Hepatic Function Before and After Resection of Liver

Flynn, F. V.; Walshe, J. M.

doi:10.1136/bmj.1.4721.1484

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Its concentration in blood plasma is very low. Though not normally present it has been found in urine of a man from whom part of the liver containing a tumour was removed (Flynn & Walshe, 1951). We have not examined rat urine after partial hepatectomy.…”

Section: Ethanolamine Phosphoric Estermentioning

confidence: 99%

Free amino‐acids in liver and blood after partial hepatectomy in normal and adrenalectomized rats

Ferrari¹,

Harkness²

1954

The Journal of Physiology

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It is well known that, after removal of part of the liver of the rat, the remainder grows rapidly to reach the normal size in 2-3 weeks (Higgins & Anderson, 1931). Though many aspects of this growth process have been investigated, little attention has been paid to changes in amino-acid metabolism. Since the liver plays a prominent part in the metabolism of these substances, one would expect that there might be changes in their concentration, both in the liver and in the blood, after partial hepatectomy, and that these changes might even be related causally to the subsequent regeneration. Christensen, Rothwell, Sears & Streicher (1948) have reported a considerable rise in the concentration of free amino-acids of rat liver cells 1-3 days after partial hepatectomy, though they found no significant change in the blood plasma; Des Marais & Dugal (1948), on the other hand, found a rise in free amino-acids of plasma in the first day after partial hepatectomy. Christensen et al. (1948) give some data on glycine and glutamine, and the peptide glutathione, but this appears to be the only information available at present. Thus although there is some information about a change in total concentration of amino-acids in liver and blood, of the individual compounds little is known. The work described here was undertaken with the object of filling this gap. For this purpose the technique of filter-paper chromatography was chosen. It was felt that, in a preliminary investigation of this sort, the disadvantages of this method on the quantitative side were outweighed by its simplicity and wide application, and that it would be more useful to have information about a wide range of substances within fairly wide limits of accuracy, than more exact information about a few. This method has been used in conjunction with estimation of total free carboxyl-amino nitrogent (Hamilton & Van Slyke, 1943) in liver and plasma.The investigation was confined to the first 24 hr after partial hepatectomy. t This term will be shortened to amino-nitrogen in the rest of this paper.

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Section: Ethanolamine Phosphoric Estermentioning

confidence: 99%

Free amino‐acids in liver and blood after partial hepatectomy in normal and adrenalectomized rats

Ferrari¹,

Harkness²

1954

The Journal of Physiology

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show abstract

“…elsewhere (Flynn and Walshe, 1951 Urine for chromatographic analysis was taken during the course of deep x-ray therapy to the liver; the amino-acid pattern and concentration were normal except for a slight excess of cystine.…”

Section: Diagnostic Valuementioning

confidence: 99%