Hepatic Trauma

Cothren, Clay C.; Moore, Ernest E.

doi:10.1007/s00068-008-8029-5

Cited by 17 publications

(15 citation statements)

References 45 publications

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“…Liver is the most commonly injured organ in blunt abdominal trauma [2]. Management of liver trauma has witnessed a sea of change since the advent of CT scans and advances in critical-care monitoring.…”

Section: Discussionmentioning

confidence: 99%

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Massive Liver Trauma—Multidisciplinary Approach and Minimal Invasive Surgery can Salvage Patients

Thapar

Ghawat²,

Dalvi³

et al. 2012

Indian J Surg

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Management of massive liver trauma (grades IV-VI) is associated with high morbidity and mortality. It can pose serious challenges to treating physician and requires multimodality interventions. For a successful outcome, timing of intervention is crucial. We report a case of grade V hepatic injury treated successfully with angioembolization, laparoscopic lavage, and endoscopic stenting during a time period from admission to discharge on the 24th day. Angioembolization was performed at admission after resuscitation as CT scan showed active extravasation in the arterial phase. Laparoscopic lavage and drainage was performed on the fifth day as abdominal inflammatory response failed to respond to medical management. There was biliary component of abdominal fluid noticed during laparoscopy, which manifested by postoperative localized biliary fistula; hence endoscopic stenting of the bile duct was performed on the seventh day. The patient recovered well with timely minimal invasive approach and was fine at 1 year follow-up.

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Section: Discussionmentioning

confidence: 99%

“…Hepatic injury scale grades liver injuries from grades I to VI and has universally streamlined the management of liver trauma [3]. Grade I-III injuries constitute 80-90 % of all liver injuries and are successfully managed by nonoperative method [2,4]. Grade VI injuries are avulsion of vascular pedicle and are associated with mortality.…”

Section: Discussionmentioning

confidence: 99%

Massive Liver Trauma—Multidisciplinary Approach and Minimal Invasive Surgery can Salvage Patients

Thapar

Ghawat²,

Dalvi³

et al. 2012

Indian J Surg

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show abstract

“…Sudden force makes liver laceration. Liver injuries constitute 5% of all traumas, making it the most common abdominal injury [6]. Due to position of liver in abdominal cavity and its large size, it is prone to gunshot wounds and stab wounds [6].…”

Section: Physical Damagementioning

confidence: 99%

“…Liver injuries constitute 5% of all traumas, making it the most common abdominal injury [6]. Due to position of liver in abdominal cavity and its large size, it is prone to gunshot wounds and stab wounds [6]. Liver located under the diaphragm also makes it especially prone to shearing forces [4].…”

Section: Physical Damagementioning

confidence: 99%

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

Upadhyay¹

2017

J Cell Sci Ther

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Present review article explains various causes of acute liver diseases and their therapeutics. This article describes major reasons of hepatic pathophysiological conditions and diseases including hepatitis, cholestasis, alcoholic and non-alcoholic steatohepatitis, jaundice, liver cirrhosis, carcinogenesis and many others. This article emphasizes use of proliferating hepatocytes, hepatic oval cells, adult human liver mesenchymal stem/progenitor cells, induced pluripotent stem cells (iPSCs) and hematopoietic stem cells in cell transplantation for restoration of liver structure and function. It also justified the therapeutic role of cell secreted growth factors and dietary factors required during natural healing and regeneration liver after surgery or liver transplantation. It sketches out regulatory roles of signaling pathways, expression of cell cycle regulators, growth factors, cytokines, and role of different mitogens in induction of liver stem/progenitor cells (LSPCs) after organ/stem cell transplantation. This article suggests a need for development of new advanced biomaterials, methods, technologies and stem cells for development of targeted therapies to combat and cure liver related diseases and disorders. This article also advice people for avoiding excessive use of alcohol, drugs, fats, salt, high energy diets, and iron as all are responsible of liver cirrhosis, damage and failure.

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“…Any delay can mean death and ideal treatment requires optimal interdisciplinary cooperation. Other subjects of interest in this issue are the liver [5], pancreas [6] and spleen [7] as frequent sites of intraabdominal injury. Liver and spleen trauma are increasingly treated non-surgically; indications and criteria for such treatment have changed with increasing experience and undergone further development.…”

mentioning

confidence: 99%

Focus on Solid Organ Injury

Uranues¹

2008

Eur J Trauma Emerg Surg

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Hepatic Trauma

Cited by 17 publications

References 45 publications

Massive Liver Trauma—Multidisciplinary Approach and Minimal Invasive Surgery can Salvage Patients

Massive Liver Trauma—Multidisciplinary Approach and Minimal Invasive Surgery can Salvage Patients

Stem Cell Therapeutics of Acute Liver Diseases, Transplantation, and Regeneration

Focus on Solid Organ Injury

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