“…Elevated serum ferritin has also been associated with increased risk of bacterial infection, 7,8 mucositis, 9 acute GvHD, 10 chronic liver disease, 11 and SOS. 12,24 However, because serum ferritin is an imperfect measure of total body iron, the exact prognostic role of iron overload in allo-HSCT remains to be determined. Several prospective studies and a multi-center meta-analysis examining the impact of elevated LIC on HSCT outcomes came to different conclusions regarding the prognostic relevance of LIC in HSCT, mainly due to the use of different LIC thresholds.…”