Hepatitis A virus infection

Van Damme, Pierre; Pintó, Rosa M.; Feng, Zongdi; Cui, Fuqiang; Gentile, Angela; Shouval, Daniel

doi:10.1038/s41572-023-00461-2

Cited by 13 publications

(7 citation statements)

References 220 publications

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“…Moreover, from this analyzed population, 344 patients (2.0%) were born after the mandatory HAV vaccine implementation in 2005, and 16,638 (98.0%) were born before. The median age (Q1-Q3) of the patients reached by the vaccine implementation was 6 years (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and 163 (47.4%) were women. The age of those not reached by the vaccine was 38 years (28-53), with 9,151 (55%) being women.…”

Section: Characteristics Of the Study Populationmentioning

confidence: 99%

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Seroprevalence of hepatitis A virus among people born before and after implementation of universal vaccination in Argentina

Flichman,

Ridruejo,

Grosso

et al. 2024

Infectious Diseases

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Section: Characteristics Of the Study Populationmentioning

confidence: 99%

“…The hepatitis A virus (HAV) is transmitted mainly by the fecal-oral route as a result of ingesting contaminated water or food, although it can also be transmitted through direct contact with an infected person [2].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of hepatitis A virus among people born before and after implementation of universal vaccination in Argentina

Flichman,

Ridruejo,

Grosso

et al. 2024

Infectious Diseases

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“…Hepatitis A is caused by a nonenveloped, positive-sense, single-stranded RNA virus (HAV) with a 7.5 kb genome, represented by one serotype and seven genotypes [ 1 ]. It is globally prevalent and remains the most common form of acute viral hepatitis worldwide [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Trends of Hepatitis A Virus Infection in Poland: Assessing the Potential Impact of the COVID-19 Pandemic and War in Ukraine

Rzymski,

Zarębska-Michaluk,

Genowska

et al. 2024

Viruses

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Hepatitis A virus (HAV) is the most common cause of acute viral hepatitis, which is preventable by vaccination. This study analyzed trends of HAV infections in Poland according to socio-demographic features in the years 2009–2022 and assessed the potential impact of the COVID-19 pandemic (2020–2023) and the migration of war refugees from Ukraine (since February 2022). In 2009–2022, 7115 new cases of HAV infection were diagnosed in Poland, especially among men (66.4%) and in urban areas (77.4%). Infections among men were most common at the age of 25–34 (median rate 0.43 per 105) and in women aged 15–24 (median rate 0.39 per 105). Analysis of the 14-year frequency of HAV infections exhibited three trends, regardless of gender, age, and residence. The infections revealed a downward trend in 2009–2014, increased significantly in 2014–2018, and decreased again after 2018. A particularly rapid increase in HAV infections occurred between March 2017 and February 2018 (median rate 0.79 per 105). The high level of new infections persisted until the beginning of the COVID-19 pandemic, at which point it dropped significantly but did not reach the level recorded before March 2017. During the Omicron SARS-CoV-2 dominance period, the median rate of HAV infections was 0.053 per 105, with a four-fold increase being observed from February 2022 (when the migration of war refugees from Ukraine began) to August 2022. The presented results can serve as a reference point for further observations in Central Europe. The HAV epidemiological situation is unlikely to escalate in Poland but requires further monitoring.

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“…HAV is a member of the Hepatovirus genus, belonging to the family Picornaviridae, and causes acute viral hepatitis. Based on the capsid nucleotide variability, three genotypes (I, II, and III) and six subgenotypes (IA, IB, IIA, IIB, IIIA, and IIIB) of HAV have been described [16]. The primary mechanism of transmission of HAV is the fecal-oral route and direct contact with an infected person [17].…”

Section: Introductionmentioning

confidence: 99%

“…The global distribution of hepatitis A is divided into nonendemic countries and endemic countries. Non-endemic regions are usually high-income countries with improved hygienic-sanitary conditions, whereas endemic regions typically correspond to low-income countries with poor water sanitation [16].…”

Section: Introductionmentioning

confidence: 99%

Dynamic and Seasonal Distribution of Enteric Viruses in Surface and Well Water in Riyadh (Saudi Arabia)

Abid,

Blanco,

Al-Otaibi

et al. 2023

Pathogens

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Enteric viruses are the major cause of gastroenteritis and enteric hepatitis worldwide, but in some areas like Saudi Arabia, little is known about their presence in water sources. The available information from clinical samples is not enough to figure out their actual prevalence. The aim of this study was to gather information for the first time in Saudi Arabia on the presence of the Norovirus (NoV) genogroup GI and GII, hepatitis A virus (HAV), and hepatitis E virus (HEV) in water. For this purpose, thirteen monthly samples were collected from Lake Wadi Hanifa and surrounding wells from December 2014 to November 2015. Viruses were detected and quantified using real-time RT-qPCR. Despite HEV findings being anecdotic, our results highlight interesting behaviors of the other viruses. There was a higher prevalence of noroviruses in Wadi Hanifa samples than in well water samples (46.43% vs. 12.5% of NoV GI; 66.67% vs. 8.33% of NoV GII). On the contrary, similar levels of HAV positivity were observed (40.48% in surface water vs. 43.06% in well water). Also, a strong influence of flooding events on HAV and NoV GI occurrence was observed in both surface and well water samples, with NoV GII apparently not affected.

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Hepatitis A virus infection

Cited by 13 publications

References 220 publications

Seroprevalence of hepatitis A virus among people born before and after implementation of universal vaccination in Argentina

Seroprevalence of hepatitis A virus among people born before and after implementation of universal vaccination in Argentina

Trends of Hepatitis A Virus Infection in Poland: Assessing the Potential Impact of the COVID-19 Pandemic and War in Ukraine

Dynamic and Seasonal Distribution of Enteric Viruses in Surface and Well Water in Riyadh (Saudi Arabia)

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