Hepatitis A vaccine responses in HIV-positive persons with haemophilia

Loss of hepatitis A virus (HAV) antibodies after peripheral stem cell transplantation (PSCT)

“…Although there are no studies regarding immunogenicity of this vaccine among PSCT recipients, it has been shown to be safe and immunogenic in other immunocompromised hosts. [23][24][25][26][27] In conclusion, 14% of nonvaccinated anti-HAV seropositive patients can lose these antibodies 1 year following PSCT. We recommend immunizing these patients.…”

Determinants of Hepatitis A Vaccine Immunity in a Cohort of Human Immunodeficiency Virus-Infected Children Living in Switzerland

“…In a population of pediatric patients (median age of 5.5 years) without severe symptoms or immunosuppression (all with T cell levels of Ͼ15%), Gouvea et al showed a 100% seroconversion rate (11). Otherwise, due to heterogeneity of study populations (27), results can differ, with seroconversion rates following HAV vaccination ranging from 48.5 to 94% in HIV-infected adults (16,21,22,24,33,35,39) and from 84.5 to 100% in HIVinfected children (11,25,28,30,37).…”

“…While seroconversion reaches 100% in healthy adult and pediatric individuals after 2 doses of Havrix (GlaxoSmithKline Biologicals, Rixensart, Belgium) (2), studies with adult HIV-positive patients showed significantly lower percentages (48.5 to 94%) (16,21,22,24,33,35,39). Duration of protection, currently estimated to be more than 20 years in healthy individuals (12), also seems to be shorter in HIV-positive patients (35).…”

Vaccination against hepatitis a and b in patients with hiv

“…However, response to vaccine for both HAV and HBV has been shown to vary in HIV-positive cohorts [16][17][18][19][20][21][22][23]. Individual study reported response rates have ranged from 50% [23] to 94% [20], but a recent meta-analysis of response rates to HAV vaccine in HIV-positive patients demonstrated a 64% rate of response by intention-to-treat analysis and a 71% response rate per protocol [24•].…”