Hepatic granulomas: a 15‐year experience in the Royal Adelaide Hospital

Anderson, Claire; Nicholls, Jonathan; Rowland, R.; Jt, LaBrooy

doi:10.5694/j.1326-5377.1988.tb104510.x

Cited by 34 publications

(3 citation statements)

References 6 publications

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“…They do not have independent significance and are unlikely to be associated with major parenchymal abnormalities. 12 …”

Section: Histopathologymentioning

confidence: 99%

“…Granulomas are occasionally reported in association with hepatotropic viruses like hepatitis A, B, and C. 7 9 12 Transient fibrin-ring granulomas were observed in a patient with acute hepatitis A and disappeared during the recovery phase. 72 Transient epithelioid granulomas were found in 2% of the patients with hepatitis C; the authors had explored the possible association of granulomas with interferon-alpha treatment; however, only 1 patient of the 5 identified had granulomas on posttreatment biopsy and lacking specific features of DILI.…”

Section: Etiologymentioning

confidence: 99%

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Granulomatous liver diseases

Mironova,

Gopalakrishna,

Rodriguez Franco

et al. 2024

Hepatology Communications

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A granuloma is a discrete collection of activated macrophages and other inflammatory cells. Hepatic granulomas can be a manifestation of localized liver disease or be a part of a systemic process, usually infectious or autoimmune. A liver biopsy is required for the detection and evaluation of granulomatous liver diseases. The prevalence of granulomas on liver biopsy varies from 1% to 15%. They may be an incidental finding in an asymptomatic individual, or they may represent granulomatous hepatitis with potential to progress to liver failure, or in chronic disease, to cirrhosis. This review focuses on pathogenesis, histological features of granulomatous liver diseases, and most common etiologies, knowledge that is essential for timely diagnosis and intervention.

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“…They do not have independent significance and are unlikely to be associated with major parenchymal abnormalities. 12 …”

Section: Histopathologymentioning

confidence: 99%

Section: Etiologymentioning

confidence: 99%

Granulomatous liver diseases

Mironova,

Gopalakrishna,

Rodriguez Franco

et al. 2024

Hepatology Communications

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show abstract

“…Hepatitis B, alcohol or chronic liver disease due to haemochromatosis, sarcoidosis, tuberculosis, neoplasms, agents of infection and medicines are among these pathologies. 6 Anderson et al 7 established sarcoidosis in 12% of patients with hepatic granuloma.…”

Section: Sarcoidosis With Granulomatous Hepatitis and Autoimmune Endo...mentioning

confidence: 99%

Sarcoidosis with Granulomatous Hepatitis and Autoimmune Endocrine Involvement

Kalkan

Kalkan²,

Tüzün

et al. 2008

Ann Acad Med Singap

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Risk of Acute Liver Injury Associated With the Combination of Amoxicillin and Clavulanic Acid

Rodrı́guez

Stricker²,

Zimmerman³

1996

Arch Intern Med

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They were 35 cases of idiopathic acute liver injury. None was fatal. There were 14 cases of acute liver injury among users of amoxicillin alone. The type of liver injury was hepatocellular in half the cases. There were 21 cases of acute liver injury among users of amoxicillin and clavulanic acid together. The type of liver injury was cholestatic in three quarters of the cases. The incidence rates and 95% confidence intervals (CIs) of developing acute liver injury associated with the combination of amoxicillin and clavulanic acid and amoxicillin alone were 1.7 (1.1-2.7) and 0.3 (.02-0.5) per 10 000 prescriptions, respectively. The rate ratios and 95% CIs of acute liver injury for amoxicillin and clavulanic acid together compared with amoxicillin alone were 6.3 (3.2-12.7) for all patients and 8.4 (3.6-20.8) for patients presenting with jaundice. Among users of amoxicillin and clavulanic acid together, the risk of developing acute liver injury was more than 3 times greater after a course of 2 or more consecutive prescriptions than after a single course of therapy. The risk also increased with age among users of amoxicillin and clavulanic acid together. The combination of advancing age and repeated prescriptions resulted in a risk of developing acute liver injury greater than 1 per 1000 users of amoxicillin and clavulanic acid together.

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Hepatic granulomas: a 15‐year experience in the Royal Adelaide Hospital

Cited by 34 publications

References 6 publications

Granulomatous liver diseases

Granulomatous liver diseases

Sarcoidosis with Granulomatous Hepatitis and Autoimmune Endocrine Involvement

Risk of Acute Liver Injury Associated With the Combination of Amoxicillin and Clavulanic Acid

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