Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation

Cao, Yanan; Xue, Ying; Xue, Lu; Jiang, Xin; Wang, Xiaolin; Zhang, Zhijian; Yang, Jian; Lu, Jieli; Zhang, Chang Xian; Wang, Weiqing; Ning, Guang

doi:10.1016/j.jhep.2013.07.011

Cited by 58 publications

(54 citation statements)

References 48 publications

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“…[25][26][27][28] We have demonstrated that SIRT1 participates in the alleviation of chronic alcoholic liver injury by preventing fat accumulation, decreasing ROS production, and reducing inammation and cell death. 29,30 Interestingly, SIRT1 deacetylates a number of transcription factors, including histone H4, NF-kB, and p53.…”

Section: Introductionmentioning

confidence: 99%

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

et al. 2018

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“…Hepatic menin expression is decreased in aging and diabetic mice, and further downregulation leads to liver steatosis 98 . While Cheng et al tied hepatic menin expression to activation of genes involved in fatty acid oxidation, Cao et al associated loss of menin expression to activation of genes involved in fat deposition 97,98 .…”

Section: Metabolic Diseasementioning

confidence: 99%

“…While Cheng et al tied hepatic menin expression to activation of genes involved in fatty acid oxidation, Cao et al associated loss of menin expression to activation of genes involved in fat deposition 97,98 . Menin and SIRT1, a nuclear NAD + -dependent HDAC, bind at the promoter sites of several genes involved in fat deposition, including CD36, facilitating histone deacetylation and loss of expression 98 . Sirtuin1 is a regulator of FXR-dependent bile acid signaling 99 .…”

Section: Metabolic Diseasementioning

confidence: 99%

A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology

Ehrlich

Hall²,

Meng³

et al. 2017

gene expr

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Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome with neuroendocrine tumorigenesis of the parathyroid glands, pituitary gland, and pancreatic islet cells. The MEN1 gene codes for the canonical tumor suppressor protein, menin. Its protein structure has recently been crystallized, and it has been investigated in a multitude of other tissues. In this review, we summarize recent advancements in understanding the structure of the menin protein and its function as a scaffold protein in histone modification and epigenetic gene regulation. Furthermore, we explore its role in hepatobiliary autoimmune diseases, cancers, and metabolic diseases. In particular, we discuss how menin expression and function are regulated by extracellular signaling factors and nuclear receptor activation in various hepatic cell types. How the many signaling pathways and tissue types affect menin’s diverse functions is not fully understood. We show that small-molecule inhibitors affecting menin function can shed light on menin’s broad role in pathophysiology and elucidate distinct menin-dependent processes. This review reveals menin’s often dichotomous function through analysis of its role in multiple disease processes and could potentially lead to novel small-molecule therapies in the treatment of cholangiocarcinoma or biliary autoimmune diseases.

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“…By interacting with the multifunctional adaptor protein menin, SIRT1 is recruited to the promoter of CD36, a scavenger receptor involved in lipid transport, to promote H3 deacetylation; repression of CD36 transcription by SIRT1 reduces cholesterol influx and attenuates lipid accumulation in the liver. Consequently, mice with hepatocyte-restricted deletion of menin display enhanced steatohepatitis (Cao et al , 2013).…”

Section: Histone Modification and Steatohepatitismentioning

confidence: 99%

Decoding liver injury: A regulatory role for histone modifications

Tian

2015

The International Journal of Biochemistry & Cell Biology

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Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation

Cited by 58 publications

References 48 publications

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

Promotion of autophagosome–lysosome fusion via salvianolic acid A-mediated SIRT1 up-regulation ameliorates alcoholic liver disease

A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology

Decoding liver injury: A regulatory role for histone modifications

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