Hepatic porphyria in the fowl: A new disease?

Siller, W. G.; Wells, John W.

doi:10.1002/path.1710970216

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…This fact was consistent with previous reports [4,6,17,18]. But in human and bovine protoporphyria, hepatic lesions are not a main symptom, photosensitization is.…”

Section: Shiff (Pas)supporting

confidence: 93%

“…There was one chicken that had pigments in the lungs in a previous report [18]. To our knowledge, deposition of PP in the lungs, has not been described in humans and bovine.…”

Section: Shiff (Pas)mentioning

confidence: 75%

“…In previous reports also, all of the six chickens checked for sex were female to date [4,17,18]. It is thought that this disorder tends to affect females.…”

Section: Shiff (Pas)mentioning

confidence: 91%

“…Experimentally, it is induced in mice and pigs by drugs [5,14]. In birds, accumulation of protoporphyrin (PP) in the liver has been reported previously [4,6,17,18], but these reports have only described a small number of broiler chickens. This report describes the pathological and biochemical outline of the protoporphyric disorder based on many affected chickens.…”

mentioning

confidence: 99%

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Distribution of Protoporphyrin in Female Broiler Chickens Affected with Protoporphyria

Ueda

Aohagi

2005

The Journal of Veterinary Medical Science

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ABSTRACT. One hundred thirty-seven broiler chickens at a poultry meat processing plant had dark green to black livers. Thirty-one chickens of these were collected at random and examined pathologically and biochemically. All of thirty-one chickens were female. The chickens showed mild retarded growth and a remarkable atrophy of the gallbladders. Microscopically, the livers showed dark brown pigments in the Kupffer cells, hepatocytes, and portal triads. These pigments showed birefringence with a Maltese-cross pattern under polarized light. Hyperplasia of the cholangioles, fibrosis, and infiltration of inflammatory cells were present in the portal triads. All the examined samples showed the same dark brown pigments in alveolar walls of the lungs. A high concentration of protoporphyrin was detected in affected livers, marrow, and feces (489, 104, and 116 µg/g wet wt., respectively) by biochemical assay.KEY WORDS: chicken, liver, protoporphyrin.

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“…This fact was consistent with previous reports [4,6,17,18]. But in human and bovine protoporphyria, hepatic lesions are not a main symptom, photosensitization is.…”

Section: Shiff (Pas)supporting

confidence: 93%

“…There was one chicken that had pigments in the lungs in a previous report [18]. To our knowledge, deposition of PP in the lungs, has not been described in humans and bovine.…”

Section: Shiff (Pas)mentioning

confidence: 75%

“…In previous reports also, all of the six chickens checked for sex were female to date [4,17,18]. It is thought that this disorder tends to affect females.…”

Section: Shiff (Pas)mentioning

confidence: 91%

mentioning

confidence: 99%

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Distribution of Protoporphyrin in Female Broiler Chickens Affected with Protoporphyria

Ueda

Aohagi

2005

The Journal of Veterinary Medical Science

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“…By analogy with the bile pigments it was at first assumed that this green colouration was derived by degradation of a haem pigment, such as haemoglobin or myoglobin, during the development of the myopathy. The resistance to ethyl acetate-acetic acid mixture, which extracts haem pigments and porphyrins (Siller and Wells, 1969) and to other acidic solvents, shows that the pigment is covalently bound to protein. The disappearance of the colour as the result of acidic or enzymic digestion of the muscle supports this hypothesis but may also indicate that amino groups of the protein are involved in the structure of the pigment.…”

Section: Pigment Identificationmentioning

confidence: 99%