Hepatic Steatosis Index and Lipid Accumulation Product as middle-term predictors of incident metabolic syndrome in a large population sample: data from the Brisighella Heart Study

Cicero, Arrigo F G; D’Addato, Sergio; Reggi, Alessandra; Marchesini, Giulio; Borghi, Claudio

doi:10.1007/s11739-012-0875-9

Cited by 25 publications

(18 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…External validation is so far limited and the correlation with liver histology has not been studied. However, the HSI seems to predict incident metabolic syndrome . VAI is a marker of visceral adipose dysfunction (increased lipolysis, imbalanced adipocytokine production) associated with cardiovascular events and inversely correlated with insulin sensitivity .…”

Section: Discussionmentioning

confidence: 99%

Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease

Fedchuk

Nascimbeni

Pais

et al. 2014

Aliment Pharmacol Ther

361

296

View full text Add to dashboard Cite

Summary Background Several steatosis biomarkers are available with limited independent validation. Aim To determine diagnostic value and limitations of several steatosis biomarkers using liver biopsy as reference standard in a large cohort of patients with suspected NAFLD. Methods Three hundred and twenty‐four consecutive liver biopsies were included. Histological steatosis was categorised as none (<5%), mild (5–33%), moderate (33–66%) and severe (>66%). Five steatosis biomarkers were measured: fatty liver index (FLI), NAFLD liver fat score (NAFLD‐LFS), hepatic steatosis index (HSI), visceral adiposity index (VAI) and triglyceride × glucose (TyG) index. Results Steatosis grades prevalence was: none 5%, mild 39%, moderate 30% and severe 27%. Except for VAI, the steatosis biomarkers showed a linear trend across the steatosis grades. However, their correlation with the histological amount of steatosis was only weak‐moderate. All steatosis biomarkers had an adequate diagnostic accuracy for the presence of steatosis: AUROCs for FLI, LFS, HSI, VAI and TyG were 0.83, 0.80, 0.81, 0.92 and 0.90. However, their ability to quantify steatosis was poor: none of them distinguished between moderate and severe steatosis and the AUROCs for predicting steatosis >33% were 0.65, 0.72, 0.65, 0.59 and 0.59 for FLI, LFS, HSI, VAI and TyG. Both fibrosis and inflammation significantly confounded the association between steatosis biomarkers and steatosis. The steatosis biomarkers were all correlated with HOMA‐IR, independent from histological steatosis. Conclusions All five steatosis biomarkers can diagnose steatosis and are correlated with insulin resistance. They are confounded by fibrosis and inflammation, and do not accurately quantify steatosis; this may limit their clinical utility. More research is needed to identify truly independent and quantitative markers of steatosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease

Fedchuk

Nascimbeni

Pais

et al. 2014

Aliment Pharmacol Ther

361

296

View full text Add to dashboard Cite

show abstract

“…Plasma used was obtained by the addition of Na 2 EDTA (1 mg = ml) and centrifuged at 3,000 g for 15 min at 48 ° C. Immediately after centrifugation, plasma samples were frozen and stored at -80 ° C for 3 months maximum. The following parameters were evaluated using standardized methods: total cholesterol (TC) [21] , HDL-C [22] , triglycerides (TG) [23] , LDL-C [24] , glucose, creatinine, liver transaminases, and creatinin-phosfo-kinase (CPK) [25] . All measurements were centrally performed in the laboratory of our department.…”

Section: Assessmentsmentioning

confidence: 99%

Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects

et al. 2016

Self Cite

View full text Add to dashboard Cite

Aim: The aim of our study was to investigate whether treatment with red yeast rice added with Coenzyme Q10 is associated with changes in endothelial function and arterial stiffness. Methods: This double blind, placebo-controlled, randomized clinical trial was carried out on 40 non-smoker moderately hypercholesterolemic subjects (ClinicalTrial.gov ID NCT02492464). After 4 weeks of diet and physical activity, patients were allocated to treatment with placebo or with an active product containing 10 mg monacolins and 30 mg Coenzyme Q10, to be assumed for 6 months. Endothelial reactivity and arterial stiffness have been measured through the validated Vicorder® device. Results: During monacolin treatment, patients experienced a more favorable percentage change in low density lipoprotein (LDL)-cholesterol (after monacolin treatment: -26.3%; after placebo treatment: +3.4%, p < 0.05). Endothelial reactivity (pulse volume displacement after monacolin treatment: +6.0%; after placebo treatment: -0.3%, p < 0.05), and arterial stiffness (pulse wave velocity (PWV) after monacolin treatment: -4.7%; after placebo: +1.1%, p < 0.05) also significantly improved only after monacolin treatment. Conclusion: The long-term assumption of the tested dietary supplement is associated with an improvement in LDL-cholesterolemia, endothelial reactivity and PWV in moderately hypercholesterolemic subjects.

show abstract

“…Immediately after centrifugation, plasma samples were frozen and stored at−80°C for no more than 3 months. The following parameters were evaluated via standardized methods: total cholesterol (TC) [20], high-density lipoprotein-cholesterol (HDL-C) [21], triglycerides (TG) [22], LDL-C [23], apolipoprotein B (apoB) [24], apolipoprotein AI (apoAI) [25], glucose, creatinine, liver transaminases, and creatinin phosphokinase (CPK) [26]. All measurements were centrally performed in the laboratory of our department.…”

Section: Assessmentsmentioning

confidence: 99%

Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects

et al. 2013

Self Cite

View full text Add to dashboard Cite

Hepatic Steatosis Index and Lipid Accumulation Product as middle-term predictors of incident metabolic syndrome in a large population sample: data from the Brisighella Heart Study

Cited by 25 publications

References 5 publications

Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease

Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease

Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10 Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in Moderately Hypercholesterolemic Subjects

Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects

Contact Info

Product

Resources

About