Hepatic metallothionein and resistance to copper in juvenile coho salmon

Cu uptake, metabolism and elimination in fed and starved European eels (Anguilla anguilla) during adaptation to water-borne Cu exposure

“…This acclimation involves a restoration of the impaired branchial Na + uptake following physiological, biochemical and morphological modifications [12,14,16] and a decreased renal Na + excretion, largely due to increased tubular reabsorption [10]. Furthermore, we have previously shown that Cu acclimation by rainbow trout involves a restoration of plasma Cu concentrations after an increased turnover and clearance of plasma Cu [9].…”

Metallothionein induction and bioaccumulation kinetics of Cd and Ag in the marine fish Terapon jarbua challenged with dietary or waterborne Ag and Cu

“…For example, concentrations of metallothionein (MT), a class of lowmolecular weight, cysteine-rich metal-binding proteins (Kägi & Kojima 1987) that can sequester metals and protect from cellular metal toxicity (Roesijadi 1992), increased in the gills, kidney, liver and other organs of fish after metal exposure (McCarter & Roch 1983, Hollis et al 2001, Mayer et al 2003. In addition, ABSTRACT: A series of experiments were conducted to determine the effects of sublethal preexposure of dissolved and dietary silver (Ag) and copper (Cu) on the subsequent Ag and cadmium (Cd) bioaccumulation by the marine 3-line theraponids Terapon jarbua.…”

Copper-Binding Proteins in Liver of Bluegills Exposed to Increased Soluble Copper under Field and Laboratory Conditions

“…Direct evidence was obtained by McCarter and Roch (21), who measured the concentration of MTs in the livers of juvenile coho salmon that had been exposed to about 1, 50, 100, and 150 ,ug Cu/L. They found that the concentration of MT in the livers of fish exposed to increased soluble copper increased as a function of time to a maximum at 4 weeks exposure and thereafter remained more or less constant.…”

“…Considerable evidence is available indicating that fish pre-exposed to sublethal doses of metals are more tolerant of metals in subsequent exposures (12,17,21,(47)(48)(49)(50). For a few species, this increased tolerance has been related directly to the concentration of MTs (17,21). Information about increased tolerance of aquatic organisms related to the presence of increased quantities of MTs becomes important for predicting the capacity of ecosystems to receive additional quantities of metals, and for setting standards that protect the quality of the environment.…”

“…Fish have been exposed to mercury, zinc, and copper as well as cadmium . Experiments to determine the effect of copper exposure on MTs in fish have been perforned only on coho salmon (20)(21)(22) and rainbow trout (30)(31)(32). However, copper binding to MTs has been detected in the eel (23), flounder (9), chum salmon (10), killifish (27), skipjack (33), yellowtail (33), blackbream (33), and carp (33).…”