Hepatic hypertrophic osteoarthropathy and liver transplantation.

Pitt, P; Mowat, A M; Williams, R; Hamilton, Emma

doi:10.1136/ard.53.5.338

Cited by 17 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypertrophic osteoarthropathy can be a painful syndrome of arthritis and joint deformities that has been observed in chronic liver disease, including biliary atresia 118, 119. In some circumstances, it has been responsive to standard anti‐inflammatory treatments.…”

Section: Hypertrophic Osteoarthopathymentioning

confidence: 99%

Biliary atresia: A transplant perspective

Shneider

Mazariegos

2007

Liver Transpl

View full text Add to dashboard Cite

Section: Hypertrophic Osteoarthopathymentioning

confidence: 99%

Biliary atresia: A transplant perspective

Shneider

Mazariegos

2007

Liver Transpl

View full text Add to dashboard Cite

“…In addition to juvenile polypo- sis, previous reports described PDP associated with other hamartomatous disorders, such as cystic fibrosis in the lung or liver. 13,19 Juvenile polyposis is often observed in the colon, but it is relatively rare in the stomach and the small bowel. Watanabe et al 20 reported a rare case of juvenile polyposis limited to the stomach.…”

Section: Discussionmentioning

confidence: 99%

Pachydermoperiostosis associated with juvenile polyps of the stomach and gastric adenocarcinoma

Ikeda

Okada

Mizuno

et al. 2004

Journal of Gastroenterology

View full text Add to dashboard Cite

Pachydermoperiostosis (PDP) is a rare syndrome, and the presence of digital clubbing, radiographic periostosis, and coarse facial features are the main diagnostic criteria. Here, we report patient with the primary form of PDP in whom juvenile polyps and gastric cancer developed within 9 years of follow-up. A 27-year-old Japanese man, diagnosed as having the primary form of PDP at 14 years of age, was referred to our department for assessment of chronic anemia. On upper gastrointestinal endoscopic examination, multiple polypoid lesions with a huge polyp were found in the stomach, and biopsy findings indicated juvenile polyps, although no polypoid lesion had been present at the age of 18 years. Bleeding from these polyps was suspected, and endoscopic mucosal resection of the polypoid lesions was performed. Histology of the huge polyp showed hamartoma, adenoma, and adenocarcinoma in part. This is the first case report of the primary form of PDP associated with gastric cancer. In this patient, juvenile polyps and gastric cancer developed within 9 years of follow-up, indicating that the primary form of PDP may be a high risk factor for gastric cancer, and that periodical follow-up with upper gastrointestinal endoscopy is important.

show abstract

“…Hypertrophic osteoarthropathy with associated arthritis was described in patients with hepatic failure and transplantation (23). It has been emphasized that when HOA occurs in the setting of liver disease it usually heralds a worsening of hepatic function (6). The pathogenesis of HOA is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Osteoarthritic changes due to osteopenia and rheumatic complications were also reported following transplantation (5). Hepatic hypertrophic osteoarthropathy (HOA) has been documented in case reports (6,7,8,9,10). In addition to metabolic bone disease, metastatic bone disease was encountered following long periods of cirrhosis giving rise to the high incidence of hepatocellular carcinoma (HCC) (11,12).…”

Section: Introductionmentioning

confidence: 99%

Osseous and Nonosseous Bone Scan Findings in Liver Transplant Candidates with end-stage Chronic Liver Disease

Erhamamci¹,

Aktaş²,

Bahçeci³

et al. 2013

MIRT

View full text Add to dashboard Cite

Objective: End-stage chronic liver disease (CLD) adversely affects the function of multiple organ systems including the skeletal system. The aim of this study was to assess osseous and nonosseous bone scintigraphy (BS) findings in liver transplant (LT) candidates with end-stage CLD.Methods: We retrospectively evaluated BS findings in 50 consecutive patients with end-stage CLD who were undergoing preoperative assessment for LT from January 2006 to December 2011. All the patients were analyzed with respect to clinical and laboratory parameters, and BS findings. Scintigrams were visually assessed for the presence of osseous and nonosseous abnormalities. Osseous abnormalities were classified as those indicating bone metabolism changes or metastatic bone disease. Typical scintigraphic findings denoting to changes in bone metabolism were the presence of decreased osseous uptake, increased periarticular uptake, asymmetrical or unusual uptake patterns. Nonosseous findings were classified according to the degree of soft-tissue uptake as mild and severe.Results: The group consisted of 46 adult and 4 adolescent patients. All adolescent patients had normal skeletal accumulation with growth plate uptake and one had mildly increased renal cortical activity. A total of 46 adult patients had one or more of the following osseous findings: generalized decrease in osseous uptake (n=4, 8.7%); bilateral decrease in lower extremity uptake (n=26, 56.5%); symmetrically increased periarticular uptake (n=26, 56.5%); bilateral cortical/periosteal increased uptake in the lower extremity indicating hepatic hypertrophic osteoarthropathy (HOA) (n=8, 17.4%); bilateral increased sacroiliac activity (n=16, 34.8%); sacral activity (n=10, 21.7%), coccygeal activity (n=2, 4.3%), focally increased uptake suggestive of metastases (n=5, 10.9%). Three rib metastases appeared to be linear. Nonosseous findings observed in adult patients were mild diffuse liver uptake (n=4, 8.7%) and bilateral diffuse mild or severe degree of renal cortical uptake (n=20, 43.5%). There was a statistically significant difference in serum creatinine values between mild and severe renal uptake groups (p<0.05). There was also statistically significant difference in serum BUN and creatinine values between patients with severe degree of renal uptake and without renal uptake (p<0.05).Conclusion: The results of the current study has shown that adolescent LT candidates with end-stage CLD had no osseous abnormality on BS. However, all of adult patients exhibited one or one more osseous abnormalities. Typical scintigraphic findings denoting to abnormalities in bone metabolism were generalized decreased osseous uptake, decreased lower extremity osseous uptake, increased periarticular uptake, increased cortical/periosteal uptake indicating hepatic HOA, and other unusual uptake patterns. Hepatocellular carcinoma metastases may present itself as rib metastases linear in pattern. Soft-tissue uptake in the form of diffuse bilateral mild or severe degree of renal uptake and less commonly mil...

show abstract

Hepatic hypertrophic osteoarthropathy and liver transplantation.

Abstract: Objectives-To document the variety of liver diseases and the clinical picture of hepatic hypertrophic osteoarthropathy

Cited by 17 publications

References 6 publications

Biliary atresia: A transplant perspective

Biliary atresia: A transplant perspective

Pachydermoperiostosis associated with juvenile polyps of the stomach and gastric adenocarcinoma

Osseous and Nonosseous Bone Scan Findings in Liver Transplant Candidates with end-stage Chronic Liver Disease

Contact Info

Product

Resources

About