“…Numerous studies, designed to examine gene expression after AhR activation by an exogenous ligand, have repeatedly reported AhR-dependent transcriptional regulation of CYP1 genes associated with AhR's traditional role in the adaptive metabolism of xenobiotics (Nebert et al, 2004). More recently, microarray studies have proved to be paramount in identifying expression changes in TCDD-dependent gene batteries associated with the toxicities observed after AhR activation (Vezina et al, 2004;Boverhof et al, 2005;Hayes et al, 2007;Lo et al, 2011). AhR activation by exogenous ligands is associated with several toxicities affecting multiple tissues and biologic systems, including hepatotoxicity, cardiotoxicity, teratogenesis, endocrine disruption, and diabetes (Denison et al, 2011).…”