Hepatic fat as a novel marker for high-risk coronary atherosclerotic plaque features in familial hypercholesterolaemia

Huangfu, G.; Jaltotage, Biyanka; Pang, Jing; Lan, N.; Abraham, Arun; Otto, Jacobus; Ihdayhid, Abdul Rahman; Rankin, James M.; Chow, Benjamin J.W.; Watts, Gerald F.; Ayonrinde, Oyekoya T.; Dwivedi, Girish

doi:10.1016/j.metabol.2022.155370

Metabolism

2023

DOI: 10.1016/j.metabol.2022.155370

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Hepatic fat as a novel marker for high-risk coronary atherosclerotic plaque features in familial hypercholesterolaemia

G. Huangfu

Biyanka Jaltotage²,

Jing Pang³

et al.

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Cited by 4 publications

(1 citation statement)

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“…Similarly, pharmacological agents should target the reduction of the overall metabolic milieu 422 rather than a disease in isolation [46]. Emerging evidence on the beneficial effects of glucagon-like 423 peptide-1 receptor agonists (GLP1-RA) that help improve weight loss, reduce hepatic fat, glycemic 424 levels and importantly, cardiovascular events [47], offer hope for future reduction in obesity-related 425 mortality [48]. 426 427…”

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confidence: 99%

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

Chong¹,

Kong²,

Kannan³

et al. 2023

Metabolism

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mentioning

confidence: 99%

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

Chong¹,

Kong²,

Kannan³

et al. 2023

Metabolism

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Hepatic Steatosis and High-Risk Coronary Plaque

Sukudom,

Wee,

Huangfu

et al. 2024

JACC: Cardiovascular Imaging

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Atherosclerosis as the Damocles’ sword of human evolution: insights from nonhuman ape-like primates, ancient human remains, and isolated modern human populations

Kumar,

Huangfu,

Figtree

et al. 2024

American Journal of Physiology-Heart and Circulatory Physiology

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Atherosclerosis contributes to the majority of deaths worldwide, and classic descriptions of atherosclerosis include lipid accumulation, old age, and cigarette smoking. The role of the immune system in atherogenesis is becoming increasingly accepted. Evolutionary biology provides evidence for significantly different immune responses between humans and chimpanzees, especially regarding the caspase-12 and the inflammasome, T-cell inhibitory sialic acid-recognizing lectin expression, and possibly an overreactive innate damage-associated molecular pattern-mediated response. Neurobiological stress also has a role in the development of atherosclerosis, and comparative neurobiology provides further evidence for the human susceptibility to atherosclerosis. An examination of the evolution across the genus of Homo suggests a range of possible evolutionary pressures that contribute to the immunological and metabolic factors predisposing to atherosclerosis (including migration, exposure to pathogens, and adaptations for harsh environments). This concept of genetic pleiotropy between atherosclerosis and evolutionary success is supported by modern evidence of archaic admixture and gene polymorphisms in isolated human populations. Furthermore, in recent years, emerging technologies including gene editing, designer anti-sense oligonucleotides and small interfering RNA are being employed as a treatment for atherogenic dyslipidemia. However, considering evolution as a mechanistic process and atherosclerosis as part of the inertia of evolution, important questions surrounding the safety of these interventions are unveiled.

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Hepatic fat as a novel marker for high-risk coronary atherosclerotic plaque features in familial hypercholesterolaemia

Cited by 4 publications

References 53 publications

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

Hepatic Steatosis and High-Risk Coronary Plaque

Atherosclerosis as the Damocles’ sword of human evolution: insights from nonhuman ape-like primates, ancient human remains, and isolated modern human populations

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