Hepatic parenchymal enhancement at Gd-EOB-DTPA-enhanced MR imaging: correlation with morphological grading of severity in cirrhosis and chronic hepatitis

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

“…94 For example, because the liver enhancement ratio can, with some correction, be correlated with degree ofˆbrosis, this technique has been used to determine stage of liverˆbrosis. [95][96][97] The ratio of hepatocyte phase enhancement has also been used to assess local hepatic function. 98 Thus, non-morphological or quantitative MR imaging using gadoxetic acid as well as quantitative assessment using diŠusion-weighted and perfusion imaging may represent the new generation of projects.…”

Hepatic parenchymal enhancement at Gd-EOB-DTPA-enhanced MR imaging: correlation with morphological grading of severity in cirrhosis chronic hepatitis

“…In addition, with such an approximate calculation, Qmax becomes strongly dependent on kPCr and/or [PCr] measured at rest. In their study, Khushu et al [1] reported no significant difference in the resting [PCr] values between hypothyroid patients and controls (43.6±0.8 vs. 42.0 ±1.0 mmol kg − 1 , respectively). Given that the resting [PCr] values were similar, the corresponding calculated Qmax…”

“…This point may explain high enhancement in cirrhotic livers. We have read with much interest the paper recently published by Khushu et al regarding the impaired muscle metabolism in hypothyroid patients [1]. Although the results of this investigation are of potential interest, we are actually concerned about the utilization of the phosphocreatine recovery rate constant (kPCr) as a simple index of mitochondrial function and the corresponding conclusions regarding the impact of hypothyroidism on muscle metabolism during exercise.…”

“…I have read with great interest a recent article published in your journal by Kanki et al [1] entitled "Hepatic parenchymal enhancement at gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging MR imaging: correlation with morphological grading of severity in cirrhosis and chronic hepatitis." As observed by the authors, no correlation was found between the severity of chronic hepatitis or cirrhosis and the parenchymal enhancement in the hepatobiliary phase of magnetic resonance (MR) imaging with Gd-EOB-DTPA.…”

“…In the Khushu et al study, cytosolic pH was found to be significantly lower after a 6-min constant-load plantar flexion exercise in hypothyroid patients compared to controls (6.95 ±0.02 vs. 7.02±0.06, respectively). Therefore, the conclusions of an altered mitochondrial function in hypothyroid patients [1] on the single basis of kPCr measurements have to be interpreted cautiously. Of note, several kinetic parameters are commonly used to describe PCr changes during exerciseto-recovery transition, including kPCr, the initial rate of PCr recovery (ViPCr) and the maximum aerobic capacity (Qmax) [4].…”