Hepatic sarcoidosis

Isolated hepatic sarcoidosis

“…Ascites occurs as transudate (portal hypertension, deterioration of right heart function) or exudate (peritoneal infiltration with sarcoid nodules) 17 . Rare clinical presentation of liver sarcoidosis are jaundice and Budd-Chiari syndrome 18 . Jaundice occurs as a result of direct affection of the biliary system (intrahepatic cholestasis, "vanishing" bile duct and ductopenia) 18 .…”

“…Rare clinical presentation of liver sarcoidosis are jaundice and Budd-Chiari syndrome 18 . Jaundice occurs as a result of direct affection of the biliary system (intrahepatic cholestasis, "vanishing" bile duct and ductopenia) 18 . If hepatic granulomas or enlarged lymph nodules compress the main biliary ducts, it may develop jaundice which corresponds to the differential diagnosis of cholangiocelular carcinoima 6,[19][20][21] .…”

“…If hepatic granulomas or enlarged lymph nodules compress the main biliary ducts, it may develop jaundice which corresponds to the differential diagnosis of cholangiocelular carcinoima 6,[19][20][21] . Budd-Chiari sindrome is caused by compromited hepatic veins blood flow and consequent development of thrombosis 18 . Blood analysis in patients with sarcoidosis can show leucopenia, lymphopenia, eosinophilia and monocytosis.…”

“…ACE is elevated in around 70% of patients with hepatic sarcoidosis 6 . Elevation of alkaline phosphatase and -glutamyl transferase is found in 20-40% of patients 6,10,18,22 . Transaminases may be normal or slightly elevated.…”

Liver-test abnormalities in sarcoidosis

“…Only 5-30% of the patients present with atypical clinical signs and symptoms such as nausea, vomiting, abdominal pain in the right upper quadrant, a painful liver during palpation and/or hepatomegaly [3,8,[10][11][12][14][15][16][17][18][19][20][21]. In a minority of patients, hepatic sarcoidosis can be a serious and rapid progressive disease with the occurrence of complications as cirrhosis, portal hypertension, chronic cholestasis and Budd-Chiari syndrome [3,4,8,10,13,14,17,[21][22][23][24]. Because symptomatic hepatic sarcoidosis is uncommon, studies to investigate the natural history and the diagnostic approach are scarce.…”