Hepatic enzymes have a role in the diagnosis of hepatic injury after blunt abdominal trauma

Role of elevated liver transaminase enzymes in diagnosis of liver injury in cases after abdominal trauma

“…This is agreement with Tan KK et al, who documented that sensitivity of lactate dehydrogenase in diagnosis of liver trauma is 95.7% with specificity 25%, The presence of LDH in many body tissues other than the liver makes the low specificity of LDH in detection of liver injury. 14 In our study serum bilrubin, alkaline phosphatase enzymes and serum albumen were usually normal in both liver injury and non-liver injury group and there were not related to any liver trauma, with low sensitivity and specificity in diagnosis of liver trauma. This is agreement with Tan KK et al, who studied the role of hepatic enzymes in the diagnosis of hepatic injury, who documented that both ALP and bilirubin were not useful in the screening of hepatic injuries.…”

“…14 This relation was also seen in patients with raised AST > 2 times. This difference was not seen in both bilirubin and ALP.…”

Evaluation of liver injury in a tertiary hospital: a retrospective study

“…Several studies have identified hemodynamic instability as an early predictor of outcome after severe injuries. [4,9,14,[18][19][20][21] It has been shown by Clarke et al [22] that mortality increases by 1% every 3 minutes after a trauma involving hematogenic shock. Also, Wilson have emphasized that shock on admission is thought to double the mortality rates.…”

“…[35] Similarly, statistically significant and increasing ALT levels were observed among patients with increasing grades of liver injury. [7] Tan et al [21] have reported that there is an important relationship between ALT, AST and hepatic injuries after blunt abdominal trauma and also patients with normal ALT, AST and LDH are unlikely to have major liver injury. Nishida et al [18] have shown that ALT is an independent risk factor for mortality in their multivariate analysis.…”

Enzyme-Based Logic Analysis of Biomarkers at Physiological Concentrations: AND Gate with Double-Sigmoid “Filter” Response

“…These were selected to correspond to meaningful circulating levels of these biomarkers under normal physiological and pathophysiological conditions, respectively. [43][44][45] For mapping out the gate-function properties, varying …”