Hepatic Metastases from the Spindle Cell Variant of Medullary Thyroid Carcinoma

Andrés, Carolina Ibarrola de; Megías, Victor Manuel Castellano; Carcavilla, C. Ballestin; Masgrau, Nuria Alberti; Barrios, Andrés Pérez; Agustín, Pedro de

doi:10.1159/000328348

Cited by 12 publications

(9 citation statements)

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“…Spindle cell variant MTC is a rare type of MTC, and only 5 cases have been reported in literatures thus far [ 1 – 5 ]. We reviewed 99 cases of MTC confirmed in our hospital from 2012 to 2019, only 4 cases spindle cell variant MTC meet the criteria, accounting for 4% of all MTC.…”

Section: Discussionmentioning

confidence: 99%

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Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

Wang

Yang

2021

Diagn Pathol

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Background Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare. Case presentation Here we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers. Conclusions We report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.

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Section: Discussionmentioning

confidence: 99%

“…More than 14 histological subtypes of MTC have been described in current WHO classification. Spindle cell variant MTC is a rare variant, and only 5 cases have been reported to date [ 1 – 5 ]. It is easy to mistake for other lesions due to its rarity and spindle cell morphology.…”

Section: Introductionmentioning

confidence: 99%

Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

Wang

Yang

2021

Diagn Pathol

View full text Add to dashboard Cite

show abstract

“…Spindle cell variant MTC is a rare type of MTC, and only 5 cases have been reported in literatures thus far [1][2][3][4][5]. We reviewed 99 cases of MTC con rmed in our hospital from 2012 to 2019, only 4 cases spindle cell variant MTC meet the criteria, accounting for 4% of all MTC.…”

Section: Discussionmentioning

confidence: 99%

“…More than 14 histological subtypes of MTC have been described in current WHO classi cation. Spindle cell variant MTC is a rare variant, and only 5 cases have been reported to date [1][2][3][4][5]. It is easy to mistake for other lesions due to its rarity and spindle cell morphology.…”

Section: Introductionmentioning

confidence: 99%

Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

Wang

Yang

2021

Preprint

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BackgroundMedullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare.Case presentationHere we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers.ConclusionsWe report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.

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“…Papillary carcinoma is the most common of these in North America. The most common site of metastasis is to lymph nodes in the neck [3][4]. Rarely, papillary and follicular carcinomas spread haematogenously, involving lung, liver, bone and occasionally brain [5].…”

Section: Introductionmentioning

confidence: 99%