Hepatic nodule: a case of primary myelofibrosis

Cardoso, Filipe S.; Pires, João Veríssimo; Miranda, José Simão; Araújo, João Mascarenhas

doi:10.1136/bcr.05.2011.4220

Cited by 6 publications

(2 citation statements)

References 10 publications

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“…OPV involves variable obliteration of the portal vein, particularly in the terminal branches of the intrahepatic portal vein, and has been observed in patients with MPNs [3]. Finally, EMH can manifest as a focal hepatic nodule [6], diffuse hepatomegaly and portal hypertension [7], or laboratory manifestations as in the first, second, and fourth cases described in the current series [8].…”

Section: Discussionmentioning

confidence: 90%

The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib

Tremblay

Putra

Vogel

et al. 2019

Case Reports in Hematology

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Ruxolitinib is increasingly being utilized for the treatment of myelofibrosis and polycythemia vera, but the potential for hepatic toxicity is poorly understood. We performed a retrospective review of hepatic damage occurring in patients with myeloproliferative neoplasms receiving ruxolitinib. Relevant histologic images of liver biopsies were reviewed by an experienced liver pathologist and reported to a multidisciplinary team including hepatology and hematology. A variety of liver pathology was observed including extramedullary hematopoiesis, obliterative portal venopathy, and drug-induced liver injury. In all cases reviewed, the liver biopsy had significant treatment implications. We conclude that hepatology referral and liver biopsy in patients receiving ruxolitinib therapy with biochemical evidence of liver injury reveals a variety of etiologies which have significant treatment impact. Clinicians should be aware of the potential causes of liver damage in this population and initiate prompt referral and liver biopsy.

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Section: Discussionmentioning

confidence: 90%

The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib

Tremblay

Putra

Vogel

et al. 2019

Case Reports in Hematology

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“…All of these cases were misdiagnosed, and IEMH was not considered in the preoperative imaging diagnosis and differentiation. The most common imaging modalities used were CT and ultrasound[ 3 - 7 ]. There is a paucity of literature on the role of MRI, which might be due to the limitations of imaging technology at that time.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging features of intrahepatic extramedullary hematopoiesis: Three case reports

Luo¹,

Chen²,

Xie³

2022

WJCC

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BACKGROUND Extramedullary hematopoiesis rarely occurs within the liver alone, and is easily misdiagnosed. The radiological literature on this disease is exclusively case reports. There is a paucity of literature on the role of magnetic resonance imaging (MRI). The most common imaging modalities used are computed tomography and ultrasound. This report aims to provide more data on the appearance of extramedullary hematopoiesis using MRI to help radiologists establish the diagnosis. CASE SUMMARY Three patients (one male and two females) were incidentally found to have a hepatic mass or nodule, without hepatomegaly or splenomegaly. Laboratory tests including liver function, serum hepatic tumor markers, and hepatitis serologic markers were normal. On MRI scans, all lesions showed lower signal intensity on in-phase images than on out-phase images. One case showed changes in signal intensity on T2 weighted images (WI) and diffusion WI, which shifted from hyperintensity to hypointensity with size enlargement between two rounds of imaging examination. These lesions exhibited different enhancement patterns on dynamic contrast enhancement series. CONCLUSION The MRI signal change and in-/out-phase image might provide useful information and help radiologists establish the diagnosis of intrahepatic extramedullary hematopoiesis.

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Myeloproliferative Syndromes and Thrombocythemia

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Hepatic nodule: a case of primary myelofibrosis

Cited by 6 publications

References 10 publications

The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib

The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib

Magnetic resonance imaging features of intrahepatic extramedullary hematopoiesis: Three case reports

Myeloproliferative Syndromes and Thrombocythemia

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