Hepatite C: prevalência e fatores de risco entre portadores do VIH/SIDA em Belém, Pará, na Amazônia brasileira

Monteiro, Márcia Regina Pereira; Nascimento, Margarida Maria Pásseri do; Passos, Afonso Dinis Costa; Figueiredo, José Fernando de Castro

doi:10.1590/s0037-86822004000700006

Cited by 19 publications

(11 citation statements)

References 37 publications

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“…In Brazil, about 0.5% of the adult population is infected with HIV [1] and among those attending the public health services, 16% HIV-HCV co-infection rate had been reported in outpatient care centers [2], [3], 42% in HIV-HCV anonymous testing centers [4], and 54% for patients HIV infected in infectious diseases clinics [5].…”

Section: Introductionmentioning

confidence: 99%

Co-Infection by Hepatitis C Virus in HIV-Infected Patients in Southern Brazil: Genotype Distribution and Clinical Correlates

et al. 2010

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BackgroundPrevalence rates of Hepatitis C Virus (HCV) co-infection, the distribution of HCV genotypes, and the frequency of spontaneous resolution of hepatitis C in patients infected with the Human Immunodeficiency Virus (HIV) have a worldwide disparity. The purpose of this study is to investigate the prevalence of HCV antibodies (anti-HCV) in patients with HIV, the proportion and correlates of infection by different HCV genotypes, and rates of spontaneous resolution of HCV infection.MethodsA cross-sectional study was conducted among 1143 HIV patients under follow-up in a HIV/AIDS outpatient reference center of the Brazilian public health system. From 357 anti-HCV positive patients, a consecutive sample of 227 individuals HCV treatment-naïve was interviewed and 207 was tested for HCV-RNA and genotypes.ResultsAnti-HCV was detected in 357 patients (31.2%). HCV-RNA was undetectable in 16.4% of 207 anti-HCV positive individuals. Genotype 1 was diagnosed in 81.5% of the sample, genotype 2 in 1.7% and genotype 3 in 16.2%. Male gender was the unique characteristic associated with higher prevalence of genotype 1 HCV.ConclusionsCo-infection by HCV is frequent among patients with HIV in our State, and it is particularly high the infection by HCV genotype 1. Further investigation is necessary to explain the important regional variation in the proportion of infection by the different HCV genotypes and to better understand rates of spontaneous HCV clearance.

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Section: Introductionmentioning

confidence: 99%

Co-Infection by Hepatitis C Virus in HIV-Infected Patients in Southern Brazil: Genotype Distribution and Clinical Correlates

et al. 2010

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“…In Brazil, the prevalence of HCV is around 1% to 2% in the general population, but it ranges from 0.9% to 2.4% in the North region of the country [6,7] and it reaches more than 30% among injecting drug users [8]. Seroprevalence to HCV in the Pacui Island, Para, a small village within Cameta municipality, was 8.8% and RNA persistence was detected among 62.5% of the seroreactive subjects [9].…”

Section: Introductionmentioning

confidence: 99%

Detection of HCV Persistent Infections in the Dental Pulp: A Novel Approach for the Detection of Past and Ancient Infections

Siravenha

Madeira

et al. 2016

PLoS ONE

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The dental pulp is a sterile highly vascularized tissue and has been commonly used as a biological material to detect the genome of infectious agents that reach the dental tissue. Indeed, the pulp is also used to reveal past and ancient infections in the field of paleomicrobiology. The present study aimed to detect the presence of Hepatitis C virus (HCV) in a small community (approximately 400 inhabitants) in the Amazon region of Brazil (Nossa Senhora do Perpetuo Socorro, Vizeu, Para, Brazil) and standardize a technique for the detection of the virus in the dental pulp. Serum samples were collected from 48 patients whose teeth were clinically recommended for surgical extraction. The group comprised an equal number of males and females, mostly agriculture workers and housewives, respectively. The majority (64.6%) received less than one minimum wage and were ill educated (less than four years of school years). An enzyme immune assay was used to detect antibodies to HCV and the 9 (18.8%) positive samples were submitted to nucleic acid extraction in the blood (using the EXTRAzol) and the pulp (QIAamp DNA Micro Kit e kit RNeasy Plus Micro). The pulp was removed using a modified protocol without the use of liquid nitrogen. Nucleic acid was found in 8 of the dental pulp, but in 7 of the blood samples. Sequencing of one of the samples showed the presence of genotype 1. Conclusions: A novel simplified methodology for the extraction and amplification of HCV nucleic acid was successful to detect the presence of persistent infections of the virus within the dental pulp tissue. The protocol may be helpful to detect past and ancient infections and to better understand the natural history of HCV.

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“…In Brazil, HCV prevalence in patients treated at health services in the Amazon was 16% (95%CI: 12.4-19.6) 14 . A study of HIV-infected individuals in the city of Santos showed a 36.2% co-infection rate (95%CI: 31.9-40.4), significantly higher among IDUs than non-IDUs (p < 0.001) 15 .…”

Section: Introductionmentioning

confidence: 99%

HCV and HIV infection and co-infection: injecting drug use and sexual behavior, AjUDE-Brasil I Project

et al. 2006

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Hepatite C: prevalência e fatores de risco entre portadores do VIH/SIDA em Belém, Pará, na Amazônia brasileira

Cited by 19 publications

References 37 publications

Co-Infection by Hepatitis C Virus in HIV-Infected Patients in Southern Brazil: Genotype Distribution and Clinical Correlates

Co-Infection by Hepatitis C Virus in HIV-Infected Patients in Southern Brazil: Genotype Distribution and Clinical Correlates

Detection of HCV Persistent Infections in the Dental Pulp: A Novel Approach for the Detection of Past and Ancient Infections

HCV and HIV infection and co-infection: injecting drug use and sexual behavior, AjUDE-Brasil I Project

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