Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C

Tsochatzis, Emmanuel; Papatheodoridis, George V.; Manesis, Emanuel K.; Chrysanthos, N.; Kafiri, Georgia; Archimandritis, Athanasios

doi:10.1016/j.dld.2007.07.151

Cited by 47 publications

(58 citation statements)

References 29 publications

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“…This finding is in agreement with previously reported literature 21 . Moreover , the severity of HS was not associated with the severity of fibrosis, which is in agreement with ɣ earlier reports 9,22 . The primary determinant of HS in the present study was HOMA-IR.…”

Section: Discussionsupporting

confidence: 82%

Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis

Yılmaz¹,

Köklü²,

Büyükbayram³

et al. 2015

Afr H. Sci.

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Background: The effect of hepatitis B virus (HBV) infection on fatty liver disease is unclear.. Objectives: The aim of this study was to investigate the viral and host causes of fatty liver in chronic hepatitis B (CHB) patients. This study included 88 CHB patients of which 17 were not treated. Liver biopsy was performed in each patient. Group 1 included those with hepatic steatosis (n=28) and group 2 those without hepatic steatosis. The groups were compared in terms of age, body mass index (BMI), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), viral load, biochemical parameters and histological findings. Patients in group 1 were subdivided according to the degree of steatosis as follows: grade 1 (15 patients, 53.6%), grade 2 (6 patients, 21.4%),and grade 3 (7 patients, 25%). Results: In group 1 (n=28), mean age, BMI, cholesterol, and HOMA-IR were found to be significantly higher than in group 2 (n=60). There were no significant differences in the positivity of viral load, HbeAg, treatment, fibrosis and other laboratory parameters between the two groups. HOMA-IR was the only independent predictive factor of liver steatosis in patients with CHB in logistic regression analysis. Conclusion: Hepatic steatosis in CHB patients was associated with host metabolic factors.

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Section: Discussionsupporting

confidence: 82%

Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis

Yılmaz¹,

Köklü²,

Büyükbayram³

et al. 2015

Afr H. Sci.

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“…Thus the liver becomes more adipogenic sequestering most of the lipids that diffuse into it. This scenario creates a steatotic condition in the infected liver as have been reported by some researchers (Altiparmak et al 2005;Thormopuolos et al, 2006;Tsochatzis et al 2007;and Cindoruk et al, 2007). This may account in part for the observed decreased circulating triglyceride in serum of the hepatitis B infected population in relation to the healthy control.…”

Section: Discussionmentioning

confidence: 56%

Lowered Serum Triglyceride Levels among Chronic Hepatitis B-Infected Patients in Ghana

Kwarteng¹,

Owusu²,

Afihene³

et al. 2013

Jnl Sci Tech

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Dyslipidemia is a common finding in most studies of liver diseases. Little is however known about the effect of the two pathological stages of chronic hepatitis B (CHB) infection -chronicsymptomatic and asymptomatic -on the distribution of serum lipids in CHB infection. We conducted a study on CHB-infected patients attending specialist care at the Gastro-Intestinal (GI) Clinic at the Komfo Anokye Teaching Hospital (KATH) during a 7-month period. 64 participants were randomly sampled over the period. On the basis of serological and liver enzyme assays, participants were categorised as chronic asymptomatic, chronic symptomatic and healthy individuals. The relationship between the hosts pathological stage of infection were evaluated with the indices of lipid metabolism -LDL, HDL, triglyceride, and total serum cholesterol using ANOVA. The 64 volunteers recruited in the study were found to consist of 18 patients (28.1%) who were chronic symptomatic, 35 patients (54.7%) who were chronic asymptomatic hepatitis B, and 11 (17.2%) were healthy subjects. Significant overall male dominance was observed among all categories of population enrolled (p=0.0063). Serum triglyceride levels decreased more among the CHB-infected population compared to the healthy individuals (p=0.0010) with value lowest among the chronic symptomatic population. Basal serum cholesterol, HDL, and LDL were unaffected by the disease. This work reveals that serum triglyceride is significantly lowered in CHB infection and that the extent of this decrease in host is independent of the pathological stage of the infection.

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“…However, according to the current reports [7,8,11,17,18,[103][104][105][106][107][108][109][110], the prevalence of NAFLD in CHB ranges widely from 13.6 to 59.3 % ( Table 1). The significant divergence may be due to the differences in ethnicity, demography, and the precise criterion in the studies.…”

Section: Clinical Study Prevalence and Causative Analysis Of Steatosimentioning

confidence: 85%

Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact

et al. 2015

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Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The present article reviewed the recent studies aiming to explore the relationship between CHB and NAFLD from different aspects, including the relevant pathogenesis of CHB and NAFLD, the intracellular molecular mechanisms overlaying HBV infection and hepatic steatosis, and the observational studies with animal models and clinical cohorts for analyzing the coincidence of the two diseases. It is concluded that although numerous cross-links have been suggested between the molecular pathways in HBV infection and NAFLD pathogenesis, regarding whether HBV infection can substantially interfere with the occurrence of NAFLD or vice versa in the patients, there is still far from a conclusive agreement.

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Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: A comparative approach with genotype 1 chronic hepatitis C

Cited by 47 publications

References 29 publications

Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis

Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis

Lowered Serum Triglyceride Levels among Chronic Hepatitis B-Infected Patients in Ghana

Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact

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