Hepatic triglyceride lipase in diabetic dogs

Muller, David L.; Saudek, Christopher D.; Applebaum-Bowden, Deborah

doi:10.1016/0026-0495(85)90008-3

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…cow, pig, cat and chicken) with confirmed reactivity. Furthermore, the results were similar to previously reported ranges for dogs (Muller et al, 1985; Watson et al, 1995). Despite this evidence to support the application to canine samples, validation of the assay is needed to confirm the findings of this study.…”

Section: Discussionsupporting

confidence: 92%

Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

Furrow

Jaeger

Parker

et al. 2016

The Veterinary Journal

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Spontaneous hyperlipidemia in rats causes glomerular disease. Idiopathic hypertriglyceridemia (HTG) is prevalent in Miniature schnauzers, but its relationship with proteinuria is unknown. Decreased activity of major lipid metabolism enzymes, lipoprotein lipase (LPL) and hepatic lipase (HL), may play a role in the cyclic relationship between hyperlipidemia and proteinuria. These enzymes have also not been previously investigated in Miniature shnauzers. The aims of this study were to determine the relationship between HTG and proteinuria in Miniature schnauzers and to measure LPL and HL activities in a subset of dogs. Fifty-seven Miniature schnauzers were recruited (34 with and 23 without HTG). Fasting serum triglyceride concentrations and urine protein-to-creatinine ratios (UPC) were measured in all dogs, and LPL and HL activities were determined in 17 dogs (8 with and 9 without HTG). There was a strong positive correlation between triglyceride concentration and UPC (r = 0.77–0.83, P < 0.001). Proteinuria (UPC ≥ 0.5) was present in 60% of dogs with HTG and absent from all dogs without HTG (P < 0.001). Proteinuric dogs were not azotemic or hypoalbuminemic. Dogs with HTG had a 65% reduction in LPL activity relative to dogs without HTG (P < 0.001); HL activity did not differ. Proteinuria occurs with HTG in Miniature schnauzers and could be due to lipid-induced glomerular injury. Reduced LPL activity may contribute to the severity of HTG, but further assay validation is required.

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Section: Discussionsupporting

confidence: 92%

Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

Furrow

Jaeger

Parker

et al. 2016

The Veterinary Journal

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The Pancreas and Lipoprotein Metabolism

Ginsberg

Goldberg

2001

Comprehensive Physiology

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The sections in this article are: Lipoproteins Lipoprotein Structure and Composition Plasma Lipid Enzymes Transport of Exogenous (Dietary) Lipids Transport of Endogenous Lipids Regulation of the Assembly and Secretion of Apoprotein B‐100‐Containing Lipoproteins Very‐Low‐Density Lipoprotein Catabolism Very‐Low‐Density Lipoprotein Metabolism in Diabetes Mellitus Low‐Density Lipoprotein Production and Catabolism Low‐Density Lipoprotein Metabolism in Diabetes Mellitus Metabolism of Apoprotein A‐I‐Containing Lipoproteins Apoprotein A‐I‐Containing Lipoproteins in Diabetes Mellitus

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