Hepatic encephalopathy complications are diminished by piracetam via the interaction between mitochondrial function, oxidative stress, inflammatory response, and locomotor activity

Niknahad, Hossein; Mobasheri, Ali; Arjmand, Abdollah; Rafiei, Elahe; Alidaee, Sepideh; Razavi, Hadi; Bagheri, Sara; Rezaei, Heresh; Sabouri, Samira; Najibi, Asma; Khodaei, Forouzan; Kashani, Seyyed Mohammad Amin; Ommati, Mohammad Mehdi; Heidari, Reza

doi:10.1016/j.heliyon.2023.e20557

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e20557

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Hepatic encephalopathy complications are diminished by piracetam via the interaction between mitochondrial function, oxidative stress, inflammatory response, and locomotor activity

Hossein Niknahad,

Ali Mobasheri,

Abdollah Arjmand

et al.

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2024

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Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

Zhang,

2024

Hum Exp Toxicol

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Thioacetamide (TAA), a widely employed hepatotoxic substance, has gained significant traction in the induction of liver failure disease models. Upon administration of TAA to experimental animals, the production of potent oxidative derivatives ensues, culminating in the activation of oxidative stress and subsequent infliction of severe damage upon multiple organs via dissemination through the bloodstream. This review summarized the various organ damages and corresponding mechanistic explanations observed in previous studies using TAA in toxicological animal experiments. The principal pathological consequences arising from TAA exposure encompass oxidative stress, inflammation, lipid peroxidation, fibrosis, apoptosis induction, DNA damage, and osteoclast formation. Recent in vivo and in vitro studies on TAA bone toxicity have confirmed that long-term high-dose use of TAA not only induces liver damage in experimental animals but also accompanies bone damage, which was neglected for a long time. By using TAA to model diseases in experimental animals and controlling TAA dosage, duration of use, and animal exposure environment, we can induce various organ injury models. It should be noted that TAA-induced injuries have a time-dependent effect. Finally, in our daily lives, especially for researchers, we should take precautions to minimize TAA exposure and reduce the probability of related organ injuries.

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Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

Zhang,

2024

Hum Exp Toxicol

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Hepatic encephalopathy complications are diminished by piracetam via the interaction between mitochondrial function, oxidative stress, inflammatory response, and locomotor activity

Cited by 1 publication

References 103 publications

Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

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