Hepatic resection versus transarterial chemoembolization in infiltrative hepatocellular carcinoma: A multicenter study

Wang, Yuanqi; Shen, Jingxian; Feng, Shi‐Ting; Liu, Ruiming; Lai, Jiaming; Li, Dongming; Peng, Baogang; Wang, Zaiguo; Huang, Cheng

doi:10.1111/jgh.15060

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…This finding agreed with previous studies, supporting the advancement of patients with PS1 alone to an advanced stage in the BCLC staging system ( 14 , 25 ). However, some studies have reported contrasting conclusions ( 26 , 27 ). In the HKLC staging system, PS0 and PS1 are equivalent and should be assigned to the same treatments ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

Potential candidates for liver resection in liver-confined advanced HCC: a Chinese multicenter observational study

Bai,

Wang,

Zhao

et al. 2023

Front. Oncol.

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BackgroundAdvanced hepatocellular carcinoma (HCC) is characterized as symptomatic tumors [performance status (PS) score of 1-2], vascular invasion and extrahepatic spread, but patients with PS1 alone may be eliminated from this stage. Although liver resection is used for liver-confined HCC, its role in patients with PS1 alone remains controversial. Therefore, we aimed to explore its application in such patients and identify potential candidates.MethodsEligible liver-confined HCC patients undergoing liver resection were retrospectively screened in 15 Chinese tertiary hospitals, with limited tumor burden, liver function and PS scores. Cox-regression survival analysis was used to investigate the prognostic factors and develop a risk-scoring system, according to which patients were substratified using fitting curves and the predictive values of PS were explored in each stratification.ResultsFrom January 2010 to October 2021, 1535 consecutive patients were selected. In the whole cohort, PS, AFP, tumor size and albumin were correlated with survival (adjusted P<0.05), based on which risk scores of every patient were calculated and ranged from 0 to 18. Fitting curve analysis demonstrated that the prognostic abilities of PS varied with risk scores and that the patients should be divided into three risk stratifications. Importantly, in the low-risk stratification, PS lost its prognostic value, and patients with PS1 alone achieved a satisfactory 5-year survival rate of 78.0%, which was comparable with that PS0 patients (84.6%).ConclusionSelected patients with PS1 alone and an ideal baseline condition may benefit from liver resection and may migrate forward to BCLC stage A.

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Section: Discussionmentioning

confidence: 99%

Potential candidates for liver resection in liver-confined advanced HCC: a Chinese multicenter observational study

Bai,

Wang,

Zhao

et al. 2023

Front. Oncol.

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“…Conventional treatments include hepatic resection, liver transplantation, local ablation with radiofrequency, and hepatic artery intervention, such as transarterial chemoembolisation etc,. [ 3 , 4 , 5 ]. Currently, systemic therapies including tyrosine kinase inhibitor, immune checkpoint inhibitors,a and monoclonal antibodies have challenged the use of conventional therapies in the treatment of liver cancer [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Single‐cell RNA‐seq and bulk RNA‐seq explore the prognostic value of exhausted T cells in hepatocellular carcinoma

Tang

Miao

Yang

et al. 2023

IET Systems Biology

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Hepatocellular carcinoma (HCC) remains a worldwide health problem. Mounting evidence indicates that exhausted T cells play a critical role in the progress and treatment of HCC. Therefore, a detailed characterisation of exhausted T cells and their clinical significance warrants further investigation in HCC. Based on the GSE146115, we presented a comprehensive single‐cell Atlas in HCC. Pseudo‐time analysis revealed that tumour heterogeneity progressively increased, and the exhausted T cells gradually appeared during tumour progression. Functional enrichment analysis revealed that the evolutionary process of exhausted T cells mainly contained the pathway of cadherin binding, proteasome, cell cycle, and T cell receptor regulation of apoptosis. In the International Cancer Genome Consortium database, we divided patients into three clusters with the T cell evolution‐associated genes. We found that the exhausted T cells are significantly related to poor outcomes through immunity and survival analysis. In The Cancer Genome Atlas database, the authors enrolled weighted gene co‐expression network analysis, univariate Cox analysis, and Lasso Cox analysis, then screened the 19 core genes in T cells evolution and built a robust prognostic model. This study offers a fresh view on evaluating the patients' outcomes from an exhausted T cells perspective and might help clinicians develop therapeutic systems.

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“…The prevalence and mortality of this malignancy have increased globally and are particularly high in North African and Asian nations (1). Currently, treatments include surgery, transcatheter arterial chemoembolization, liver transplant, radiotherapy, and biotherapy (2,3). Unlike other malignancies, liver cancer is frequently discovered only when it has progressed to the point that liver transplant, surgical treatments, and resection are no longer feasible (4).…”

Section: Introductionmentioning

confidence: 99%

β‑adrenergic receptor activation promotes the proliferation of HepG2 cells via the ERK1/2/CREB pathways

Lin,

He,

Liu

et al. 2023

Oncol Lett

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Primary liver cancer is one of the most frequently diagnosed malignant tumors seen in clinics, and typically exhibits aggressive invasive behaviors, a poor prognosis, and is associated with high mortality rates. Long-term stress exposure causes norepinephrine (NE) release and activates the β-Adrenergic receptor (β-AR), which in turn exacerbates the occurrence and development of different types of cancers; however, the molecular mechanisms of β-AR in liver cancer are not fully understood. In the present study, reverse transcription (RT)-PCR and RT-quantitative PCR showed that β-AR expression was upregulated in human liver cancer cells (HepG2) compared with normal liver cells (LO2). Moreover, NE treatment promoted the growth of HepG2 cells, which could be blocked by propranolol, a β-AR antagonist. Notably, NE had no significant effect on the migration and epithelial-mesenchymal transition in HepG2 cells. Further experiments revealed that NE increased the phosphorylation levels of the extracellular signal-regulated kinase 1/2 (ERK1/2) and cyclic adenosine monophosphate response element-binding protein (CREB), while inhibition of ERK1/2 and CREB activation significantly blocked NE-induced cell proliferation. In summary, the findings of the present study suggested that β-adrenergic receptor activation promoted the proliferation of HepG2 cells through ERK1/2/CREB signaling pathways.

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Hepatic resection versus transarterial chemoembolization in infiltrative hepatocellular carcinoma: A multicenter study

Cited by 4 publications

References 42 publications

Potential candidates for liver resection in liver-confined advanced HCC: a Chinese multicenter observational study

Potential candidates for liver resection in liver-confined advanced HCC: a Chinese multicenter observational study

Single‐cell RNA‐seq and bulk RNA‐seq explore the prognostic value of exhausted T cells in hepatocellular carcinoma

β‑adrenergic receptor activation promotes the proliferation of HepG2 cells via the ERK1/2/CREB pathways

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