Hepatic regeneration in a rat model is impaired by chemotherapy agents used in metastatic colorectal cancer

Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure

“…Rodent models using monocrotalin or oxaliplatin to induce SOS revealed impairment of liver regeneration and induction of liver injury following partial hepatectomy [35]. This was accompanied by less pronounced induction of hepatic mitogens, reduced liver volume recovery, enhanced hepatocellular necrosis and higher serum ALT and bilirubin levels [35,36].…”

Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases

“…Mechanisms underlying the negative influence of severe SD on major morbidity are unknown, although preoperative hepatic dysfunction, impairment of liver regeneration, Kupffer cell dysfunction, enhanced blood loss due to haemorrhagic pools, fragility of the liver, and increased hepatocellular necrosis as seen in human and animal models, can all be reasons for poor liver function and an increased complication rate after severe SD. However, as the P value was of borderline significance, the effect of severe SD on major morbidity must be interpreted with caution.…”

A Critical Analysis of Experimental Animal Models of Sinusoidal Obstruction Syndrome

“…Unfortunately, however, the FOLFOX-based model has faced limited reproducibility. In a study by Hubert et al (2015), which used oxaliplatin therapy in rats, the authors failed to induce sinusoidal damage after rats underwent 70% partial hepatectomy. 59 Similarly, in a comment published by Lentschener et al, the authors stated that they were unable to reproduce SOS in mice, even after nearly mirroring the methodology of Robinson et al (2013).…”

“…In a study by Hubert et al (2015), which used oxaliplatin therapy in rats, the authors failed to induce sinusoidal damage after rats underwent 70% partial hepatectomy. 59 Similarly, in a comment published by Lentschener et al, the authors stated that they were unable to reproduce SOS in mice, even after nearly mirroring the methodology of Robinson et al (2013). 60 In a response, Robinson et al attributed these findings to potential differences in diet, substrain of mice used, or even the drug source.…”