Hepatic Failure Related to Itraconazole Use Successfully Treated by Corticosteroids

Lou, Horng-Yuan; Fang, Chia‐Lang; Fang, Sheng-Uei; Tiong, Cheng; Cheng, Yang-Chih; Chang, Chun Chao

doi:10.5812/kowsar.1735143x.1402

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…Treatments for eumycetoma, such as antifungal medications, may need to be adjusted or closely monitored in patients who also have hepatitis B. This is because antifungal affect the liver function, 19 and close monitoring of liver function is necessary to ensure the safety and effectiveness of treatment.…”

Section: Discussionmentioning

confidence: 99%

Recurrent abdominal wall mass in a hepatitis B‐positive male: An unusual case of lumbar mycetoma

Abdallah,

Abdelkhalig,

Hamid

et al. 2023

Clinical Case Reports

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Key Clinical MessageAtypical presentations of eumycetoma can pose a challenge in the diagnosis and treatment of the disease. Healthcare providers thorough in their differential diagnosis and investigations, even in the absence of classic symptoms, in order to improve early detection and the case management for such a neglected tropical disease.AbstractIn this communication, we present a case study of an unusual presentation of eumycetoma; a fungal infection that is considered a neglected tropical disease. The patient, a 28‐year‐old male from Sudan, presented with a recurrent mass in the abdominal wall. Despite two surgeries to remove the mass, it continued to recur. Unlike typical cases of eumycetoma, this patient did not exhibit common symptoms such as painless swelling, sinuses, or grain‐containing discharge. The diagnosis was made incidentally after surgical excision of the mass. The abstract highlights the importance of recognizing uncommon presentations and maintaining a high suspicion for rare diagnoses, even in the absence of classic symptoms. Further research is needed to better understand atypical presentations of eumycetoma and improve early detection.

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Section: Discussionmentioning

confidence: 99%

Recurrent abdominal wall mass in a hepatitis B‐positive male: An unusual case of lumbar mycetoma

Abdallah,

Abdelkhalig,

Hamid

et al. 2023

Clinical Case Reports

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“…In long-term ITZ therapy, hepatic dysfunction in patients has been reported to be fatal, so the liver functions of patients should be closely monitored Acosta, 1997a, 1997b;Rodriquez et al, 1999). The liver is the main organ of detoxification of ITZ to remove the toxic metabolites (Lou et al, 2011). However, the mechanism of liver damage in patients undergoing ITZ therapy remains obscure, which could be due to metabolic idiosyncrasy Acosta, 1996, 1997;Rodriquez et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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In the current study, the protective effect of a mistletoe extract (Helixor®, HLX) on Itraconazole (ITZ)induced hepatocellular injury and acute oxidative stress in rats was aimed to be investigated by histological, biochemical and comet assay methods. Four groups a control group, an HLX group (5mg/kg/14days/intraperitoneally (ip)), an ITZ group (100mg/kg/14days/oral) and an HLX plus ITZ group (5mg/kg/14days/ip+100mg/kg/14days/oral) were all created from 32 female Wistar albino rats. At the end of the experiment, AST and ALT liver enzymes, total oxidant status (TOS) levels and total antioxidant status (TAS) levels, histopathological analysis and comet assay were carried out. Highest genotoxicity, higher levels of plasma AST and ALT, higher TOS, more degeneration of liver histopathology including hepatocyte degeneration, hepatocyte apoptosis and necrosis, portal/periportal inflammation, bile ductus hyperplasia and multinuclear giant cell formation were observed in ITZ group (p<0.05). As opposed to that, administration of HLX plus ITZ improved histopathological changes and DNA damage and showed a dramatic decrease in AST, ALT and TOS levels (p<0.05) and an increase in TAS level (p<0.001) when compared to ITZ group. This study showed that the antioxidant properties of HLX administration significantly decreased acute oxidative stress and hepatocellular damage in rats given ITZ.

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