Hepatic Veno-Occlusive Disease

Cefalo, Maria Giuseppina; Maurizi, Palma; Arlotta, A; Scalzone, Maria; Attinà, Giorgio; Ruggiero, Antonio; Riccardi, Riccardo

doi:10.2165/11531840-000000000-00000

Cited by 41 publications

(31 citation statements)

References 76 publications

(42 reference statements)

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“…More severe reactions and systemic anaphylaxis may be life-threatening (Cefalo et al, 2010). It is possible that carboplatin HSRs are not always recognized.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Some authors have tried to predict HSRs by using skin testing (Zanotti et al, 2001; Cefalo et al, 2010). Zanotti et al (2001) developed a skin-test protocol for adult patients with gynecological malignancies and first demonstrated that skin testing for carboplatin made it possible to identify patients at risk for HSRs with a 99% negative predictive value.…”

Section: Pathophysiologymentioning

confidence: 99%

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Hypersensitivity to Carboplatin in Children with Malignancy

et al. 2017

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Purpose: Carboplatin-based regimens have proven efficacy in children with cancer. However, the development of hypersensitivity reactions (HSRs) may have a negative impact on treatment intensity and patients’ outcome. The aim of this review is to summarize the incidence and the clinical features of HSRs occurring in children with cancer treated with carboplatin and their impact on treatment efficacy.Methods: Data were collected by searching for relevant studies on the incidence, clinical features and management of possible side effects about the use of carboplatin in children, published from March 1987 to October 2016 in the PubMed database.Results: Carboplatin HSRs present with mild/moderate to severe clinical patterns. The risk of HSR is related to the cumulative number of infusions. Moreover, a greater risk of developing an HSR has been observed in younger patients than in older age groups of children; risk is also greater in girls and in patients with a prior history of allergy to other drugs. Management options include cessation of carboplatin and switching to another agent, premedication with antihistamines and/or corticosteroids, and carboplatin desensitization. For sensitized patients who have obtained benefits from carboplatin, the continuation of the treatment is desirable and desensitization protocols have showed promising results.Conclusion: Clinicians must not underestimate the potential risk and occurrence of carboplatin HSRs in the pediatric population in order to outline adequate management strategies. Desensitization protocols should be considered for patients sensitive to carboplatin in order to avoid having to discontinue an effective chemotherapy.

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“…More severe reactions and systemic anaphylaxis may be life-threatening (Cefalo et al, 2010). It is possible that carboplatin HSRs are not always recognized.…”

Section: Clinical Featuresmentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

Hypersensitivity to Carboplatin in Children with Malignancy

et al. 2017

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“…It is reported more commonly with myeloablative chemotherapy and total body irradiation prior to allogeneic bone marrow transplantation (Cefalo et al 2010 ). HVOD is characterized by necrosis of the hepatocytes, sinusoidal fi brosis, and occlusion of the hepatic venules with subsequent hepatic congestion (Robinson et al 2011 ).…”

Section: 3mentioning

confidence: 99%

“…The clinical presentation includes jaundice, tender hepatomegaly, and unexplained weight gain with or without ascites. Liver enzymes may be abnormal and thrombocytopenia may develop (Cefalo et al 2010 ;Richardson and Guinan 1999 ).…”

Section: 3mentioning

confidence: 99%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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“…The underlying pathogenesis is complex and thought to involve toxic injury to sinusoidal endothelial cells 1. Histologic confirmation with liver biopsy is the gold standard for diagnosis; however, due to the procedural risk and invasive nature of a biopsy the majority of cases are diagnosed clinically.…”

mentioning

confidence: 99%

Hepatic Sinusoidal Obstruction Syndrome During Chemotherapy for Childhood Medulloblastoma

Kotecha

Buckland

Phillips

et al. 2014

Journal of Pediatric Hematology/Oncology

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Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease, is a well-recognized toxic complication after autologous and allogeneic hematopoietic stem cell transplant, during treatment of Wilms tumor and rhabdomyosarcoma associated with actinomycin-D, and during acute lymphoblastic leukemia therapy due to oral 6-thioguanine. However, its occurrence in the context of chemotherapy regimens for other childhood malignancies is rare. We report a 5-year-old girl with high-risk anaplastic medulloblastoma, who developed severe HSOS during her second cycle of maintenance chemotherapy, consisting of vincristine, cisplatin, and cyclophosphamide. She was treated with defibrotide with complete resolution of the HSOS. These findings and a review of the literature, highlight the occurrence of HSOS in children outside the established settings of hematopoietic stem cell transplantation, Wilms tumor, rhabdomyosarcoma, and acute lymphoblastic leukemia.

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Hepatic Veno-Occlusive Disease

Cited by 41 publications

References 76 publications

Hypersensitivity to Carboplatin in Children with Malignancy

Hypersensitivity to Carboplatin in Children with Malignancy

Female Pelvis: Genital Organs

Hepatic Sinusoidal Obstruction Syndrome During Chemotherapy for Childhood Medulloblastoma

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