“…This variability in response is understandable when the individual pathways are considered, because the total secretion rate after 24 h of carbohydrate hyperalimentation/hyperinsulinemia was a function of two opposing trends (Tables IV and V). The decreased secretion of preformed FA, coupled with an increase in de novo synthesis, could explain the conflicting results obtained in previous studies in which acute hyperinsulinemia either decreased (12,15,(50)(51)(52)(53) or did not affect (11, 54) VLDL secretion. Depending on the experimental factors, such as the selection of subjects, whether or not they were fasted, and in particular the duration and extent of hyperinsulinemia, the effect on one pathway may predominate.…”