Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis

Chapman, Roger W.; Morgan, Marsha Y.; Laulicht, M; Hoffbrand, A. V.; Sherlock, Sheila

doi:10.1007/bf01316575

Cited by 191 publications

(90 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, liver iron varies with the pathological changes induced by alcohol consumption [100] and the uptake of iron from asialotransferrin is, at least in vitro, too fast to explain the rather modest increase in liver iron stores in alcoholism. Thus, if the content of sialic acid in transferrin is a pathogenetic factor to liver iron storage in alcoholism, additional mechanisms must also be looked for.…”

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 98%

“…Ethanol affects iron homeostasis in a number of ways, the most conspicuous clinical manifestations being fatty liver, liver cirrhosis and hepatic siderosis [99][100][101]. The mechanisms behind liver iron accumulation associated with excess ethanol intake are obscure.…”

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 99%

“…The mechanisms behind liver iron accumulation associated with excess ethanol intake are obscure. This arises largely from the fact that the mechanisms may change during the progress of the condition from normality to manifest and life-threatening liver failure [99][100][101]. Also, one has to cope with the problem of extrapolating from findings in experimental animals to the situation in situ in man.…”

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 99%

“…Other possible mechanisms for excess liver iron during alcohol abuse are increased iron intake and absorption, deranged intermediary metabolism and hepatocyte damage [99][100][101][118][119][120]. As yet, definite proofs for their significance are lacking.…”

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 99%

See 3 more Smart Citations

The role of transferrin in the mechanism of cellular iron uptake

Thorstensen

Romslo

1990

Biochemical Journal

185

106

View full text Add to dashboard Cite

INTRODUCTIONThe role of transferrin and its cell surface receptor in cellular iron metabolism has received considerable interest during the last decade. Hence, over this period several reviews covering various aspects of the topic have been published.In this review we attempt to summarize the new knowledge and controversies encountered during the last 4-5 years. The focus is on iron metabolism by the hepatocyte. We also view the concept of transferrin-cell interactions from angles which previously may not have been given particular attention, and we include some aspects of iron metabolism not normally covered by reviews of this type. Central parts of what may be regarded as well-established knowledge either have been entirely omitted, or are only briefly described or mentioned to the extent considered relevant to the particular topic discussed. Important aspects of iron metabolism such as iron adsorption, haemochromatosis, ferritin iron and iron in infection and neoplasia are not covered in the present paper. Instead, the reader is referred to one or more of the recently published reviews [1-5] and references therein.

show abstract

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 98%

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 99%

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 99%

Section: Transferrin and Alcoholic Liver Diseasementioning

confidence: 99%

See 2 more Smart Citations

The role of transferrin in the mechanism of cellular iron uptake

Thorstensen

Romslo

1990

Biochemical Journal

185

106

View full text Add to dashboard Cite

show abstract

“…In this retro-sis. [3][4][5][6][7][8][9] In this study, we have re-examined the spective study, the clinical features, iron status, alcohol prevalence of alcohol use in hereditary hemochromatohistory, liver histology, and long-term survival were re-sis using rigid criteria for the diagnosis, including the viewed in 105 homozygotes for hemochromatosis using presence of an HLA identical sibling with hemochromarigid diagnostic criteria including an HLA identical sib-tosis.ling with iron overload. Heavy alcohol consumption (ú80 g ethanol/day) was found in 15% of hemochromato-PATIENTS AND METHODS sis patients.…”

mentioning

confidence: 99%

Alcoholism in hereditary hemochromatosis revisited: Prevalence and clinical consequences among homozygous siblings

1996

View full text Add to dashboard Cite

The relationship between alcoholism and hereditary hemochromatosis performed before the use of these dihemochromatosis remains controversial. Previous stud-agnostic tools most likely included patients with alcoies have included patients with alcoholic siderosis holic siderosis rather than hereditary hemochromatorather than hereditary hemochromatosis. In this retro-sis. [3][4][5][6][7][8][9] In this study, we have re-examined the spective study, the clinical features, iron status, alcohol prevalence of alcohol use in hereditary hemochromatohistory, liver histology, and long-term survival were re-sis using rigid criteria for the diagnosis, including the viewed in 105 homozygotes for hemochromatosis using presence of an HLA identical sibling with hemochromarigid diagnostic criteria including an HLA identical sib-tosis.ling with iron overload. Heavy alcohol consumption (ú80 g ethanol/day) was found in 15% of hemochromato-PATIENTS AND METHODS sis patients. Histological features of alcoholic liver disease (Mallory's hyaline bodies, pericentral fibrosis, polyPatient records were reviewed from a large database of 170 morphonuclear infiltrate, and fatty infiltration) were hemochromatosis homozygotes that have been documented uncommon in hemochromatosis. Hemochromatosis pa-since 1965. Family investigations at this center ranged from tients with heavy alcohol consumption had a higher no further investigation in the case of isolated proband cases prevalence of cirrhosis than hemochromatosis patients to extensive pedigree analysis involving up to 45 family memwithout heavy alcohol consumption. Hepatic iron con-bers of a single family over multiple generations. Data was centration and hepatic iron index did not significantly available on 483 family members assessed at this tertiary differ between these two hemochromatosis groups. referral center for possible hemochromatosis. The clinical feaLong-term survival was significantly reduced in patients tures of this patient cohort has been previously described. [10][11][12] with heavy alcohol consumption (mean follow-up, 9.22 From this database, homozygotes were selected that had an years). This suggests that chronic alcohol consumption HLA identical sibling with hemochromatosis to establish a has an additive hepatotoxic effect despite the paucity of hereditary disorder of iron metabolism (n Å 105). There were histological features of alcoholic liver disease. (HEPATOL-65 homozygotes excluded from this study because no HLA OGY 1996;23:724-727. ) identical sibling had been identified. The diagnosis was confirmed by liver biopsy results in all probands and most discovered siblings (n Å 89/105). No hemochromatosis patients hadThe clinical distinction between patients with heredconcomitant chronic viral hepatitis B or C on histological itary hemochromatosis and alcoholic siderosis contin-examination of the liver biopsy specimen. Liver biopsy reues to be a diagnostic problem. Clinical tools that have ports were reviewed for the presence of Mallory's hyaline, improved this diagnostic di...

show abstract