Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease

Rein-Fischboeck, Lisa; Krautbauer, Sabrina; Eisinger, Kristina; Pohl, Rebekka; Meier, Elisabeth M.; Weiss, Thomas S.; Buechler, Christa

doi:10.1016/j.bbrc.2015.09.149

Cited by 12 publications

(10 citation statements)

References 42 publications

(52 reference statements)

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“…Median chemerin was 106·9 (57·8–480·8) in the liver of those 9 patients compared to 1·8 (0·34–9·0) in the 109 patients with comparable expression ( P < 0·001). Analysis of further genes did not reveal abnormal expression levels in these samples. Nevertheless, these patients were excluded from further analysis.…”

Section: Methodsmentioning

confidence: 71%

Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis

Pohl

Haberl

Rein-Fischboeck

et al. 2016

Eur J Clin Investigation

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Section: Methodsmentioning

confidence: 71%

Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis

Pohl

Haberl

Rein-Fischboeck

et al. 2016

Eur J Clin Investigation

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“…These samples have been introduced in a recent study [26]. Details of the histological scoring which was done as described [27] are summarized in Table 2.…”

Section: Methodsmentioning

confidence: 99%

Chemokine-Like Receptor 1 mRNA Weakly Correlates with Non-Alcoholic Steatohepatitis Score in Male but Not Female Individuals

Neumann

Meier

Rein-Fischboeck

et al. 2016

IJMS

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The chemokine-like receptor 1 (CMKLR1) ligands resolvin E1 and chemerin are known to modulate inflammatory response. The progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) is associated with inflammation. Here it was analyzed whether hepatic CMKLR1 expression is related to histological features of NASH. Therefore, CMKLR1 mRNA was quantified in liver tissue of 33 patients without NAFLD, 47 patients with borderline NASH and 38 patients with NASH. Hepatic CMKLR1 mRNA was not associated with gender and body mass index (BMI) in the controls and the whole study group. CMKLR1 expression was similar in controls and in patients with borderline NASH and NASH. In male patients weak positive correlations with inflammation, fibrosis and NASH score were identified. In females CMKLR1 was not associated with features of NAFLD. Liver CMKLR1 mRNA tended to be higher in type 2 diabetes patients of both genders and in hypercholesterolemic women. In summary, this study shows that hepatic CMKLR1 mRNA is weakly associated with features of NASH in male patients only.

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“…We examined three SNPs (rs10846744, rs5888, and rs3782287) of the SCARB1 gene known to be associated with human diseases1316171819. However, only the rs10846744 variant was identified as a predictor of virological response in CHC patients receiving treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Three SNPs (rs10846744, rs5888, and rs3782287) of the SCARB1 gene with an allele minor frequency of >1% and have been linked to humans diseases were investigated1316171819.…”

Section: Methodsmentioning

confidence: 99%

“…Among these entry factors, the scavenger receptor class B type I (SR-BI) protein, which is highly expressed on hepatocytes, encoded by the SCARB1 gene, and a receptor for high density lipoproteins (HDL), very-low-density lipoproteins (VLDL) and oxidized forms of LDL9, may interact with virus-associated lipoproteins to help the attachment and binding of HCV particles10. Of note, several studies have reported the associations of SCARB1 single nucleotide polymorphisms (SNPs) with serum HDL, LDL levels1112131415, and various human diseases16171819. However, although SR-BI protein plays an essential role in HCV infection, the impact of SCARB1 gene SNPs on HCV infection remain largely unknown.…”

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confidence: 99%

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Association of SCARB1 Gene Polymorphisms with Virological Response in Chronic Hepatitis C Patients Receiving Pegylated Interferon plus Ribavirin Therapy

Hsu

Liu

et al. 2016

Sci Rep

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The scavenger receptor type B class I(SR-BI) is a receptor for high-density lipoproteins(HDL) and one of entry factors for hepatitis C virus(HCV). We examined the association of single nucleotide polymorphisms(SNPs) of the SCARB1 gene, which encodes SR-BI, with virologic responses to pegylated interferon-based treatment in Asian chronic hepatitis C(CHC) patients. Human genomic and clinical data were collected from 156 consecutive Taiwanese HCV genotype 1 or 2 patients who received pegylated interferon plus ribavirin therapy and 153 non-HCV healthy subjects. Three SNPs(rs10846744, rs5888, and rs3782287) of the SCARB1 gene that have been linked to humans diseases were investigated. rs10846744 rather than rs5888 or rs3782287 was associated with serum HCV RNA level and sustained virologic response(SVR) to pegylated interferon plus ribavirin therapy in CHC patients(GG vs. non-GG genotype, Adjusted Odds Ratio, 95% CI: 0.32, 0.11–0.95, P = 0.039). Among patients with IL28B rs8099917 non-TT genotypes, those with rs10846744 non-GG genotype had a higher SVR rate than those with GG genotypes. In addition, patients with GG genotype had a higher fasting blood glucose level than those with CC genotype. In conclusion, SCARB1 gene polymorphisms may serve as a potential predictor of treatment responses in CHC patients receiving interferon-based therapy. (ClinicalTrials.gov number, NCT02714712).

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Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease

Cited by 12 publications

References 42 publications

Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis

Hepatic chemerin mRNA expression is reduced in human nonalcoholic steatohepatitis

Chemokine-Like Receptor 1 mRNA Weakly Correlates with Non-Alcoholic Steatohepatitis Score in Male but Not Female Individuals

Association of SCARB1 Gene Polymorphisms with Virological Response in Chronic Hepatitis C Patients Receiving Pegylated Interferon plus Ribavirin Therapy

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