Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

Lewis, Gary F.; Murdoch, Susan J.; Uffelman, Kristine D.; Naples, Mark; Szeto, Linda; Albers, Alegria; Adeli, Khosrow; Brunzell, John D.

doi:10.2337/diabetes.53.11.2893

Cited by 60 publications

(46 citation statements)

References 49 publications

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“…However, studies, including our own, show that inverse correlations exist between adiponectin levels and HL activity 81,82) . Moreover, it is recognized that HL activity is increased in a metabolic syndrome or an insulin resistance state [83][84][85] . These previous finding suggest that there is a similarity between changes in EL and HL in meta- …”

Section: Hl and Elmentioning

confidence: 99%

Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism

Kobayashi

Miyashita

Nakajima

et al. 2015

J Atheroscler Thromb

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Hepatic lipase (HL) is a key enzyme catalyzing the hydrolysis of triglycerides (TG) and phospholipids (PLs) in several lipoproteins. It is generally recognized that HL is involved in the remodeling of remnant, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and the production of small, dense low-density lipoproteins (sd-LDLs). On the other hand, it is unclear whether HL accelerates or retards atherosclerosis. From the clinical point of view, HL deficiency may provide useful information on answering this question, but the rarity of this disease makes it impossible to conduct epidemiological study. In this review, we describe a comprehensive and updated view of the clinical significance of HL on lipid and lipoprotein metabolism.

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Section: Hl and Elmentioning

confidence: 99%

Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism

Kobayashi

Miyashita

Nakajima

et al. 2015

J Atheroscler Thromb

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“…In one human study that examined the metabolism of HDL apoA-I using stable isotope enrichment methodology in eight T2DM individuals treated with pioglitazone for 14-16 weeks, there was no significant change in HDL apoA-I kinetic parameters, despite a significant increase of plasma HDL-C concentration by 14% (83). Rosiglitazone, another member of the thiazolidinedione class of antidiabetic agents, has been shown in animal studies to inhibit the transcription of hepatic lipase (84), raising the possibility that a reduction in hepatic lipase enzymatic activity may be one mechanism whereby this class of therapeutic agents increases plasma HDL levels.…”

Section: Hdl Kinetics In Humans Administered Pharmacotherapiesmentioning

confidence: 99%

Thematic review series: Patient-Oriented Research. What have we learned about HDL metabolism from kinetics studies in humans?

Rashid

Patterson

Lewis

2006

Journal of Lipid Research

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Plasma measurements of lipids, lipoproteins, and apolipoproteins provide information on the static levels of these fractions without providing key information on the dynamic fluxes of lipoproteins in the circulation. Kinetics studies, in contrast, provide additional information on the production and clearance rates of lipoproteins and the flow of lipids and apolipoproteins through lipoprotein fractions. This information is crucial in accurately delineating the metabolism of HDL in plasma, because plasma concentrations of HDL are the net result of the de novo production and catabolism of HDL as well as the recycling of HDL particles and the contribution to HDL from components of other lipoproteins. Studies aimed at measuring the metabolism of HDL particles have shown that HDL metabolism in vivo is complex and consists of multiple components. Kinetics studies provide a window into the metabolism of HDL, allowing us to better understand the mechanisms of HDL decrease in human conditions and the functionality of HDL particles. Here, we review the progress in our understanding of HDL metabolism derived from in vivo kinetics studies, focusing primarily on studies in humans but also reviewing key studies in animal models.-Rashid, S

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“…Hepatic lipase activity is regulated by several hormonal and metabolic factors (3). In insulin resistance, most studies show increased hepatic lipase activity, although the exact regulation of hepatic lipase in insulin resistance is still controversial (4). Adiponectin is a member of a class of bioactive substances known as adipocytokines (5).…”

mentioning

confidence: 99%

Low Plasma Adiponectin Levels Are Associated With Increased Hepatic Lipase Activity In Vivo

et al. 2005

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OBJECTIVE -Hepatic lipase plays a key role in hydrolyzing triglycerides and phospholipids present in circulating plasma lipoproteins. Plasma hepatic lipase activity is known to be regulated by several hormonal and metabolic factors, but hepatic lipase responsiveness to insulin is still controversial. Hypoadiponectinemia is known to be associated with insulin resistance, diabetes, and obesity. These conditions are often characterized by high plasma triglyceride and low HDL cholesterol levels, and they have been shown to be associated with high plasma hepatic lipase activity. We therefore raised the question whether adiponectin may be associated with plasma hepatic lipase activity in vivo.RESEARCH DESIGN AND METHODS -We measured plasma adiponectin and postheparin hepatic lipase activity in 206 nondiabetic men and in a second group of 110 patients with type 2 diabetes. The correlation of these parameters with markers of insulin resistance and systemic inflammation was investigated.RESULTS -In nondiabetic patients, adiponectin levels were significantly inversely correlated with plasma hepatic lipase activity (r ϭ Ϫ0.4, P Ͻ 0.01). These results were confirmed in the group of patients with type 2 diabetes (r ϭ Ϫ0.32, P ϭ 0.004). Multivariate analysis revealed that adiponectin was the strongest factor influencing hepatic lipase activity. The association was independent of age, sex, BMI, plasma triglycerides, insulin, HDL cholesterol, and highsensitivity C-reactive protein and accounted for ϳ10 and 12% of the variation in hepatic lipase activity in the two different patient cohorts, respectively.CONCLUSIONS -These results demonstrate for the first time a significant inverse association between adiponectin and postheparin plasma hepatic lipase activity that is independent of other factors such as markers of insulin resistance or inflammation. Therefore, adiponectin, rather than insulin, may represent an important factor contributing to the regulation of hepatic lipase activity in both nondiabetic individuals and patients with type 2 diabetes. The effect of adiponectin on hepatic lipase activity may also help to explain the HDL cholesterol-elevating action of adiponectin. Diabetes Care 28:2181-2186, 2005H epatic lipase functions as a lipolytic enzyme that hydrolyzes triglycerides and phospholipids in lipoproteins of intermediate and high density. It is thereby involved in the formation of small, dense LDL and represents a major determinant of the plasma HDL cholesterol concentration (1,2). Hepatic lipase activity is regulated by several hormonal and metabolic factors (3). In insulin resistance, most studies show increased hepatic lipase activity, although the exact regulation of hepatic lipase in insulin resistance is still controversial (4). Adiponectin is a member of a class of bioactive substances known as adipocytokines (5). It is related to tumor necrosis factor-␣ expression (6) and has the ability to suppress tumor necrosis factor-␣-induced activation of nuclear transcription factor B (7), thereby demonstrating anti...

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Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

Cited by 60 publications

References 49 publications

Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism

Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism

Thematic review series: Patient-Oriented Research. What have we learned about HDL metabolism from kinetics studies in humans?

Low Plasma Adiponectin Levels Are Associated With Increased Hepatic Lipase Activity In Vivo

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