Hepatic small vessel neoplasm – A systematic review

Anastomosing hemangioma of the liver: An unusual variant in abdominal MRI imaging

“…Classic biopsy shows non-proliferative capillary vascular channels, hobnailing of endothelial cells, fibrin thrombi, and hyaline eosinophilic globules [8 , 9] . Presence of GNAQ, Ki-67 index < 10% and lack of cytologic atypia and mitosis can help differentiate anastomosing hemangioma from malignant angiosarcomas [10 , 11] . Anastomosing hemangioma can also mimic another benign lesion known as hepatic small vessel neoplasm (HSVN) [11 , 12] .…”

Incidental Vascular Lesion in Explanted Liver: A Rare Case Report and Review of the Literature

“…Since 2016 when HSVN was first described [ 1 ], more than 25 cases have been published in the literature [ 2 , 3 ]. This lesion is asymptomatic and usually is an incidental finding.…”

“…The average size of HSVN is 2 cm 2 , and the size range is between 1 cm and 15.9 cm as reported by Walcott-Sapp et al [ 4 ]. In all known instances, the nodule presented in a background of liver disease [ 2 ].…”

Hepatic Small Vessel Neoplasm Mimics Prostate Cancer on 18F-DCFPyl PET/CT

“…[2][3][4] Originally considered to be tumors of uncertain biologic potential, longer-term outcome data have shown that HSVNs follow a benign clinical course. 5 Thus, it is important to distinguish HSVN from angiosarcoma, an aggressive malignancy that shows infiltrative growth, nuclear atypia, and an increased Ki-67 proliferation index. Molecular genetic studies have found that HSVNs harbor GNAQ or GNA14 point mutations, similar to other benign vascular tumors.…”

“…Hepatic small vessel neoplasm is a recently described rare vascular tumor type, 2 characterized by small vascular channels lined by a monolayer of bland endothelial cells that show infiltrative growth into surrounding tissue 2–4 . Originally considered to be tumors of uncertain biologic potential, longer-term outcome data have shown that HSVNs follow a benign clinical course 5 . Thus, it is important to distinguish HSVN from angiosarcoma, an aggressive malignancy that shows infiltrative growth, nuclear atypia, and an increased Ki-67 proliferation index.…”