Hepatic Insulin Sensitivity Assessed by Integrated Model of Hepatic and Peripheral Glucose Regulation

Tokuyama, Kumpei; Nagasaka, Shoichiro; Mori, Schuuichi; Takahashi, Nirei; Kusaka, Ikuyo; Kiyonaga, Akira; Tanaka, Hiroaki; Shindo, Munehiro; Ishibashi, Shun

doi:10.1089/dia.2009.0011

Cited by 5 publications

(9 citation statements)

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“…An integrated two-compartment mathematical model [16] was used to estimate the time course of endogenous glucose production ( EGP ) in mg/kg/min. EGP primarily reflects hepatic glucose production [17,18].…”

Section: Methodsmentioning

confidence: 99%

“…EGP primarily reflects hepatic glucose production [17,18]. Indexes of insulin sensitivity specific to glucose disposal ( Disposal S i ) and hepatic insulin action (Hepatic S i ) were calculated [16]. The same model was used to derive indexes of disposal and hepatic glucose effectiveness ( Disposal S g and Hepatic S g ) as estimates of the ability of glucose itself to promote disposal and suppress EGP, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…The same model was used to derive indexes of disposal and hepatic glucose effectiveness ( Disposal S g and Hepatic S g ) as estimates of the ability of glucose itself to promote disposal and suppress EGP, respectively. Details of the integrated two-compartment minimal model have been previously described by Tokuyama et al[16], and indexes from the model are summarized by the following equations:…”

Section: Methodsmentioning

confidence: 99%

“…In 2005, researchers expanded on the traditional two-compartment minimal model by describing endogenous glucose production (EGP) from tracer-labeled IVGTT data [15]. In 2009, Tokuyama and colleagues further developed the two-compartment model framework by introducing model-derived insulin sensitivity indexes specific to hepatic glucose regulation [16]. Thus, these latest advances in two-compartment modeling offer the opportunity to provide novel data comparing disposal-specific insulin sensitivity, hepatic insulin sensitivity, and hepatic glucose production in AA and EA.…”

Section: Introductionmentioning

confidence: 99%

“…The aim of this study was to describe insulin action and hepatic glucose metabolism among non-diabetic, premenopausal women of AA and EA ancestry using a recently-introduced integrated model [16] with the goal of determining whether lower insulin sensitivity among AA may be attributed to either hepatic or peripheral sensitivity to insulin.…”

Section: Introductionmentioning

confidence: 99%

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Ethnic differences in glucose disposal, hepatic insulin sensitivity, and endogenous glucose production among African American and European American women

et al. 2012

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Objective Intravenous glucose tolerance tests (IVGTT) have demonstrated lower whole-body insulin sensitivity (SI) among African Americans (AA) compared to European Americans (EA). Whole-body SI represents both insulin-stimulated glucose disposal, primarily by skeletal muscle, and insulin's suppression of endogenous glucose production (EGP) by liver. A mathematical model was recently introduced that allows for distinction between disposal and hepatic insulin sensitivity. The purpose of this study was to examine specific indexes of insulin sensitivity among AA and EA women to determine whether lower whole-body insulin sensitivity in AA may be attributed to insulin action at muscle, liver, or both. Methods Participants were 53 non-diabetic, premenopausal AA and EA women. Profiles of EGP and indexes of Disposal SI and Hepatic SI were calculated by mathematical modeling and incorporation of a stable isotope tracer (6,6-2H2glucose) into the IVGTT. Body composition was assessed by dual energy X-ray absorptiometry. Results After adjustment for percent fat, both Disposal SI and Hepatic SI were lower among AA (p=0.009 for both). Time profiles for serum insulin and EGP revealed higher peak insulin response and corresponding lower EGP among AA women compared to EA. Conclusions Indexes from a recently-introduced mathematical model suggest that lower whole-body insulin sensitivity among non-diabetic AA women is due to both hepatic and peripheral components. Despite lower Hepatic SI, AA displayed lower EGP, resulting from higher post-challenge insulin levels. Future research is needed to determine the physiological basis of lower insulin senstivity among AA and its implications for type 2 diabetes risk.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ethnic differences in glucose disposal, hepatic insulin sensitivity, and endogenous glucose production among African American and European American women

et al. 2012

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Current literature in diabetes

2010

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Index of glucose effectiveness derived from oral glucose tolerance test

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Aim of this study was to formulate an index for glucose effectiveness (Sg), SgIo, based on 3-point (0, 30 and 120 min) 75 g oral glucose tolerance test (OGTT). The equation for SgI(O) was developed in the Chikuma cohort (n = 502). Firstly, post-loading plasma glucose without insulin action and Sg (PPG-without insulin and Sg) was calculated as follows: fasting plasma glucose (mg/dl) + [0.75 × 75,000]/[0.19 × BW(kg) × 10]. Secondly, 'PPG-without insulin/with Sg' was obtained from inverse correlation between log(10)DI(O) and 2-h post-glucose plasma glucose at OGTT (2hPG) in each glucose tolerance category: DI(O) denotes oral disposition index, a product of the Matsuda Index and δIRI(0-30)/δPG(0-30). Thirdly, expected 2hPG (2hPG(E)) of a given subject was obtained from the regression, and the ratio of 2hPG to 2hPG(E) (2hPG/2hPG(E)) was determined as an adjustment factor. Lastly, SgI(O) ([mg/dl]/min) was calculated as [PPG-without insulin and Sg]-[PPG-without insulin / with Sg] x [(2hPG) / 2hPG(E)]. SgI(O) was validated against Sg obtained by frequently sampled intravenous glucose tolerance test in the Jichi cohort (n = 205). Also, the accuracy of prediction of Sg by SgIo was tested by the Bland-Altman plot. SgI(O) was 3.61 ± 0.73, 3.17 ± 0.74 and 2.15 ± 0.60 in subjects with normal glucose tolerance (NGT), non-diabetic hyperglycemia and diabetes, respectively, in the Chikuma cohort. In the Jichi cohort, SgI(O) was significantly correlated with Sg in the entire group (r = 0.322, P < 0.001) and in subjects with NGT (r = 0.286, P < 0.001), and SgIo accurately predicted Sg. In conclusion, SgI(O) could be a simple, quantitative index for Sg.

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Hepatic Insulin Sensitivity Assessed by Integrated Model of Hepatic and Peripheral Glucose Regulation

Abstract: Because insulin resistance in liver and peripheral tissue may play a differential role in the pathogenesis of diabetes, this analysis can serve as a simple one-step approach to obtain metabolic indexes specific to EGP suppression and stimulating glucose uptake.

Cited by 5 publications

References 11 publications

Ethnic differences in glucose disposal, hepatic insulin sensitivity, and endogenous glucose production among African American and European American women

Ethnic differences in glucose disposal, hepatic insulin sensitivity, and endogenous glucose production among African American and European American women

Current literature in diabetes

Index of glucose effectiveness derived from oral glucose tolerance test

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