Abstract:Tangeretin
(TAN) exhibited antilipogenic, antidiabetic, and lipid-lowering
effects. However, the lipid biomarkers and the underlying mechanisms
for antiobesity and cholesterol-lowering effects of TAN have not been
sufficiently investigated. Herein, we integrated biochemical analysis
with lipidomics to elucidate its efficacy and mechanisms in high-fat
diet-fed rats. TAN at supplementation levels of 0.04 and 0.08% not
only significantly decreased body weight gain, serum total cholesterol,
and low-density lipopro… Show more
“…TAN ingested as 0.04, and 0.08 percent of the HFD for 6 weeks significantly lowered body weight gains. The lower body weights were mainly attributable to decreased adipose tissue produced with supplementation with TAN (Feng et al., 2020). In these HFD‐fed rats, the antiobesity and cholesterol‐lowering effects of TAN were linked to the ability of TAN to modulate hepatic lipid biosynthesis, particularly shown by sharply lowered levels of serum triglycerides and total‐C.…”
Two compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8‐heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high‐fat diet (HFD) in C57BL/6J mice. In the first 4 weeks, mice were fed either a standard diet (11% kcal from fat) for the control group, or a HFD (45% kcal from fat) to establish obesity in three experimental groups. In the following 4 weeks, two groups receiving the HFD were supplemented with either TAN or HMF at daily doses of 100 mg/kg body weight, while the two remaining groups continued to receive the standard healthy diet or the nonsupplemented HFD. Four weeks of supplementation with TAN and HMF resulted in intermediate levels of blood serum glucose, leptin, resistin, and insulin resistance compared with the healthy control and the nonsupplemented HFD groups. Blood serum peroxidation (TBARS) levels were significantly lower in the TAN and HMF groups compared with the nonsupplemented HFD group. Several differences occurred in the physiological effects of HMF versus TAN. TAN, but not HMF, reduced adipocyte size in the mice with pre‐existent obesity, while HMF, but not TAN, decreased fat accumulation in the liver and also significantly increased the levels of an anti‐inflammatory cytokine, IL‐10. In an analysis of the metabolites of TAN and HMF, several main classes occurred, including a new set of methylglucuronide conjugates. It is suggested that contrasts between the observed physiological effects of TAN and HMF may be attributable to the differences in numbers and chemical structures of TAN and HMF metabolites.
“…TAN ingested as 0.04, and 0.08 percent of the HFD for 6 weeks significantly lowered body weight gains. The lower body weights were mainly attributable to decreased adipose tissue produced with supplementation with TAN (Feng et al., 2020). In these HFD‐fed rats, the antiobesity and cholesterol‐lowering effects of TAN were linked to the ability of TAN to modulate hepatic lipid biosynthesis, particularly shown by sharply lowered levels of serum triglycerides and total‐C.…”
Two compounds from citrus peel, tangeretin (TAN) and 3′,4′,3,5,6,7,8‐heptamethoxyflavone (HMF), were investigated for their abilities to repair metabolic damages caused by an high‐fat diet (HFD) in C57BL/6J mice. In the first 4 weeks, mice were fed either a standard diet (11% kcal from fat) for the control group, or a HFD (45% kcal from fat) to establish obesity in three experimental groups. In the following 4 weeks, two groups receiving the HFD were supplemented with either TAN or HMF at daily doses of 100 mg/kg body weight, while the two remaining groups continued to receive the standard healthy diet or the nonsupplemented HFD. Four weeks of supplementation with TAN and HMF resulted in intermediate levels of blood serum glucose, leptin, resistin, and insulin resistance compared with the healthy control and the nonsupplemented HFD groups. Blood serum peroxidation (TBARS) levels were significantly lower in the TAN and HMF groups compared with the nonsupplemented HFD group. Several differences occurred in the physiological effects of HMF versus TAN. TAN, but not HMF, reduced adipocyte size in the mice with pre‐existent obesity, while HMF, but not TAN, decreased fat accumulation in the liver and also significantly increased the levels of an anti‐inflammatory cytokine, IL‐10. In an analysis of the metabolites of TAN and HMF, several main classes occurred, including a new set of methylglucuronide conjugates. It is suggested that contrasts between the observed physiological effects of TAN and HMF may be attributable to the differences in numbers and chemical structures of TAN and HMF metabolites.
“…Due to the negative feedback regulation of bile acid synthesis, interactions with plant compounds may cause an increase in the conversion of cholesterol to primary bile acids. Accordingly, activations of CYP7A1, the rate-limiting enzyme of bile acid synthesis, were described after diet interventions with plant compounds such as highly viscous apple pectin [114] or tangeretin, a flavonoid derived from citrus peel [115]. These studies indicate that the viscosity-related or molecular interactions described for these plant compounds may contribute to lowering blood cholesterol levels.…”
Section: Bile Acid Interactions and Influences On Healthmentioning
Plant compounds are described to interact with bile acids during small intestinal digestion. This review will summarise mechanisms of interaction between bile acids and plant compounds, challenges in in vivo and in vitro analyses, and possible consequences on health. The main mechanisms of interaction assume that increased viscosity during digestion results in reduced micellar mobility of bile acids, or that bile acids and plant compounds are associated or complexed at the molecular level. Increasing viscosity during digestion due to specific dietary fibres is considered a central reason for bile acid retention. Furthermore, hydrophobic interactions are proposed to contribute to bile acid retention in the small intestine. Although frequently hypothesised, no mechanism of permanent binding of bile acids by dietary fibres or indigestible protein fractions has yet been demonstrated. Otherwise, various polyphenolic structures were recently associated with reduced micellar solubility and modification of steroid and bile acid excretion but underlying molecular mechanisms of interaction are not yet fully understood. Therefore, future research activities need to consider the complex composition and cell-wall structures as influenced by processing when investigating bile acid interactions. Furthermore, influences of bile acid interactions on gut microbiota need to be addressed to clarify their role in bile acid metabolism.
“…This is important because NOB and TAN are very bitter compounds [25]. Feng et al [26] suggested an anti-obesity effect of TAN due to lower weight gain and body fat in rats that consumed 0.04% and 0.08% TAN mixed with a high-fat diet. Compared to the current experiment, these doses were 4.6 to 9.1 times higher, the initial body weight was 50% higher and, the intervention was longer (6 wk).…”
Polymethoxylated flavones (PMFs) have been associated with increased antioxidant activity in animal models. The effects of tangeretin (TAN) and nobiletin (NOB) on antioxidant activity in the blood and liver of rats were evaluated. Groups of rats were treated with 200 mg/kg bw/day of TAN or NOB, or placebo, for 15 days. Parental compounds and their metabolites were assessed in the liver by chromatographic analysis, in addition to α-tocopherol and retinol in the blood serum. Both TAN and NOB supplements were able to reduce malonaldehyde (MDA) in the rat’s blood by 22% and 18%, respectively, but only NOB increased redox reaction by 3%. Blood levels of retinol and α-tocopherol increased under TAN by 59% and 20%, respectively, but were not affected by NOB. Eight NOB metabolites were detected in the liver, but only two TAN metabolites were identified in low concentration. In conclusion, NOB improved antioxidant capacity and reduced lipid peroxidation, while increased levels of retinol and α-tocopherol after TAN supplement may have contributed to decreased blood lipid peroxidation.
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