Hepatic Steatosis in Genotype 4 Chronic Hepatitis C Is Mainly Because of Metabolic Factors

Tsochatzis, Emmanuel; Papatheodoridis, George V.; Manesis, Emanuel K.; Chrysanthos, N.; Kafiri, Georgia; Petraki, Kalliopi; Hadziyannis, Emilia; Pandelidaki, Helen; Zafiropoulou, Rodessa; Savvas, Savvas; Koskinas, John; Archimandritis, Athanasios

doi:10.1111/j.1572-0241.2006.01025.x

Cited by 38 publications

(32 citation statements)

References 29 publications

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“…This is comparable to findings from Tsochatzis et al [10] who found that moderate to severe steatosis was more frequent in genotypes 3 than 4, but was similar between genotypes 1 and 4. On the other hand, Reddy et al [11] found that steatosis was more prevalent in genotype 3 than other genotypes.…”

Section: Discussionsupporting

confidence: 94%

Prevalence and Impact of Hepatic Steatosis on the Response to Antiviral Therapy in Saudi Patients with Genotypes 1 and 4 Chronic Hepatitis C

et al. 2010

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Section: Discussionsupporting

confidence: 94%

Prevalence and Impact of Hepatic Steatosis on the Response to Antiviral Therapy in Saudi Patients with Genotypes 1 and 4 Chronic Hepatitis C

et al. 2010

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“…In this setting, IR is either virus-mediated or due to host metabolic factors such as visceral obesity [44] . A similar association has been shown for genotype 4 [45] . In contrast, steatosis in HCV genotype 3 infection is predominantly a direct effect of the virus, occurring in the absence of other metabolic risk factors [46,47] .…”

Section: Complications Of Hcv-induced Irsupporting

confidence: 66%

Molecular mechanisms of insulin resistance in chronic hepatitis C

Douglas

George²

2009

WJG

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It is now widely recognized that chronic hepatitis C (CHC) is associated with insulin resistance (IR) and type 2 diabetes, so can be considered a metabolic disease. IR is most strongly associated with hepatitis C virus (HCV) genotype 1, in contrast to hepatic steatosis, which is associated with genotype 3 infection. Apart from the well-described complications of diabetes, IR in CHC predicts faster progression to fibrosis and cirrhosis that may culminate in liver failure and hepatocellular carcinoma. More recently, it has been recognized that IR in CHC predicts a poor response to antiviral therapy. The molecular mechanisms for the association between IR and HCV infection are not well defined. This review will elaborate on the clinical associations between CHC and IR and summarize current knowledge regarding the molecular mechanisms that potentially mediate HCV-associated IR.

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“…The degree of steatosis in this genotype is independent of the HCV viral load, and antiviral therapy does not improve steatosis in these patients. Similar data have been obtained for genotype 4 infection, whereas few data are available for genotype 2 [263] . The presence of HCV infection in patients with DM may also increase the proportion of DM-related chronic nephrologic complications [86,264] .…”

supporting

confidence: 64%

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

Antonelli

Ferrari

Giuggioli

et al. 2014

WJD

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cytokines, chemokines, and other immune-mediated mechanisms. Few data have been reported on the association of CHC and T1DM and reports on the potential association between T1DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoimmunity and in certain cases lead to the development of T1DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with non-diabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effective programmes for the surveillance and treatment of diabetic CHC patients. AbstractHepatitis C virus (HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus (T1DM) and T2DM. T2DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2DM and chronic hepatitis C (CHC) infection. The processes through which CHC is associated with T2DM seem to involve direct viral effects, insulin resistance, proinflammatory Submit a

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Hepatic Steatosis in Genotype 4 Chronic Hepatitis C Is Mainly Because of Metabolic Factors

Cited by 38 publications

References 29 publications

Prevalence and Impact of Hepatic Steatosis on the Response to Antiviral Therapy in Saudi Patients with Genotypes 1 and 4 Chronic Hepatitis C

Prevalence and Impact of Hepatic Steatosis on the Response to Antiviral Therapy in Saudi Patients with Genotypes 1 and 4 Chronic Hepatitis C

Molecular mechanisms of insulin resistance in chronic hepatitis C

Hepatitis C virus infection and type 1 and type 2 diabetes mellitus

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