Hepatic lipase (LIPC) C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver in Mexican population

Posadas-Sánchez, Rosalinda; Ocampo-Arcos, Wendy Angélica; Lopez-Uribe, Angel R.; Posadas‐Romero, Carlos; Villarreal-Molina, Teresa; Leon, E. Alvarez; Pérez-Hernández, Nonanzit; Rodríguez-Pérez, José Manuel; Cardoso-Saldaña, Guillermo; Moeini, Aida; Vargas‐Alarcón, Gilberto

doi:10.1016/j.yexmp.2014.12.010

Cited by 22 publications

(10 citation statements)

References 39 publications

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“…MDM2 encodes an ubiquitin ligase, which marks tumor suppressor proteins such as p53 for proteasomal degradation; its overexpression has been associated with increased susceptibility to tumor formation [42]. LIPC encodes a hepatic lipase with hydrolase activity for triglycerides and variants of this gene have been implicated in increased risk of cardiovascular disease [43] and T2D [44]. MAPK1 (also called p38-MAPK) is a member of the serine/threonine kinase, which acts as an essential component of the MAP kinase signal transduction pathway.…”

Section: Discussionmentioning

confidence: 99%

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children

Antúnez-Ortiz

Flores‐Alfaro

Burguete-García

et al. 2017

BioMed Research International

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Introduction. Increase in body weight is a gradual process that usually begins in childhood and in adolescence as a result of multiple interactions among environmental and genetic factors. This study aimed to analyze the relationship between copy number variants (CNVs) in five genes and four intergenic regions with obesity in Mexican children. Methods. We studied 1423 children aged 6–12 years. Anthropometric measurements and blood levels of biochemical parameters were obtained. Identification of CNVs was performed by real-time PCR. The effect of CNVs on obesity or body composition was assessed using regression models adjusted for age, gender, and family history of obesity. Results. Gains in copy numbers of LEPR and NEGR1 were associated with decreased body mass index (BMI), waist circumference (WC), and risk of abdominal obesity, whereas gain in ARHGEF4 and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d and losses in INS were associated with increased BMI and WC. Conclusion. Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children.

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Section: Discussionmentioning

confidence: 99%

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children

Antúnez-Ortiz

Flores‐Alfaro

Burguete-García

et al. 2017

BioMed Research International

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“…[17] The influence that this gene has on the metabolism of glycerophospholipids[49] may also alter plasma concentrations thereof. Results published by Posadas-Sánchez et al [50] suggested that the LIPC C-154T polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors: under dominant model, the TT genotype was associated with increased levels of triglycerides/HDL-c index ( P = 0.046). On the other hand, the same genotype was associated with the presence of small LDLs ( P = 0.003).…”

Section: Discussionmentioning

confidence: 98%

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes

Martín¹,

Rojo²,

Vilar³

et al. 2019

Ann Pediatr Card

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Background: Dyslipidemias have increased during the last decades in children. Aim: The objective of this study was to analyze the influence of different polymorphisms in plasma triglyceride levels of children following a dietary treatment with plant sterols. Design: A randomized, double-blind, crossover, controlled clinical trial was carried out in 26 children (16 women). Materials and Methods: Commercial milk, with 2.24 g sterols, was ingested daily during 3 weeks , and the same amount of kimmed milk without sterols, during the 3 week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Results: Apolipoprotein A5 Ser19Trp ( P = 0.002), peroxisome proliferator-activated receptor-alpha L162V ( P = 0.003), APOE APOE2/3/4 ( P = 0.012), and APOE APOE2,3,4 ( P = 0.025) show statistically significant differences between their haplotypes in plasma triglyceride levels. Other genes did not show statistically significant differences. Conclusions: Further studies are needed to establish which genotype combinations would be the most protective against hypertriglyceridemia.

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“…Since the metabolism of glycerophospholipids is influenced by the hepatic lipase gene, it is believed that it may also alter HDL-cholesterol plasma concentrations [42]. As suggested by Posadas-Sanchez et al [43], the TT genotype of LIPC C-154T polymorphism is related to higher levels of triglycerides/HDL-cholesterol index ( p = 0.046) and triglycerides ( p = 0.0002), under a dominant model. Since the metabolism of glycerophospholipids is influenced by the hepatic lipase gene, it is believed that it may also alter HDL-cholesterol plasma concentrations [42].…”

Section: Discussionmentioning

confidence: 99%

Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study

Martín¹,

Vilar²,

Rojo³

et al. 2019

Nutrients

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Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia.

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Hepatic lipase (LIPC) C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver in Mexican population

Cited by 22 publications

References 39 publications

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children

Modulation of plasma triglycerides concentration by sterol-based treatment in children carrying different genes

Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study

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