Hepatitis A-associated immune thrombocytopenia

Leblebisatan, Göksel; Tümgör, Gökhan; Şaşmaz, İlgen; Özgür, Özlem; Antmen, Bülent

doi:10.4318/tjg.2012.0417

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…The occurrence of ITP due to hepatitis A virus infection is very rare. In the literature, a limited number of cases has been reported (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Although the exact mechanism is still unknown, immune-mediated thrombocytopaenia in hepatitis A infection…”

Section: Discussionmentioning

confidence: 99%

“…Immune thrombocytopenic purpura (ITP) is also a benign and self-limiting disorder which may follow a recent viral infection or immunization in childhood. Immune thrombocytopenic purpura associated with hepatitis A virus (HAV) infection has been reported only in a small number of children in the literature (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Immune thrombocytopenic purpura may be the sole manifestation of acute hepatitis A infection without other associated symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Immune Thrombocytopenic Purpura Associated with Hepatitis A Infection in A Five-Year Old Boy: A Case Report

et al. 2014

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CASE REPORTA five-year old boy was referred to the Pediatric Emergency Department of Sisli Etfal Training and Research Hospital (Istanbul, Turkey) with thrombocytopaenia. He had oral lesions during the last week and bruising on both legs, purpuric, petechial lesions on his face, trunk and extremities had appeared over the last three days before admission. His two siblings had hepatitis A infection two months previously. He had no remarkable family history of haematologic disorder. He received no drugs and had no prior hospitalizations. He had no previous immunization record against hepatitis A.On physical examination, he was alert, awake and anicteric. He had ecchymosis of the anterior aspect of both lower legs and petechiae all over his body. His weight was 15.1 kg (3−10 th centile) and height 105 cm (10-25 th centile). Body temperature (axillary) was 37.1°C. Pulse rate was 88/ minute and regular. Blood pressure was 80/40 mmHg. His oropharynx was hyperaemic and had non-ulcerated lesions. He had normal heart sounds and no murmur. Peripheral perfusion was normal. He had normal breath sounds bilaterally and respiratory rate was 16/minute.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immune Thrombocytopenic Purpura Associated with Hepatitis A Infection in A Five-Year Old Boy: A Case Report

et al. 2014

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Viral Hepatitis A in Children: Detection and Management

Sintusek

Sa-nguanmoo

Poovorawan

2019

Viral Hepatitis in Children

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Thioacetamide-induced liver damage and thrombocytopenia is associated with induction of antiplatelet autoantibody in mice

Lin

Sun

et al. 2019

Sci Rep

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Thrombocytopenia is usually associated with liver injury, elevated plasma aspartate aminotransferase and alanine aminotransferase levels, and high antiplatelet immunoglobulin (Ig) titers, although the mechanism behind these effects remains elusive. Deciphering the mechanism behind acute liver disease–associated thrombocytopenia may help solve difficulties in routine patient care, such as liver biopsy, antiviral therapy, and surgery. To determine whether liver damage is sufficient per se to elicit thrombocytopenia, thioacetamide (TAA)-induced hepatitis rodent models were employed. The analysis results indicated that TAA treatment transiently induced an elevation of antiplatelet antibody titer in both rats and mice. B-cell-deficient (BCD) mice, which have loss of antibody expression, exhibited markedly less thrombocytopenia and liver damage than wild-type controls. Because TAA still induces liver damage in BCD mice, this suggests that antiplatelet Ig is one of the pathogenic factors, which play exacerbating role in the acute phase of TAA-induced hepatitis. TNF-α was differentially regulated in wild-type versus BCD mice during TAA treatment, and anti-TNF treatment drastically ameliorated antiplatelet Ig induction, thrombocytopenia, and liver injury, suggesting that the TNF pathway plays a critical role in the disease progression.

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Hepatitis A-associated immune thrombocytopenia

Cited by 4 publications

References 5 publications

Immune Thrombocytopenic Purpura Associated with Hepatitis A Infection in A Five-Year Old Boy: A Case Report

Immune Thrombocytopenic Purpura Associated with Hepatitis A Infection in A Five-Year Old Boy: A Case Report

Viral Hepatitis A in Children: Detection and Management

Thioacetamide-induced liver damage and thrombocytopenia is associated with induction of antiplatelet autoantibody in mice

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