only South American country in which the circulation of both subgenotypes IA and IB has been reported (de Paula et al 2002, Devalle et al 2003, Villar et al 2004. However, this study differs from that of de , in which the analysis of the nucleotide sequence of the VP1/2A junction region showed the occurrence of only subgenotype IA in isolates from the state of Goiás.…”

Section: Discussioncontrasting

confidence: 62%

“…In Brazil, the only genotype that has been found is genotype I, especially subgenotype IA ). However, subgenotype IB has also been observed to circulate in the states of Rio de Janeiro and Pernambuco and in the Amazon region (de Paula et al 2002, Devalle et al 2003, Villar et al 2004.…”

mentioning

confidence: 99%

Molecular characterization of hepatitis A virus isolates from Goiânia, Goiás, Brazil

Fiaccadori

Pereira

Coelho

et al. 2008

Mem. Inst. Oswaldo Cruz

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Hepatitis A virus infection in hepatitis C Brazilian patients

Cited by 20 publications

References 23 publications

Genetic variability of hepatitis A virus isolates in Rio de Janeiro: implications for the vaccination of school children

Genetic variability of hepatitis A virus isolates in Rio de Janeiro: implications for the vaccination of school children

Seroprevalence of hepatitis A immunity among brazilian adult patients with liver cirrhosis: is HAV vaccination necessary?

Molecular characterization of hepatitis A virus isolates from Goiânia, Goiás, Brazil

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